Cellular and molecular mechanisms of antimony transport, toxicity and resistance
Markus J. Tamás
+ Author Affiliations
- Author Affiliations
Department of Chemistry and Molecular Biology, University of Gothenburg, Box 462, S-405 30 Göteborg, Sweden. Email: markus.tamas@cmb.gu.se
Markus J. Tamás studied molecular biology and biochemistry at the Lund University (Sweden) and University of Liège (Belgium) and spent a year as a research scholar at the Public Health Research Institute in New York (USA). Tamás completed his PhD at the University of Leuven (Belgium) in 1999, was awarded an assistant professorship by the Swedish Research Council in 2003, and became professor in eukaryotic microbiology at the University of Gothenburg (Sweden) in 2010. |
Environmental Chemistry 13(6) 955-962 https://doi.org/10.1071/EN16075
Submitted: 31 March 2016 Accepted: 5 July 2016 Published: 22 August 2016
Environmental context. Antimony is a toxic metalloid that is used in a wide range of modern technology applications and in medical treatments. The accelerating needs for antimony in various industrial applications has led to concerns about increased human and environmental exposure. This review provides a brief summary of the biological properties of antimony and its mechanisms of actions in cells.
Abstract. Antimony is a toxic metalloid that is naturally present in low amounts in the environment, but can locally reach high concentrations at mining and processing sites. Today, antimony is used in a wide range of modern technology applications and is also an important constituent of pharmacological drugs. The increasing use of antimony has led to concerns about human and environmental exposure. Yet little is known about the biological properties of antimony and its mechanisms of actions in cells. This review will provide a brief summary of how antimony enters and affects cells, and how cells deal with the presence of this metalloid to acquire resistance.
Additional keywords: Acr3, ABC transporter, aquaglyceroporin, arsenic, glutathione, Leishmania, metalloid, yeast.
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