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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Liquid-assisted grinding (LAG) approach, metal-free synthesis of 2,3-dihydro-1,5-benzothiazepines and their electrochemical properties

Manjit Singh A , Kuldeep Kumar Maurya A and Manisha Malviya https://orcid.org/0000-0002-3559-6268 A *
+ Author Affiliations
- Author Affiliations

A Department of Chemistry, Indian Institute of Technology (IIT), Banaras Hindu University (BHU), Varanasi, India.

* Correspondence to: manisha.apc@itbhu.ac.in

Handling Editor: Paul Bernhardt

Australian Journal of Chemistry 77, CH24006 https://doi.org/10.1071/CH24006
Submitted: 26 January 2024  Accepted: 3 May 2024  Published online: 13 June 2024

© 2024 The Author(s) (or their employer(s)). Published by CSIRO Publishing.

Abstract

In this work, we have disclosed a facile metal-free synthesis of pharmaceutically fascinating and biologically important benzothiazepines in the presence of a few drops of ethanol. The present methodology converts chalcones and ortho-amino thiophenol into 2,3-dihydro-1,5-benzothiazepines under ambient conditions using liquid-assisted grinding, resulting in rapid synthesis in a very short period. This process is eco-friendly, operationally simple and gives good to excellent yields of products with easy isolation. This approach offers a facile synthesis of 2,3-dihydro-1,5-benzothiazepines from three readily available starting materials. An electrochemical study of the benzothiazepine derivatives was undertaken using cyclic voltammetry and electrochemical impedance spectroscopy techniques.

Keywords: benzothiazepine, cyclic voltammetry, diffusion coefficient, electrochemical impedance spectroscopy, grinding assisted, mechanochemistry, metal free, one-pot synthesis.

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