Cobalt(II) catalytic oxidation of arylmethyl sulfonyl imines to arylcarbonyl analogues
Zetao Ma A , Peipei Ma A , Hongli Wu A and Haifeng Gan
A *
A
Abstract
A novel Co(OAc)2/N-hydroxyphthalimide (NHPI)-catalyzed oxidation of 3-arylmethyl sulfonyl imines to prepare 3-arylcarbonyl analogues has been realized. 3-Arylcarbonyl sulfonyl imines were comprehensively synthesized from benzyl substrates for the first time. The reactions proceeded in moderate to excellent yields. Mechanistic investigation suggests that 3-(hydroperoxy(phenyl)methyl)benzo[d]isothiazole 1,1-dioxide A is the key intermediate for the formation of products 2.
Keywords: Co(OAc)2, dioxygen, mechanism, NHPI, oxidation, pharmaceutical, radical, sulfonyl imines.
References
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