Liquid-assisted grinding (LAG) approach, metal-free synthesis of 2,3-dihydro-1,5-benzothiazepines and their electrochemical properties
Manjit Singh A , Kuldeep Kumar Maurya A and Manisha Malviya
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Abstract
In this work, we have disclosed a facile metal-free synthesis of pharmaceutically fascinating and biologically important benzothiazepines in the presence of a few drops of ethanol. The present methodology converts chalcones and ortho-amino thiophenol into 2,3-dihydro-1,5-benzothiazepines under ambient conditions using liquid-assisted grinding, resulting in rapid synthesis in a very short period. This process is eco-friendly, operationally simple and gives good to excellent yields of products with easy isolation. This approach offers a facile synthesis of 2,3-dihydro-1,5-benzothiazepines from three readily available starting materials. An electrochemical study of the benzothiazepine derivatives was undertaken using cyclic voltammetry and electrochemical impedance spectroscopy techniques.
Keywords: benzothiazepine, cyclic voltammetry, diffusion coefficient, electrochemical impedance spectroscopy, grinding assisted, mechanochemistry, metal free, one-pot synthesis.
References
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