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REVIEW (Open Access)
Contents Vol 75(2)

Radiolabelled Peptides: Optimal Candidates for Theranostic Application in Oncology

Andrew J. Hall A and Mohammad B. Haskali https://orcid.org/0000-0003-3084-2084 A B C
+ Author Affiliations
- Author Affiliations

A Radiopharmaceutical Research Laboratory, The Peter MacCallum Cancer Centre, Melbourne, Vic. 3000, Australia.

B Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic. 3010, Australia.

C Corresponding author. Email: mo.haskali@petermac.org




Dr Mohammad Haskali is a radiopharmaceutical scientist (RPS) certified by the Australasian College of Physical Scientists and Engineers in Medicine in their A1 limited category. After receiving his PhD degree in the development of research radiopharmaceuticals and radiochemistry methodologies, he gained extensive experience in the radiopharmaceutical industry operating under the code of Good Manufacturing Practice (GMP) before joining the National Institute of Mental Health (NIMH) in the USA as a radiochemist. Currently, Dr Haskali is employed by the Peter MacCallum Cancer Centre in Melbourne where he is involved in radiopharmaceutical science research and the provision of radiopharmaceuticals for clinical use.

Australian Journal of Chemistry 75(2) 34-54 https://doi.org/10.1071/CH21118
Submitted: 20 May 2021  Accepted: 21 September 2021   Published: 8 November 2021

Journal Compilation © CSIRO 2022 Open Access CC BY-NC-ND

Abstract

Theranostics are drugs suitable for use in both diagnostic and therapeutic applications, and have played an important role in the advancement of modern nuclear medicine. This review explains key elements that are common to successful theranostics and highlights significant developments in the field, including our own. Specific focus is given to peptides and those features that make them most suitable for theranostic application, as well as some key radioisotopes owing to their favourable properties and high clinical utility. This report provides an overview of the techniques at the researcher’s disposal, how they have been applied to current clinically significant targets, and how they might be used and improved upon for future targets.

Keywords: theranostic, radiopharmaceutical, radiolabelling, peptide, foldamers, oncology, RNT, PET, PRRT, radionuclide.


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