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RESEARCH ARTICLE (Open Access)

New antibiotics to combat One Health AMR

Abiodun David Ogunniyi https://orcid.org/0000-0001-9308-5629 A , Henrietta Venter https://orcid.org/0000-0001-5569-7755 B and Mark A. T. Blaskovich https://orcid.org/0000-0001-9447-2292 C *
+ Author Affiliations
- Author Affiliations

A Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (CEAStAR) and Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA 5371, Australia. Email: david.ogunniyi@adelaide.edu.au

B Clinical and Health Sciences, University of South Australia, Adelaide, 5000, Australia. Email: rietie.venter@unisa.edu.au

C CEAStAR and The Community for Open Antimicrobial Drug Discovery (CO-ADD), Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia. Email: m.blaskovich@uq.edu.au




Assoc. Prof. David Ogunniyi is a Fellow of the Australian Society for Microbiology and novel antibacterial pre-clinical experimental lead at the Australian Centre for Antimicrobial Resistance Ecology, The University of Adelaide. He currently focuses on developing bioluminescent mouse infection models for testing new antimicrobial drug classes. He has published 2 book chapters, >110 manuscripts and >25 scientific reports for Industry. At CEAStAR, Assoc. Prof Ogunniyi co-ordinates the novel antibacterial pre-clinical experimental strategy, industry engagement and training of HDRs and postdocs in bioluminescent mouse infection models.



Assoc. Prof. Rietie Venter is the Head of Microbiology in Clinical and Health Sciences at the University of South Australia. After obtaining PhD degree at the University of Leeds, Rietie spent 12 years at the University of Cambridge doing research on multidrug transporters, first as a postdoc and later leading her research group as a Dorothy Hodgkin Royal Society Fellow. She joined UniSA in 2012 where she is heading an internationally acclaimed research group on understanding and combating AMR.



Prof. Mark Blaskovich is an ‘antibiotic hunter’ and Director of Translation for the Institute for Molecular Bioscience at The University of Queensland, as well as Director of the ARC Industrial Transformation Training Centre, CEAStAR, and the antibiotic crowdsourcing initiative CO-ADD. A medicinal chemist with 15 years of industrial drug development experience, since 2010 he has been developing new antibiotics, non-antibiotic therapies and diagnostics to detect and treat resistant bacterial and fungal infections, including multiple industry collaborations focused on AMR.

* Correspondence to: m.blaskovich@uq.edu.au

Microbiology Australia https://doi.org/10.1071/MA24022
Submitted: 28 March 2024  Accepted: 2 May 2024  Published: 23 May 2024

© 2024 The Author(s) (or their employer(s)). Published by CSIRO Publishing on behalf of the ASM. This is an open access article distributed under the Creative Commons Attribution 4.0 International License (CC BY).

Abstract

The rise of antimicrobial resistance has been accompanied by a decline in the development of new antibiotics. In this article, we explore the current state of affairs and trends in both human- and animal-related antibiotic development activity, with distinct differences between the two sectors.

Keywords: AMR, antimicrobial drug development, antimicrobial pipeline, antimicrobial resistance, One Health.

Biographies

MA24022_B1.gif

Assoc. Prof. David Ogunniyi is a Fellow of the Australian Society for Microbiology and novel antibacterial pre-clinical experimental lead at the Australian Centre for Antimicrobial Resistance Ecology, The University of Adelaide. He currently focuses on developing bioluminescent mouse infection models for testing new antimicrobial drug classes. He has published 2 book chapters, >110 manuscripts and >25 scientific reports for Industry. At CEAStAR, Assoc. Prof Ogunniyi co-ordinates the novel antibacterial pre-clinical experimental strategy, industry engagement and training of HDRs and postdocs in bioluminescent mouse infection models.

MA24022_B2.gif

Assoc. Prof. Rietie Venter is the Head of Microbiology in Clinical and Health Sciences at the University of South Australia. After obtaining PhD degree at the University of Leeds, Rietie spent 12 years at the University of Cambridge doing research on multidrug transporters, first as a postdoc and later leading her research group as a Dorothy Hodgkin Royal Society Fellow. She joined UniSA in 2012 where she is heading an internationally acclaimed research group on understanding and combating AMR.

MA24022_B3.gif

Prof. Mark Blaskovich is an ‘antibiotic hunter’ and Director of Translation for the Institute for Molecular Bioscience at The University of Queensland, as well as Director of the ARC Industrial Transformation Training Centre, CEAStAR, and the antibiotic crowdsourcing initiative CO-ADD. A medicinal chemist with 15 years of industrial drug development experience, since 2010 he has been developing new antibiotics, non-antibiotic therapies and diagnostics to detect and treat resistant bacterial and fungal infections, including multiple industry collaborations focused on AMR.

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