Register      Login
Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Copper(II) catalysis of the hydrolysis of glycylglycine

IJ Grant and RW Hay

Australian Journal of Chemistry 18(8) 1189 - 1195
Published: 1965

Abstract

Copper(II) ions catalyse the hydrolysis of glycylglycine in the pH range 3.5-6. The pH-rate profile has a maximum at pH 4.2, due to the formation of a complex CuGlyGly+. The decrease in rate at higher pH values is associated with the production of catalytically inactive CuGlyGly complexes produced by the ionization of the peptide hydrogen atom. The mechanism of the reaction is discussed and its possible biological significance considered.

https://doi.org/10.1071/CH9651189

© CSIRO 1965

Committee on Publication Ethics


Export Citation Get Permission

View Dimensions