The interaction of DNA with aminoacridines and aminobenzacridines

Abstract

The binding curves and thermal denaturation of several DNA- aminoacridine and DNA-amino-benzacridine complexes at two ionic strengths are reported. An increase in viscosity and a decrease in sedimentation velocity were found for these DNA-dye systems.

Free energy calculations based on the intercalation model have been performed. The values so obtained for ΔG are discussed and correlated with the data found in the above experiments.