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RESEARCH ARTICLE
Contents Vol 45(8)

Harnessing the bovine genome sequence for the Australian cattle and sheep industries

B. P. Dalrymple
+ Author Affiliations
- Author Affiliations

CSIRO Livestock Industries, Queensland Biosciences Precinct, 306 Carmody Road, St Lucia, Qld 4067, Australia. Email: Brian.Dalrymple@csiro.au

Australian Journal of Experimental Agriculture 45(8) 1011-1016 https://doi.org/10.1071/EA05043
Submitted: 9 February 2005  Accepted: 2 June 2005   Published: 26 August 2005

Abstract

Genomics is an emerging science and the release of the human and mouse genomes has significantly altered our picture of the information content of mammalian genomes. A smaller number of protein coding genes, and a larger number of genes that do not appear to encode protein products, the so-called non-coding RNAs (ncRNAs), have been identified. The first 2 drafts of the bovine genome sequence have been released, and work to utilise the framework of the bovine genome to facilitate ovine genomics is underway. In anticipation of the requirement for a detailed analysis of the ruminant genomes, their transcriptomes, interactomes, regulomes and similar, we have been developing the informatics platform for the analysis and integration of genome sequences and expression data for cattle and sheep. This resource will enable us to utilise the ruminant datasets and integrate them with equivalent data from other mammals for the advancement of animal scientific research for applications in the cattle and sheep industries in Australia.


Acknowledgments

The members of the CSIRO Livestock Industries Bioinformatics group; Toni Reverter-Gomez, Wes Barris and Sean McWilliam, without whom this would not have been possible. Rachel Hawken, the power behind IBISS. Ross Tellam for driving the involvement of CSIRO Livestock Industries in the International Bovine BAC Mapping Consortium and the Bovine Genome Project. Shaun Coffey and Peter Willadsen for their support throughout the project.


The partners in the Bovine Genome Sequencing Project are: the National Human Genome Research Institute (USA); CSIRO (Australia); the US Department of Agriculture; the State of Texas; Genome Canada; New Zealand’s Agritech Investments Ltd, Dairy Insight Inc. and AgResearch Ltd; the Kleberg Foundation (USA); and the National, Texas and South Dakota Beef Check-off Funds (USA). The sequencing and assembly of the bovine genome began in December 2003 and is being undertaken at the Baylor College of Medicine’s Human Genome Sequencing Center (USA) and the British Columbia Cancer Agency (Vancouver, Canada).


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