A recent survey of naturally occurring organohalogen compounds
Gordon W. Gribble
+ Author Affiliations
- Author Affiliations
Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA. Email: ggribble@dartmouth.edu
Gordon W. Gribble is a native of San Francisco, California, and completed his undergraduate education at the University of California at Berkeley in 1963. He earned a Ph.D. in organic chemistry at the University of Oregon in 1967. After a National Cancer Institute Postdoctoral Fellowship at the University of California, Los Angeles, he joined the faculty of Dartmouth College in 1968 where has been Full Professor of Chemistry since 1980. He served as Department Chair during 1988–1991. In 2005, he was named to the inaugural endowed Chair as ‘The Dartmouth Professor of Chemistry’. Dr Gribble has published 360 papers in natural product synthesis, synthetic methodology, heterocyclic chemistry, natural organohalogen compounds and synthetic triterpenoids. |
Environmental Chemistry 12(4) 396-405 https://doi.org/10.1071/EN15002
Submitted: 6 January 2015 Accepted: 17 February 2015 Published: 29 May 2015
Environmental context. The general perception that nature does not produce compounds containing halogens – chlorine, bromine, iodine and fluorine – is now known to be erroneous. Modern isolation and identification techniques have led to the discovery of more than 5000 halogen-containing compounds from myriad marine and terrestrial plant and animal sources. Many of these compounds possess extraordinary biological activity, including anticancer, antiviral and antibacterial activity of potential human benefit.
Abstract. This short review presents the naturally occurring organohalogen compounds discovered and characterised in 2014. They include compounds from both marine and terrestrial organisms, such as algae, sponges, corals, tunicates, bryozoans, fungi, bacteria, cyanobacteria and plants. Several novel structural types have been characterised. From only ~24 in 1968, naturally occurring organohalogens currently number more than 5000, and they continue to be discovered in all regions of the world. This review presents the 114 discovered organohalogens from natural sources in the year 2014.
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