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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

The Preparation of Analogs of the Ether-Linked Dimer and Oligomer Components of Hematoporphyrin Derivative

CJ Byrne and AD Ward

Australian Journal of Chemistry 44(3) 411 - 426
Published: 1991

Abstract

The preparation of ether-linked porphyrin dimers and oligomers which are analogues of those present in the anticancer drugs hematoporphyrin derivative and Photofrin IIR is described. These materials are prepared from the appropriately substituted porphyrins containing a 1-hydroxyethyl or a vinyl side chain through an intermediate 1-bromoethyl derivative. Ether-linked porphyrin dimers with ethyl, formyl , hydroxymethyl and 1-alkoxyethyl side chains were prepared, together with trimers and tetramers containing ethyl side chains. Some of the spectroscopic and biological properties of these compounds are discussed.

https://doi.org/10.1071/CH9910411

© CSIRO 1991

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