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RESEARCH ARTICLE

Public health impact of the Enteroviruses and Parechoviruses

Ben Knippenberg A and Mark J Ferson B
+ Author Affiliations
- Author Affiliations

A Public Health, South Eastern Sydney Local Health District Randwick, NSW, Australia Email: ben.knippenberg@health.nsw.gov.au

B School of Public Health and Community Medicine University of New South Wales Kensington, NSW, Australia

Microbiology Australia 38(4) 198-200 https://doi.org/10.1071/MA17069
Published: 9 November 2017

Abstract

Enteroviruses (EV) comprise viruses originally classified on cell culture replication patterns and clinical manifestations into a number of groups: poliovirus, coxsackievirus A, coxsackievirus B and ECHOvirus. The closely related genus Parechovirus has more recently been associated with human disease. EVs are common commensals of the human gut, often found without any ill effects on the person, but are also associated with a wide range of diseases and syndromes including non-specific rash illnesses, hand, foot and mouth disease (HFMD), conjunctivitis, meningitis and encephalitis, myocarditis and polio. This results in a significant burden of disease worldwide, often due to a particular genotype of EV. An estimated 1 billion people are infected with EV every year.


References

[1]  http://polioeradication.org/polio-today/polio-now/this-week/ (accessed 23 September 2017).

[2]  http://www.vidrl.org.au/laboratories/poliovirus-reference/afp-surveillance/ (accessed 23 September 2017).

[3]  Cumming, G. et al. (2015) Parechovirus genotype 3 outbreak among infants, New South Wales, Australia, 2013–2014. Emerg. Infect. Dis. 21, 1144–1152.
Parechovirus genotype 3 outbreak among infants, New South Wales, Australia, 2013–2014.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC28XitVOisbzE&md5=dab967e871c2a928c0e0a9b612686127CAS |

[4]  Ho, M. et al. (1999) An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group. N. Engl. J. Med. 341, 929–935.
An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK1Mvht1Sktg%3D%3D&md5=a56e539b951f6d3c340400a120411a38CAS |

[5]  Zhang, Y. et al. (2010) An emerging recombinant human Enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China. Virol. J. 7, 94.
An emerging recombinant human Enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China.Crossref | GoogleScholarGoogle Scholar |

[6]  Teoh, H.-L. et al. (2016) Clinical characteristics and functional motor outcomes of Enterovirus 71 neurological disease in children. JAMA Neurol. 73, 300–307.
Clinical characteristics and functional motor outcomes of Enterovirus 71 neurological disease in children.Crossref | GoogleScholarGoogle Scholar |

[7]  Peci, A. et al. (2015) Epidemiology of Enterovirus D68 in Ontario. PLoS One 10, e0142841.
Epidemiology of Enterovirus D68 in Ontario.Crossref | GoogleScholarGoogle Scholar |

[8]  Dunn, J.J. (2016) Enteroviruses and Parechoviruses. Microbiol. Spectr. 4, .
| 1:CAS:528:DC%2BC2sXhsVGgtr7L&md5=33093374d04801f0b3bd03e692ca41d8CAS |

[9]  Kung, C.-M. et al. (2007) Differences in replication capacity between enterovirus 71 isolates obtained from patients with encephalitis and those obtained from patients with herpangina in Taiwan. J. Med. Virol. 79, 60–68.
Differences in replication capacity between enterovirus 71 isolates obtained from patients with encephalitis and those obtained from patients with herpangina in Taiwan.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhtFKrug%3D%3D&md5=ff372424c99d51eec5f99179ae3f7277CAS |

[10]  Cheng, H.-Y. et al. (2014) The correlation between the presence of viremia and clinical severity in patients with enterovirus 71 infection: a multi-center cohort study. BMC Infect. Dis. 14, 417.
The correlation between the presence of viremia and clinical severity in patients with enterovirus 71 infection: a multi-center cohort study.Crossref | GoogleScholarGoogle Scholar |

[11]  Papadakis, G. et al. (2014) Detection and genotyping of enteroviruses in cerebrospinal fluid in patients in Victoria, Australia, 2007–2013. J. Med. Virol. 86, 1609–1613.
Detection and genotyping of enteroviruses in cerebrospinal fluid in patients in Victoria, Australia, 2007–2013.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXhtFClur3O&md5=152a38edb1a9e5c53fd926227b92bd5cCAS |

[12]  WHO. (2011) A guide to clinical management and public health response for hand, foot and mouth disease (HFMD). WHO Press, Geneva. Public Health. 18.

[13]  Abzug, M.J. et al. (2016) A randomized, double-blind, placebo-controlled trial of pleconaril for the treatment of neonates with enterovirus sepsis. J. Pediatric Infect. Dis. Soc. 5, 53–62.
A randomized, double-blind, placebo-controlled trial of pleconaril for the treatment of neonates with enterovirus sepsis.Crossref | GoogleScholarGoogle Scholar |

[14]  Zhu, F.-C. et al. (2013) Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet (London, England) 381, 2024–2032.
Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXosVGjt7k%3D&md5=47753abfad0a989085625b1c564367a3CAS |

[15]  Li, R. et al. (2014) An inactivated enterovirus 71 vaccine in healthy children. N. Engl. J. Med. 370, 829–837.
An inactivated enterovirus 71 vaccine in healthy children.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXjs1ygsbo%3D&md5=f7cefabba4e17cae5bcdfba924ef0197CAS |

[16]  Wallace, S.S. et al. (2017) Impact of enterovirus testing on resource use in febrile young infants: a systematic review. Hosp. Pediatr. 7, 96–102.
Impact of enterovirus testing on resource use in febrile young infants: a systematic review.Crossref | GoogleScholarGoogle Scholar |

[17]  Durrheim, D.N. et al. (2012) The adequacy of encephalitis surveillance for emerging infectious diseases in Australia. Retrovirology 9, O9.
The adequacy of encephalitis surveillance for emerging infectious diseases in Australia.Crossref | GoogleScholarGoogle Scholar |