Bovine mammary epithelial cells, initiators of innate immune responses to mastitis
C. Gray A B C , Y. Strandberg A B , L. Donaldson A B and R. L. Tellam A B CA CSIRO Livestock Industries, Queensland Biosciences Precinct, 306 Carmody Road, St Lucia, Qld 4067, Australia.
B Co-operative Research Centre for Innovative Dairy Products, Level 1, 84 William Street, Melbourne, Vic. 3000, Australia.
C Corresponding author. Email: Ross.Tellam@csiro.au
Australian Journal of Experimental Agriculture 45(8) 757-761 https://doi.org/10.1071/EA05046
Submitted: 14 February 2005 Accepted: 27 April 2005 Published: 26 August 2005
Abstract
Innate immunity plays a vital role in the protection of the bovine mammary gland against mastitis. Until recently, the migration of effector cells such as neutrophils and monocytes into the mammary gland was thought to provide the only defence against invading pathogens. However, mammary epithelial cells may also play an important role in the immune response, contributing to the innate defence of the mammary tissue through secretion of antimicrobial peptides and attraction of circulating immune effector cells. This paper reviews the innate immune pathways in mammary epithelial cells and examines their role in the initiation of an innate immune response to Gram-positive and Gram-negative bacteria.
Additional keywords: epithelia, lipopolysaccharide, lipoteichoic acid.
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