The transition from quantitative trait loci to diagnostic test in cattle and other livestock
W. BarendseCSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, Qld 4067, Australia. Email: Bill.Barendse@csiro.au
Australian Journal of Experimental Agriculture 45(8) 831-836 https://doi.org/10.1071/EA05067
Submitted: 1 March 2005 Accepted: 3 June 2005 Published: 26 August 2005
Abstract
The efficient identification of the genes that influence quantitative traits requires: large sample sizes; the analysis of large numbers of polymorphisms in and around genes or surrogates for these; repeated testing in independent samples; the realisation that the inheritance patterns of quantitative trait loci will show the full range of effects found for genes that affect discrete traits; and choosing the appropriate genetic structure of the sample and the kind of DNA polymorphism for the different stages in the identification of the quantitative trait loci. The choice of trait is critical to the successful production of diagnostic tests. Since this is the most important single factor affecting whether a test will be commercialised, not only due to the economic importance of the trait, but whether there are easy, alternative methods to improve the trait that are cheaper to implement than a DNA test.
Additional keywords: QTL, sheep, pigs, DNA, genomics.
Acknowledgments
R. Hawken and I. Purvis provided useful comments and discussion that improved the manuscript. The anonymous reviewers provided some examples that I had inadvertently overlooked, and thereby improved the text.
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