Pharmaceutical pollution in marine waters and benthic flora of the southern Australian coastline
Benjamin M. Long
A * , Samantha Harriage A , Nick L. Schultz A , Craig D. H. Sherman B and Michael Thomas C
+ Author Affiliations
- Author Affiliations
A Future Regions Research Centre, Federation University Australia, Mt Helen, Vic. 3350, Australia.
B School of Life and Environmental Sciences, Deakin University, Waurn Ponds, Vic. 3219, Australia.
C Research and Development, Barwon Water, Geelong, Vic. 3220, Australia.
Environmental Chemistry 19(6) 375-384 https://doi.org/10.1071/EN22054
Submitted: 1 June 2022 Accepted: 14 November 2022 Published: 6 January 2023
© 2022 The Author(s) (or their employer(s)). Published by CSIRO Publishing. This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND)
Environmental context. Most human pharmaceutical waste is discharged to the environment. While the presence of pharmaceuticals in freshwater systems is well documented globally, little is known of the impact on marine ecosystems. We measured pharmaceuticals in a marine environment in south-eastern Australia and found pharmaceutical concentrations around 24 000 times higher in benthic flora than in the marine surface waters. We discuss the potential use of seaweeds as biological indicators of pharmaceutical pollution.
Rationale. Pharmaceuticals are emerging pollutants of concern with a range of adverse consequences for organisms and ecosystems. Their presence in freshwater and estuarine systems has been well documented, but less is known about their prevalence in open ocean, or their uptake by benthic flora. This preliminary survey of the southern Australian coastline sought to measure the concentrations of key pharmaceuticals in both surface waters and benthic flora.
Methodology. This study used LC-MS/MS to measure the concentration carbamazepine, tramadol and venlafaxine in (1) samples from wastewater treatment plants, (2) ocean surface waters and (3) several species of benthic flora. Surface waters and benthic flora were sampled at two sites near waste water treatment plant (WWTP) discharges, and one site away from any discharge.
Results. All three pharmaceuticals were detected in surface water samples with their risk assessed (via risk quotient) as medium risk (carbamazepine) or low risk (venlafaxine, tramadol). All three pharmaceuticals were also detected in benthic flora, particularly in brown macroalgae; Tramadol was measured at a maximum of 34.7 ng g−1 in Hormosira banksii, and Venlafaxine was recorded at a maximum of 17.3 ng g−1 in Caulocystis cephalornithos.
Discussion. The calculated bioconcentration factors suggest the pharmaceutical concentrations in benthic flora were up to ~24 000 times higher than in surrounding surface water. There was also evidence that proximity to WWTP outfalls influenced the levels of pharmaceuticals in benthic flora. The results suggest that the benthic flora may be suitable bioindicators of pharmaceutical contamination and that the potential impacts of pharmaceutical pollutants in marine ecosystems demand further investigation.
Keywords: benthic flora, bioindicators, emerging contaminant, macroalgae, marine, pharmaceutical pollution, risk assessment, risk quotient.
References
Adeleye AS, Xue J, Zhao Y, Taylor AA, Zenobio JE, Sun Y, Han Z, Salawu OA, Zhu Y (2022). Abundance, fate, and effects of pharmaceuticals and personal care products in aquatic environments. Journal of Hazardous Materials 424, 127284| Abundance, fate, and effects of pharmaceuticals and personal care products in aquatic environments.Crossref | GoogleScholarGoogle Scholar |
Afsa S, Hamden K, Lara Martin PA, Mansour HB (2020). Occurrence of 40 pharmaceutically active compounds in hospital and urban wastewaters and their contribution to Mahdia coastal seawater contamination. Environmental Science and Pollution Research 27, 1941–1955.
| Occurrence of 40 pharmaceutically active compounds in hospital and urban wastewaters and their contribution to Mahdia coastal seawater contamination.Crossref | GoogleScholarGoogle Scholar |
Ali AM, Rønning HT, Sydnes LK, Alarif WM, Kallenborn R, Al-Lihaibi SS (2018). Detection of PPCPs in marine organisms from contaminated coastal waters of the Saudi Red Sea. Science of The Total Environment 621, 654–662.
| Detection of PPCPs in marine organisms from contaminated coastal waters of the Saudi Red Sea.Crossref | GoogleScholarGoogle Scholar |
Álvarez-Muñoz D, Rodríguez-Mozaz S, Maulvault AL, Tediosi A, Fernández-Tejedor M, Van den Heuvel F, Kotterman M, Marques A, Barceló D (2015). Occurrence of pharmaceuticals and endocrine disrupting compounds in macroalgaes, bivalves, and fish from coastal areas in Europe. Environmental Research 143, 56–64.
| Occurrence of pharmaceuticals and endocrine disrupting compounds in macroalgaes, bivalves, and fish from coastal areas in Europe.Crossref | GoogleScholarGoogle Scholar |
Alygizakis NA, Gago-Ferrero P, Borova VL, Pavlidou A, Hatzianestis I, Thomaidis NS (2016). Occurrence and spatial distribution of 158 pharmaceuticals, drugs of abuse and related metabolites in offshore seawater. Science of The Total Environment 541, 1097–1105.
| Occurrence and spatial distribution of 158 pharmaceuticals, drugs of abuse and related metabolites in offshore seawater.Crossref | GoogleScholarGoogle Scholar |
Anim AK, Thompson K, Duodu GO, Tscharke B, Birch G, Goonetilleke A, Ayoko GA, Mueller JF (2020). Pharmaceuticals, personal care products, food additive and pesticides in surface waters from three Australian east coast estuaries (Sydney, Yarra and Brisbane). Marine Pollution Bulletin 153, 111014
| Pharmaceuticals, personal care products, food additive and pesticides in surface waters from three Australian east coast estuaries (Sydney, Yarra and Brisbane).Crossref | GoogleScholarGoogle Scholar |
Arnot JA, Gobas FAPC (2006). A review of bioconcentration factor (BCF) and bioaccumulation factor (BAF) assessments for organic chemicals in aquatic organisms. Environmental Reviews 14, 257–297.
| A review of bioconcentration factor (BCF) and bioaccumulation factor (BAF) assessments for organic chemicals in aquatic organisms.Crossref | GoogleScholarGoogle Scholar |
Australian Bureau of Statistics (2016) 2016 Census QuickStats. Retrieved from Australian Bureau of Statistics. Available at https://www.abs.gov.au/census/find‐census‐data/quickstats/2016/CED801
Australian Bureau of Statistics (2021) Australian Statistical Geography Standard (ASGS) Edition 3. Available at https://www.abs.gov.au/statistics/standards/australian-statistical-geography-standard-asgs-edition-3/jul2021-jun2026 [verified 18 August 2022]
Ben W, Zhu B, Yuan X, Zhang Y, Yang M, Qiang Z (2018). Occurrence, removal and risk of organic micropollutants in wastewater treatment plants across China: Comparison of wastewater treatment processes. Water Research 130, 38–46.
| Occurrence, removal and risk of organic micropollutants in wastewater treatment plants across China: Comparison of wastewater treatment processes.Crossref | GoogleScholarGoogle Scholar |
Biel-Maeso M, Baena-Nogueras RM, Corada-Fernández C, Lara-Martín PA (2018). Occurrence, distribution and environmental risk of pharmaceutically active compounds (PhACs) in coastal and ocean waters from the Gulf of Cadiz (SW Spain). Science of the Total Environment 612, 649–659.
| Occurrence, distribution and environmental risk of pharmaceutically active compounds (PhACs) in coastal and ocean waters from the Gulf of Cadiz (SW Spain).Crossref | GoogleScholarGoogle Scholar |
Birch GF, Drage DS, Thompson K, Eaglesham G, Mueller JF (2015). Emerging contaminants (pharmaceuticals, personal care products, a food additive and pesticides) in waters of Sydney estuary, Australia. Marine Pollution Bulletin 97, 56–66.
| Emerging contaminants (pharmaceuticals, personal care products, a food additive and pesticides) in waters of Sydney estuary, Australia.Crossref | GoogleScholarGoogle Scholar |
Botero-Coy AM, Martínez-Pachón D, Boix C, Rincón RJ, Castillo N, Arias-Marín LP, Manrique-Losada L, Torres-Palma R, Moncayo-Lasso A, Hernández F (2018). ‘An investigation into the occurrence and removal of pharmaceuticals in Colombian wastewater’. Science of the Total Environment 642, 842–853.
| ‘An investigation into the occurrence and removal of pharmaceuticals in Colombian wastewater’.Crossref | GoogleScholarGoogle Scholar |
Branchet P, Arpin-Pont L, Piram A, Boissery P, Wong-Wah-Chung P, Doumenq P (2021). Pharmaceuticals in the marine environment: What are the present challenges in their monitoring. Science of the Total Environment 766, 142644
| Pharmaceuticals in the marine environment: What are the present challenges in their monitoring.Crossref | GoogleScholarGoogle Scholar |
Doblin MA, Clayton MN (1995). Effects of secondarily-treated sewage effluent on the early life-history stages of two species of brown macroalgae: Hormosira banksii and Durvillaea potatorum. Marine Biology 122, 689–698.
| Effects of secondarily-treated sewage effluent on the early life-history stages of two species of brown macroalgae: Hormosira banksii and Durvillaea potatorum.Crossref | GoogleScholarGoogle Scholar |
Du B, Perez‐Hurtado P, Brooks BW, Chambliss CK (2012). Evaluation of an isotope dilution liquid chromatography tandem mass spectrometry method for pharmaceuticals in fish. Journal of Chromatography A 1253, 177–183.
| Evaluation of an isotope dilution liquid chromatography tandem mass spectrometry method for pharmaceuticals in fish.Crossref | GoogleScholarGoogle Scholar |
Duarte IA, Fick J, Cabral HN, Fonseca VF (2022). Bioconcentration of neuroactive pharmaceuticals in fish: Relation to lipophilicity, experimental design and toxicity in the aquatic environment. Science of the Total Environment 812, 152543
| Bioconcentration of neuroactive pharmaceuticals in fish: Relation to lipophilicity, experimental design and toxicity in the aquatic environment.Crossref | GoogleScholarGoogle Scholar |
European Commission (2006) Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the registration, evaluation, authorisation and restriction of chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. Official Journal of the European Union 396, 1–849.
Fabbri E, Franzellitti S (2016). Human pharmaceuticals in the marine environment: Focus on exposure and biological effects in animal species. Environmental Toxicology and Chemistry 35, 799–812.
| Human pharmaceuticals in the marine environment: Focus on exposure and biological effects in animal species.Crossref | GoogleScholarGoogle Scholar |
Feito R, Valcárcel Y, Catalá M (2013). Preliminary data suggest that venlafaxine environmental concentrations could be toxic to plants. Chemosphere 90, 2065–2069.
| Preliminary data suggest that venlafaxine environmental concentrations could be toxic to plants.Crossref | GoogleScholarGoogle Scholar |
Fernández-Rubio J, Rodríguez-Gil JL, Postigo C, Mastroianni N, López de Alda M, Barceló D, Valcárcel Y (2019). Psychoactive pharmaceuticals and illicit drugs in coastal waters of North-Western Spain: Environmental exposure and risk assessment. Chemosphere 224, 379–389.
| Psychoactive pharmaceuticals and illicit drugs in coastal waters of North-Western Spain: Environmental exposure and risk assessment.Crossref | GoogleScholarGoogle Scholar |
Freitas R, Almeida Â, Calisto V, Velez C, Moreira A, Schneider RJ, Esteves VI, Wrona FJ, Figueira E, Soares AMVM (2016). The impacts of pharmaceutical drugs under ocean acidification: New data on single and combined long-term effects of carbamazepine on Scrobicularia plana. Science of the Total Environment 541, 977–985.
| The impacts of pharmaceutical drugs under ocean acidification: New data on single and combined long-term effects of carbamazepine on Scrobicularia plana.Crossref | GoogleScholarGoogle Scholar |
French VA, Codi King S, Kumar A, Northcott G, McGuinness K, Parry D (2015). Characterisation of microcontaminants in Darwin Harbour, a tropical estuary of northern Australia undergoing rapid development. Science of the Total Environment 536, 639–647.
| Characterisation of microcontaminants in Darwin Harbour, a tropical estuary of northern Australia undergoing rapid development.Crossref | GoogleScholarGoogle Scholar |
Gani KM, Hlongwa N, Abunama T, Kumari S, Bux F (2021). Emerging contaminants in South African water environment- a critical review of their occurrence, sources and ecotoxicological risks. Chemosphere 269, 128737
| Emerging contaminants in South African water environment- a critical review of their occurrence, sources and ecotoxicological risks.Crossref | GoogleScholarGoogle Scholar |
Halling-Sørensen B, Nors Nielsen S, Lanzky PF, Ingerslev F, Holten Lützhøft HC, Jørgensen SE (1998). Occurrence, fate and effects of pharmaceutical substances in the environment- A review. Chemosphere 36, 357–393.
| Occurrence, fate and effects of pharmaceutical substances in the environment- A review.Crossref | GoogleScholarGoogle Scholar |
Hignite C, Azarnoff DL (1977). Drugs and drug metabolites as environmental contaminants: Chlorophenoxyisobutyrate and salicylic acid in sewage water effluent. Life Sciences 20, 337–341.
| Drugs and drug metabolites as environmental contaminants: Chlorophenoxyisobutyrate and salicylic acid in sewage water effluent.Crossref | GoogleScholarGoogle Scholar |
Jarvis AL, Bernot MJ, Bernot RJ (2014). The effects of the psychiatric drug carbamazepine on freshwater invertebrate communities and ecosystem dynamics. Science of the Total Environment 496, 461–470.
| The effects of the psychiatric drug carbamazepine on freshwater invertebrate communities and ecosystem dynamics.Crossref | GoogleScholarGoogle Scholar |
Jelic A, Gros M, Ginebreda A, Cespedes-Sánchez R, Ventura F, Petrovic M, Barcelo D (2011). Occurrence, partition and removal of pharmaceuticals in sewage water and sludge during wastewater treatment. Water Research 45, 1165–1176.
| Occurrence, partition and removal of pharmaceuticals in sewage water and sludge during wastewater treatment.Crossref | GoogleScholarGoogle Scholar |
Katsikaros AG, Chrysikopoulos CV (2021). Occurrence and distribution of pharmaceuticals and personal care products (PPCPs) detected in lakes around the world - A review. Environmental Advances 6, 100131
| Occurrence and distribution of pharmaceuticals and personal care products (PPCPs) detected in lakes around the world - A review.Crossref | GoogleScholarGoogle Scholar |
Khan HK, Rehman MYA, Junaid M, Lv M, Yue L, Haq I-u, Xu N, Malik RN (2021). Occurrence, source apportionment and potential risks of selected PPCPs in groundwater used as a source of drinking water from key urban-rural settings of Pakistan. Science of the Total Environment 807, 151010
| Occurrence, source apportionment and potential risks of selected PPCPs in groundwater used as a source of drinking water from key urban-rural settings of Pakistan.Crossref | GoogleScholarGoogle Scholar |
Lamichhane K, Garcia SN, Huggett DB, DeAngelis DL, La Point TW (2013). Chronic Effects of Carbamazepine on Life-History Strategies of Ceriodaphnia dubia in Three Successive Generations. Archives of Environmental Contamination and Toxicology 64, 427–438.
| Chronic Effects of Carbamazepine on Life-History Strategies of Ceriodaphnia dubia in Three Successive Generations.Crossref | GoogleScholarGoogle Scholar |
Madikizela LM, Ncube S, Tutu H, Richards H, Newman B, Ndungu K, Chimuka L (2020). Pharmaceuticals and their metabolites in the marine environment: Sources, analytical methods and occurrence. Trends in Environmental Analytical Chemistry 28, e00104
| Pharmaceuticals and their metabolites in the marine environment: Sources, analytical methods and occurrence.Crossref | GoogleScholarGoogle Scholar |
Maranho LA, DelValls TA, Martín-Díaz ML (2015). Assessing potential risks of wastewater discharges to benthic biota: An integrated approach to biomarker responses in clams (Ruditapes philippinarum) exposed under controlled conditions. Marine Pollution Bulletin 92, 11–24.
| Assessing potential risks of wastewater discharges to benthic biota: An integrated approach to biomarker responses in clams (Ruditapes philippinarum) exposed under controlled conditions.Crossref | GoogleScholarGoogle Scholar |
Martínez Bueno MJ, Herrera S, Munaron D, Boillot C, Fenet H, Chiron S, Gómez E (2016). POCIS passive samplers as a monitoring tool for pharmaceutical residues and their transformation products in marine environment. Environmental Science and Pollution Research 23, 5019–5029.
| POCIS passive samplers as a monitoring tool for pharmaceutical residues and their transformation products in marine environment.Crossref | GoogleScholarGoogle Scholar |
Meyer MF, Powers SM, Hampton SE (2019). An Evidence Synthesis of Pharmaceuticals and Personal Care Products (PPCPs) in the Environment: Imbalances among Compounds, Sewage Treatment Techniques, and Ecosystem Types. Environmental Science & Technology 53, 12961–12973.
| An Evidence Synthesis of Pharmaceuticals and Personal Care Products (PPCPs) in the Environment: Imbalances among Compounds, Sewage Treatment Techniques, and Ecosystem Types.Crossref | GoogleScholarGoogle Scholar |
Mostofa KMG, Liu C-Q, Vione D, Gao K, Ogawa H (2013). Sources, factors, mechanisms and possible solutions to pollutants in marine ecosystems. Environmental Pollution 182, 461–478.
| Sources, factors, mechanisms and possible solutions to pollutants in marine ecosystems.Crossref | GoogleScholarGoogle Scholar |
Ogle DH, Wheeler P, Dinno A (2021) FSA: Fisheries Stock Analysis. R package version 0.8.32. Available at https://github.com/droglenc/FSA
Painter MM, Buerkley MA, Julius ML, Vajda AM, Norris DO, Barber LB, Furlong ET, Schultz MM, Schoenfuss HL (2009). Antidepressants at environmentally relevant concentrations affect predator avoidance behavior of larval fathead minnows (Pimephales promelas). Environmental Toxicology and Chemistry 28, 2677–2684.
| Antidepressants at environmentally relevant concentrations affect predator avoidance behavior of larval fathead minnows (Pimephales promelas).Crossref | GoogleScholarGoogle Scholar |
Quinn B, Gagné F, Blaise C (2008). An investigation into the acute and chronic toxicity of eleven pharmaceuticals (and their solvents) found in wastewater effluent on the cnidarian, Hydra attenuata. Science of the Total Environment 389, 306–314.
| An investigation into the acute and chronic toxicity of eleven pharmaceuticals (and their solvents) found in wastewater effluent on the cnidarian, Hydra attenuata.Crossref | GoogleScholarGoogle Scholar |
R Core Team (2021) ‘R: A language and environment for statistical computing.’ (R Foundation for Statistical Computing: Vienna, Austria)
Richmond EK, Rosi EJ, Walters DM, Fick J, Hamilton SK, Brodin T, Sundelin A, Grace MR (2018). A diverse suite of pharmaceuticals contaminates stream and riparian food webs. Nature Communications 9, 4491
| A diverse suite of pharmaceuticals contaminates stream and riparian food webs.Crossref | GoogleScholarGoogle Scholar |
Roberts J, Kumar A, Du J, Hepplewhite C, Ellis DJ, Christy AG, Beavis SG (2016). Pharmaceuticals and personal care products (PPCPs) in Australia’s largest inland sewage treatment plant, and its contribution to a major Australian river during high and low flow. Science of The Total Environment 541, 1625–1637.
| Pharmaceuticals and personal care products (PPCPs) in Australia’s largest inland sewage treatment plant, and its contribution to a major Australian river during high and low flow.Crossref | GoogleScholarGoogle Scholar |
Rohmana QA, Fischer A, Gemmill J (2021) National Outfall Database: Outfall Ranking Report 2019/2020 Financial Year. Report to the Department of Agriculture, Water and Environment. Australia: Clean Ocean Foundation and University of Tasmania.
Santos MES, Horký P, Grabicová K, Hubená P, Slavík O, Grabic R, Douda K, Randák T (2021). Traces of tramadol in water impact behaviour in a native European fish. Ecotoxicology and Environmental Safety 212, 111999
| Traces of tramadol in water impact behaviour in a native European fish.Crossref | GoogleScholarGoogle Scholar |
Schiel DR, Taylor DI (1999). Effects of trampling on a rocky intertidal algal assemblage in southern New Zealand. Journal of Experimental Marine Biology and Ecology 235, 213–235.
| Effects of trampling on a rocky intertidal algal assemblage in southern New Zealand.Crossref | GoogleScholarGoogle Scholar |
Scott PD, Bartkow M, Blockwell SJ, Coleman HM, Khan SJ, Lim R, McDonald JA, Nice H, Nugegoda D, Pettigrove V, Tremblay LA, Warne MSJ, Leusch FDL (2014). A national survey of trace organic contaminants in Australian rivers. Journal of Environmental Quality 43, 1702–1712.
| A national survey of trace organic contaminants in Australian rivers.Crossref | GoogleScholarGoogle Scholar |
South Australian Environmental Protection Agency (2019) Pharmaceutical products and other human-sourced chemicals in creeks. Available at https://www.epa.sa.gov.au/files/14363_info_wq_pharma_study.pdf [verified 1 December 2020]
Srain HS, Beazley KF, Walker TR (2021). Pharmaceuticals and personal care products and their sublethal and lethal effects in aquatic organisms. Environmental Reviews 29, 142–181.
| Pharmaceuticals and personal care products and their sublethal and lethal effects in aquatic organisms.Crossref | GoogleScholarGoogle Scholar |
Świacka K, Maculewicz J, Smolarz K, Szaniawska A, Caban M (2019). Mytilidae as model organisms in the marine ecotoxicology of pharmaceuticals - A review. Environmental Pollution 254, 113082
| Mytilidae as model organisms in the marine ecotoxicology of pharmaceuticals - A review.Crossref | GoogleScholarGoogle Scholar |
Wahlberg C, Björlenius B, Paxéus N (2011). Fluxes of 13 selected pharmaceuticals in the water cycle of Stockholm, Sweden. Water Science and Technology 63, 1772–1780.
| Fluxes of 13 selected pharmaceuticals in the water cycle of Stockholm, Sweden.Crossref | GoogleScholarGoogle Scholar |
Wickham H, François R, Henry L, Müller K (2020) dplyr: A Grammar of Data Manipulation. R package version 1.0.2. Available at https://CRAN.R‐project.org/package=dplyr
Wilkinson JL, Boxall ABA, Kolpin DW, Leung KMY, Lai RWS, Galbán-Malagón C, Adell AD, Mondon J, Metian M, Marchant RA, Bouzas-Monroy A, Cuni-Sanchez A, Coors A, Carriquiriborde P, Rojo M, Gordon C, Cara M, Moermond M, Luarte T, Petrosyan V, Perikhanyan Y, Mahon CS, McGurk CJ, Hofmann T, Kormoker T, Iniguez V, Guzman-Otazo J, Tavares JL, De Figueiredo FG, Razzolini MTP, Dougnon V, Gbaguidi G, Traoré O, Blais JM, Kimpe LE, Wong M, Wong D, Ntchantcho R, Pizarro J, Ying G-G, Chen C-E, Páez M, Martínez-Lara J, Otamonga J-P, Poté J, Ifo SA, Wilson P, Echeverría-Sáenz S, Udikovic-Kolic N, Milakovic M, Fatta-Kassinos D, Ioannou-Ttofa L, Belušová V, Vymazal J, Cárdenas-Bustamante M, Kassa BA, Garric J, Chaumot A, Gibba P, Kunchulia I, Seidensticker S, Lyberatos G, Halldórsson HP, Melling M, Shashidhar T, Lamba M, Nastiti A, Supriatin A, Pourang N, Abedini A, Abdullah O, Gharbia SS, Pilla F, Chefetz B, Topaz T, Yao KM, Aubakirova B, Beisenova R, Olaka L, Mulu JK, Chatanga P, Ntuli V, Blama NT, Sherif S, Aris AZ, Looi LJ, Niang M, Traore ST, Oldenkamp R, Ogunbanwo O, Ashfaq M, Iqbal M, Abdeen Z, O’Dea A, Morales-Saldaña JM, Custodio M, de la Cruz H, Navarrete I, Carvalho F, Gogra AB, Koroma BM, Cerkvenik-Flajs V, Gombač M, Thwala M, Choi K, Kang H, Ladu JLC, Rico A, Amerasinghe P, Sobek A, Horlitz G, Zenker AK, King AC, Jiang J-J, Kariuki R, Tumbo M, Tezel U, Onay TT, Lejju JB, Vystavna Y, Vergeles Y, Heinzen H, Pérez-Parada A, Sims DB, Figy M, Good D, Teta C (2022). Pharmaceutical pollution of the world’s rivers. Proceedings of the National Academy of Sciences 119, e2113947119
| Pharmaceutical pollution of the world’s rivers.Crossref | GoogleScholarGoogle Scholar |
Womersley HBS (1984) The Marine Benthic Flora of Southern Australia Part I. Available at http://www.flora.sa.gov.au/efsa/Marine_Benthic_Flora_SA/Part_I/Ulva_lactuca.shtml [verified 10 December 2021]
Zhou S, Di Paolo C, Wu X, Shao Y, Seiler T-B, Hollert H (2019). Optimization of screening-level risk assessment and priority selection of emerging pollutants – The case of pharmaceuticals in European surface waters. Environment International 128, 1–10.
| Optimization of screening-level risk assessment and priority selection of emerging pollutants – The case of pharmaceuticals in European surface waters.Crossref | GoogleScholarGoogle Scholar |
