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REVIEW (Open Access)
Contents Vol 75(2)

Radiolabelled Peptides: Optimal Candidates for Theranostic Application in Oncology

Andrew J. Hall A and Mohammad B. Haskali https://orcid.org/0000-0003-3084-2084 A B C
+ Author Affiliations
- Author Affiliations

A Radiopharmaceutical Research Laboratory, The Peter MacCallum Cancer Centre, Melbourne, Vic. 3000, Australia.

B Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic. 3010, Australia.

C Corresponding author. Email: mo.haskali@petermac.org




Dr Mohammad Haskali is a radiopharmaceutical scientist (RPS) certified by the Australasian College of Physical Scientists and Engineers in Medicine in their A1 limited category. After receiving his PhD degree in the development of research radiopharmaceuticals and radiochemistry methodologies, he gained extensive experience in the radiopharmaceutical industry operating under the code of Good Manufacturing Practice (GMP) before joining the National Institute of Mental Health (NIMH) in the USA as a radiochemist. Currently, Dr Haskali is employed by the Peter MacCallum Cancer Centre in Melbourne where he is involved in radiopharmaceutical science research and the provision of radiopharmaceuticals for clinical use.

Australian Journal of Chemistry 75(2) 34-54 https://doi.org/10.1071/CH21118
Submitted: 20 May 2021  Accepted: 21 September 2021   Published: 8 November 2021

Journal Compilation © CSIRO 2022 Open Access CC BY-NC-ND

Abstract

Theranostics are drugs suitable for use in both diagnostic and therapeutic applications, and have played an important role in the advancement of modern nuclear medicine. This review explains key elements that are common to successful theranostics and highlights significant developments in the field, including our own. Specific focus is given to peptides and those features that make them most suitable for theranostic application, as well as some key radioisotopes owing to their favourable properties and high clinical utility. This report provides an overview of the techniques at the researcher’s disposal, how they have been applied to current clinically significant targets, and how they might be used and improved upon for future targets.

Keywords: theranostic, radiopharmaceutical, radiolabelling, peptide, foldamers, oncology, RNT, PET, PRRT, radionuclide.


References

[1]  S. S. Kelkar, T. M. Reineke, Bioconjug. Chem. 2011, 22, 1879.
         | Crossref | GoogleScholarGoogle Scholar | 21830812PubMed |

[2]  S. S. Gambhir, Nat. Rev. Cancer 2002, 2, 683.
         | Crossref | GoogleScholarGoogle Scholar | 12209157PubMed |

[3]  C. S. Cutler, H. M. Hennkens, N. Sisay, S. Huclier-Markai, S. S. Jurisson, Chem. Rev. 2013, 113, 858.
         | Crossref | GoogleScholarGoogle Scholar | 23198879PubMed |

[4]  L. G. Milroy, T. N. Grossmann, S. Hennig, L. Brunsveld, C. Ottmann, Chem. Rev. 2014, 114, 4695.
         | Crossref | GoogleScholarGoogle Scholar | 24735440PubMed |

[5]  A. C.-L. Lee, J. L. Harris, K. K. Khanna, J.-H. Hong, Int. J. Mol. Sci. 2019, 20, 2383.
         | Crossref | GoogleScholarGoogle Scholar |

[6]  S. Asati, V. Pandey, V. Soni, Int. J. Pept. Res. Ther. 2019, 25, 49.
         | Crossref | GoogleScholarGoogle Scholar |

[7]  V. Ambrosini, M. Fani, S. Fanti, F. Forrer, H. R. Maecke, J. Nucl. Med. 2011, 52, 42S.
         | Crossref | GoogleScholarGoogle Scholar | 22144555PubMed |

[8]  C. A. Lipinski, F. Lombardo, B. W. Dominy, P. J. Feeney, Adv. Drug Deliv. Rev. 1997, 23, 3.
         | Crossref | GoogleScholarGoogle Scholar |

[9]  A. K. Ghose, V. N. Viswanadhan, J. J. Wendoloski, J. Comb. Chem. 1999, 1, 55.
         | Crossref | GoogleScholarGoogle Scholar | 10746014PubMed |

[10]  R. N. Waterhouse, Mol. Imaging Biol. 2003, 5, 376.
         | Crossref | GoogleScholarGoogle Scholar | 14667492PubMed |

[11]  V. W. Pike, Curr. Med. Chem. 2016, 23, 1818.
         | Crossref | GoogleScholarGoogle Scholar | 27087244PubMed |

[12]  M. Schottelius, J. Šimeček, F. Hoffmann, M. Willibald, M. Schwaiger, H.-J. Wester, EJNMMI Res. 2015, 5, 22.
         | Crossref | GoogleScholarGoogle Scholar | 25918675PubMed |

[13]  A.-C. Baranski, M. Schäfer, U. Bauder-Wüst, M. Roscher, J. Schmidt, E. Stenau, T. Simpfendörfer, D. Teber, L. Maier-Hein, B. Hadaschik, U. Haberkorn, M. Eder, K. Kopka, J. Nucl. Med. 2018, 59, 639.
         | Crossref | GoogleScholarGoogle Scholar | 29191856PubMed |

[14]  S. Robu, A. Schmidt, M. Eiber, M. Schottelius, T. Günther, B. Hooshyar Yousefi, M. Schwaiger, H.-J. Wester, EJNMMI Res. 2018, 8, 30.
         | Crossref | GoogleScholarGoogle Scholar | 29651565PubMed |

[15]  M. Benešová, C. A. Umbricht, R. Schibli, C. Müller, Mol. Pharm. 2018, 15, 934.
         | Crossref | GoogleScholarGoogle Scholar | 29400475PubMed |

[16]  A. Poschenrieder, M. Schottelius, M. Schwaiger, H. Kessler, H. J. Wester, EJNMMI Res. 2016, 6, 36.
         | 27112767PubMed |

[17]  M. Schottelius, T. Osl, A. Poschenrieder, F. Hoffmann, S. Beykan, H. Hänscheid, A. Schirbel, A. K. Buck, S. Kropf, M. Schwaiger, U. Keller, M. Lassmann, H.-J. Wester, Theranostics 2017, 7, 2350.
         | Crossref | GoogleScholarGoogle Scholar | 28744319PubMed |

[18]  K. Pohle, J. Notni, J. Bussemer, H. Kessler, M. Schwaiger, A. J. Beer, Nucl. Med. Biol. 2012, 39, 777.
         | Crossref | GoogleScholarGoogle Scholar | 22444238PubMed |

[19]  Z. Wu, Z. B. Li, K. Chen, W. Cai, L. He, F. T. Chin, F. Li, X. Chen, J. Nucl. Med. 2007, 48, 1536.
         | Crossref | GoogleScholarGoogle Scholar | 17704249PubMed |

[20]  M. Maurin, P. Garnuszek, P. Baran, D. Pawlak, R. Mikołajczak, Nucl. Med. Rev. 2015, 18, 51.
         | Crossref | GoogleScholarGoogle Scholar |

[21]  J. Toms, J. Kogler, S. Maschauer, C. Daniel, C. Schmidkonz, T. Kuwert, O. Prante, J. Nucl. Med. 2020, 61, 1806.
         | Crossref | GoogleScholarGoogle Scholar | 32332144PubMed |

[22]  M. Benesová, M. Schäfer, U. Bauder-Wüst, A. Afshar-Oromieh, C. Kratochwil, W. Mier, U. Haberkorn, K. Kopka, M. Eder, J. Nucl. Med. 2015, 56, 914.
         | Crossref | GoogleScholarGoogle Scholar | 25883127PubMed |

[23]  E. Vegt, M. de Jong, J. F. Wetzels, R. Masereeuw, M. Melis, W. J. Oyen, M. Gotthardt, O. C. Boerman, J. Nucl. Med. 2010, 51, 1049.
         | Crossref | GoogleScholarGoogle Scholar | 20554737PubMed |

[24]  N. Sarvilinna, H. Eronen, S. Miettinen, A. Vienonen, T. Ylikomi, Int. J. Cancer 2006, 118, 832.
         | Crossref | GoogleScholarGoogle Scholar | 16152593PubMed |

[25]  G. P. V. Reddy, E. R. Barrack, Q. P. Dou, M. Menon, R. Pelley, F. H. Sarkar, S. Sheng, J. Cell. Biochem. 2006, 98, 1408.
         | Crossref | GoogleScholarGoogle Scholar |

[26]  D. Kwekkeboom, E. P. Krenning, M. De Jong, J. Nucl. Med. 2000, 41, 1704.
         | 11038002PubMed |

[27]  J. C. Reubi, J. C. Schär, B. Waser, S. Wenger, A. Heppeler, J. S. Schmitt, H. R. Mäcke, Eur. J. Nucl. Med. 2000, 27, 273.
         | Crossref | GoogleScholarGoogle Scholar | 10774879PubMed |

[28]  J. C. Reubi, Endocr. Rev. 2003, 24, 389.
         | Crossref | GoogleScholarGoogle Scholar | 12920149PubMed |

[29]  Y. C. Patel, Front. Neuroendocrinol. 1999, 20, 157.
         | Crossref | GoogleScholarGoogle Scholar | 10433861PubMed |

[30]  A. G. Harris, Gut 1994, 35, S1.
         | Crossref | GoogleScholarGoogle Scholar | 7911441PubMed |

[31]  W. Bauer, U. Briner, W. Doepfner, R. Haller, R. Huguenin, P. Marbach, T. J. Petcher, J. Pless, Life Sci. 1982, 31, 1133.
         | Crossref | GoogleScholarGoogle Scholar | 6128648PubMed |

[32]  W. H. Bakker, R. Albert, C. Bruns, W. A. P. Breeman, L. J. Hofland, P. Marbach, J. Pless, D. Pralet, B. Stolz, J. W. Koper, S. W. J. Lamberts, T. J. Visser, E. P. Krenning, Life Sci. 1991, 49, 1583.
         | Crossref | GoogleScholarGoogle Scholar | 1658515PubMed |

[33]  M. De Jong, W. A. P. Breeman, W. H. Bakker, P. P. M. Kooij, B. F. Bernard, L. J. Hofland, T. J. Visser, A. Srinivasan, M. A. Schmidt, J. L. Erion, J. E. Bugaj, H. R. Mäcke, E. P. Krenning, Cancer Res. 1998, 58, 437.
         | 9458086PubMed |

[34]  W. H. Bakker, E. P. Krenning, W. A. Breeman, J. W. Koper, P. P. Kooij, J.-C. Reubi, J. G. Klijn, T. J. Visser, R. Docter, S. W. Lamberts, J. Nucl. Med. 1990, 31, 1501.
         | 1975618PubMed |

[35]  D. J. Kwekkeboom, W. H. Bakker, P. P. Kooij, M. W. Konijnenberg, A. Srinivasan, J. L. Erion, M. A. Schmidt, J. L. Bugaj, M. De Jong, E. P. Krenning, Eur. J. Nucl. Med. 2001, 28, 1319.
         | Crossref | GoogleScholarGoogle Scholar | 11585290PubMed |

[36]  J. S. Lewis, M. Wang, R. Laforest, F. Wang, J. L. Erion, J. E. Bugaj, A. Srinivasan, C. J. Anderson, Int. J. Cancer 2001, 94, 873.
         | Crossref | GoogleScholarGoogle Scholar | 11745491PubMed |

[37]  M. De Jong, W. A. P. Breeman, B. F. Bernard, W. H. Bakker, M. Schaar, A. van Gameren, J. E. Bugaj, J. Erion, M. Schmidt, A. Srinivasan, E. P. Krenning, Int. J. Cancer 2001, 92, 628.
         | Crossref | GoogleScholarGoogle Scholar | 11340564PubMed |

[38]  R. J. Hicks, Cancer Imaging 2010, 10, S83.
         | Crossref | GoogleScholarGoogle Scholar | 20880795PubMed |

[39]  J. Strosberg, G. El-Haddad, E. Wolin, A. Hendifar, J. Yao, B. Chasen, E. Mittra, P. L. Kunz, M. H. Kulke, H. Jacene, D. Bushnell, T. M. O’Dorisio, R. P. Baum, H. R. Kulkarni, M. Caplin, R. Lebtahi, T. Hobday, E. Delpassand, E. Van Cutsem, A. Benson, R. Srirajaskanthan, M. Pavel, J. Mora, J. Berlin, E. Grande, N. Reed, E. Seregni, K. Öberg, M. L. Sierra, P. Santoro, T. Thevenet, J. L. Erion, P. Ruszniewski, D. Kwekkeboom, E. Krenning, N. Engl. J. Med. 2017, 376, 125.
         | Crossref | GoogleScholarGoogle Scholar | 28076709PubMed |

[40]  A. Ghosh, W. D. W. Heston, J. Cell. Biochem. 2004, 91, 528.
         | Crossref | GoogleScholarGoogle Scholar | 14755683PubMed |

[41]  A. Ghosh, W. D. W. Heston, in The Oncogenomics Handbook (Eds W. J. LaRochelle, R. A. Shimkets) 2005, pp. 597–615 (Humana Press: Totowa, NJ).

[42]  M. Perera, N. Papa, D. Christidis, D. Wetherell, M. S. Hofman, D. G. Murphy, D. Bolton, N. Lawrentschuk, Eur. Urol. 2016, 70, 926.
         | Crossref | GoogleScholarGoogle Scholar | 27363387PubMed |

[43]  P. F. Jackson, D. C. Cole, B. S. Slusher, S. L. Stetz, L. E. Ross, B. A. Donzanti, D. A. Trainor, J. Med. Chem. 1996, 39, 619.
         | Crossref | GoogleScholarGoogle Scholar | 8558536PubMed |

[44]  A. P. Kozikowski, F. Nan, P. Conti, J. Zhang, E. Ramadan, T. Bzdega, B. Wroblewska, J. H. Neale, S. Pshenichkin, J. T. Wroblewski, J. Med. Chem. 2001, 44, 298.
         | Crossref | GoogleScholarGoogle Scholar | 11462970PubMed |

[45]  E. Eppard, A. Fuente, M. Benešová, A. Khawar, R. Bundschuh, F. Gaertner, B. Kreppel, K. Kopka, M. Essler, F. Roesch, Theranostics 2017, 7, 4359.
         | Crossref | GoogleScholarGoogle Scholar | 29158832PubMed |

[46]  A.-C. Baranski, M. Schäfer, U. Bauder-Wüst, A. Wacker, J. Schmidt, C. Liolios, W. Mier, U. Haberkorn, M. Eisenhut, K. Kopka, M. Eder, Bioconjug. Chem. 2017, 28, 2485.
         | Crossref | GoogleScholarGoogle Scholar | 28787147PubMed |

[47]  H.-T. Kuo, J. Pan, Z. Zhang, J. Lau, H. Merkens, C. Zhang, N. Colpo, K.-S. Lin, F. Bénard, Mol. Pharm. 2018, 15, 3502.
         | Crossref | GoogleScholarGoogle Scholar | 29920108PubMed |

[48]  M. Benešová, U. Bauder-Wüst, M. Schäfer, K. D. Klika, W. Mier, U. Haberkorn, K. Kopka, M. Eder, J. Med. Chem. 2016, 59, 1761.
         | Crossref | GoogleScholarGoogle Scholar | 26878194PubMed |

[49]  T. Liu, J. R. Nedrow-Byers, M. R. Hopkins, C. E. Berkman, Bioorg. Med. Chem. Lett. 2011, 21, 7013.
         | Crossref | GoogleScholarGoogle Scholar | 22018464PubMed |

[50]  United States Food and Drug Administration, FDA approves second PSMA-targeted PET imaging drug for men with prostate cancer. Drug Safety and Availability 2021. Available at: https://www.fda.gov/drugs/drug-safety-and-availability/fda-approves-second-psma-targeted-pet-imaging-drug-men-prostate-cancer

[51]  M. S. Hofman, N. Lawrentschuk, R. J. Francis, C. Tang, I. Vela, P. Thomas, N. Rutherford, J. M. Martin, M. Frydenberg, R. Shakher, L.-M. Wong, K. Taubman, S. T. Lee, E. Hsiao, P. Roach, M. Nottage, I. Kirkwood, D. Hayne, E. Link, P. Marusic, A. Matera, A. Herschtal, A. Iravani, R. J. Hicks, S. Williams, D. G. Murphy, Lancet 2020, 395, 1208.
         | Crossref | GoogleScholarGoogle Scholar | 32209449PubMed |

[52]  M. S. Hofman, J. Violet, R. J. Hicks, J. Ferdinandus, S. Ping Thang, T. Akhurst, A. Iravani, G. Kong, A. Ravi Kumar, D. G. Murphy, P. Eu, P. Jackson, M. Scalzo, S. G. Williams, S. Sandhu, Lancet Oncol. 2018, 19, 825.
         | Crossref | GoogleScholarGoogle Scholar | 29752180PubMed |

[53]  M. S. Hofman, L. Emmett, S. Sandhu, A. Iravani, A. M. Joshua, J. C. Goh, D. A. Pattison, T. H. Tan, I. D. Kirkwood, S. Ng, R. J. Francis, C. Gedye, N. K. Rutherford, A. Weickhardt, A. M. Scott, S.-T. Lee, E. M. Kwan, A. A. Azad, S. Ramdave, A. D. Redfern, W. Macdonald, A. Guminski, E. Hsiao, W. Chua, P. Lin, A. Y. Zhang, M. M. McJannett, M. R. Stockler, J. A. Violet, S. G. Williams, A. J. Martin, I. D. Davis, A. A. Azad, W. Chua, I. D. Davis, N. Dhiantravan, L. Emmett, K. Ford, N. Rana, S. Yip, Lancet 2021, 397, 797.
         | Crossref | GoogleScholarGoogle Scholar | 33581798PubMed |

[54]  J. C. Reubi, J.-C. Schaer, B. Waser, Cancer Res. 1997, 57, 1377.
         | 9102227PubMed |

[55]  J. C. Reubi, B. Waser, Int. J. Cancer 1996, 67, 644.
         | Crossref | GoogleScholarGoogle Scholar | 8782652PubMed |

[56]  C. Chao, X. Han, K. Ives, J. Park, A. A. Kolokoltsov, R. A. Davey, M. P. Moyer, M. R. Hellmich, Int. J. Cancer 2010, 126, 864.
         | 19697327PubMed |

[57]  M. B. Haskali, P. D. Roselt, D. Binns, A. Hetsron, S. Poniger, C. A. Hutton, R. J. Hicks, EJNMMI Radiopharm. Chem. 2019, 4, 23.
         | Crossref | GoogleScholarGoogle Scholar | 31659509PubMed |

[58]  M. Béhé, G. Kluge, W. Becker, M. Gotthardt, T. M. Behr, J. Nucl. Med. 2005, 46, 1012.
         | 15937313PubMed |

[59]  P. Laverman, L. Joosten, A. Eek, S. Roosenburg, P. K. Peitl, T. Maina, H. Mäcke, L. Aloj, E. von Guggenberg, J. K. Sosabowski, M. de Jong, J.-C. Reubi, W. J. G. Oyen, O. C. Boerman, Eur. J. Nucl. Med. Mol. Imaging 2011, 38, 1410.
         | Crossref | GoogleScholarGoogle Scholar | 21461732PubMed |

[60]  S. Roosenburg, P. Laverman, F. L. Van Delft, O. C. Boerman, Amino Acids 2011, 41, 1049.
         | Crossref | GoogleScholarGoogle Scholar | 20198494PubMed |

[61]  T. M. Behr, N. Jenner, M. Béhé, C. Angerstein, S. Gratz, F. Raue, W. Becker, J. Nucl. Med. 1999, 40, 1029.
         | 10452322PubMed |

[62]  L. Aloj, M. Aurilio, V. Rinaldi, L. D’ambrosio, D. Tesauro, P. K. Peitl, T. Maina, R. Mansi, E. von Guggenberg, L. Joosten, J. K. Sosabowski, W. A. P. Breeman, E. De Blois, S. Koelewijn, M. Melis, B. Waser, K. Beetschen, J. C. Reubi, M. de Jong, Eur. J. Nucl. Med. Mol. Imaging 2011, 38, 1417.
         | Crossref | GoogleScholarGoogle Scholar | 21523391PubMed |

[63]  M. Ocak, A. Helbok, C. Rangger, P. K. Peitl, B. A. Nock, G. Morelli, A. Eek, J. K. Sosabowski, W. A. P. Breeman, J. C. Reubi, C. Decristoforo, Eur. J. Nucl. Med. Mol. Imaging 2011, 38, 1426.
         | Crossref | GoogleScholarGoogle Scholar | 21528387PubMed |

[64]  M. Klingler, D. Summer, C. Rangger, R. Haubner, J. Foster, J. Sosabowski, C. Decristoforo, I. Virgolini, E. Von Guggenberg, J. Nucl. Med. 2019, 60, 1010.
         | Crossref | GoogleScholarGoogle Scholar | 30530828PubMed |

[65]  C. Uprimny, E. von Guggenberg, A. Svirydenka, R. Mikołajczak, A. Hubalewska-Dydejczyk, I. J. Virgolini, Eur. J. Nucl. Med. Mol. Imaging 2021, 48, 935.
         | Crossref | GoogleScholarGoogle Scholar | 32748048PubMed |

[66]  X. Li, H. Cai, X. Wu, L. Li, H. Wu, R. Tian, Front Chem. 2020, 8, 583309.
         | 33335885PubMed |

[67]  H. Chen, G. Niu, H. Wu, X. Chen, Theranostics 2016, 6, 78.
         | Crossref | GoogleScholarGoogle Scholar | 26722375PubMed |

[68]  M. Kircher, P. Herhaus, M. Schottelius, A. K. Buck, R. A. Werner, H.-J. Wester, U. Keller, C. Lapa, Ann. Nucl. Med. 2018, 32, 503.
         | Crossref | GoogleScholarGoogle Scholar | 30105558PubMed |

[69]  P. Windisch, D. R. Zwahlen, S. A. Koerber, F. L. Giesel, J. Debus, U. Haberkorn, S. Adeberg, Cancers (Basel) 2020, 12, 2629.

[70]  T. J. P. Jansen, S. A. M. van Lith, M. Boss, M. Brom, L. Joosten, M. Béhé, M. Buitinga, M. Gotthardt, J. Labelled Comp. Radiopharm. 2019, 62, 656.
         | Crossref | GoogleScholarGoogle Scholar |

[71]  C. E. A. Chang, W. Chen, M. K. Gilson, Proc. Natl. Acad. Sci. USA 2007, 104, 1534.
         | Crossref | GoogleScholarGoogle Scholar |

[72]  K. Bozovičar, T. Bratkovič, Int. J. Mol. Sci. 2021, 22, 1611.
         | Crossref | GoogleScholarGoogle Scholar | 33562633PubMed |

[73]  H. Yin, ISRN Biochem. 2012, 2012, 692190.
         | Crossref | GoogleScholarGoogle Scholar | 25969758PubMed |

[74]  D. H. Appella, L. A. Christianson, I. L. Karle, D. R. Powell, S. H. Gellman, J. Am. Chem. Soc. 1996, 118, 13071.
         | Crossref | GoogleScholarGoogle Scholar |

[75]  S. H. Gellman, Acc. Chem. Res. 1998, 31, 173.
         | Crossref | GoogleScholarGoogle Scholar |

[76]  R. Gopalakrishnan, A. I. Frolov, L. Knerr, W. J. Drury, E. Valeur, J. Med. Chem. 2016, 59, 9599.
         | Crossref | GoogleScholarGoogle Scholar | 27362955PubMed |

[77]  G. N. Ramachandran, C. Ramakrishnan, V. Sasisekharan, J. Mol. Biol. 1963, 7, 95.
         | Crossref | GoogleScholarGoogle Scholar | 13990617PubMed |

[78]  O. Khakshoor, B. Demeler, J. S. Nowick, J. Am. Chem. Soc. 2007, 129, 5558.
         | Crossref | GoogleScholarGoogle Scholar | 17419629PubMed |

[79]  J. S. Davies, J. Pept. Sci. 2003, 9, 471.
         | Crossref | GoogleScholarGoogle Scholar | 12952390PubMed |

[80]  V. J. Hruby, Nat. Rev. Drug Discov. 2002, 1, 847.
         | Crossref | GoogleScholarGoogle Scholar | 12415245PubMed |

[81]  M. A. Dechantsreiter, E. Planker, B. Mathä, E. Lohof, G. Hölzemann, A. Jonczyk, S. L. Goodman, H. Kessler, J. Med. Chem. 1999, 42, 3033.
         | Crossref | GoogleScholarGoogle Scholar | 10447947PubMed |

[82]  K. Temming, R. M. Schiffelers, G. Molema, R. J. Kok, Drug Resist. Updates 2005, 8, 381.
         | Crossref | GoogleScholarGoogle Scholar |

[83]  O. Demmer, E. Gourni, U. Schumacher, H. Kessler, H. J. Wester, ChemMedChem 2011, 6, 1789.
         | Crossref | GoogleScholarGoogle Scholar | 21780290PubMed |

[84]  J. Rivier, M. Brown, W. Vale, Biochem. Biophys. Res. Commun. 1975, 65, 746.
         | Crossref | GoogleScholarGoogle Scholar | 1096897PubMed |

[85]  C. A. Rhodes, D. Pei, Chemistry (Easton) 2017, 23, 12690.

[86]  P. Timmerman, J. Beld, W. C. Puijk, R. H. Meloen, ChemBioChem 2005, 6, 821.
         | Crossref | GoogleScholarGoogle Scholar | 15812852PubMed |

[87]  S. Chen, J. Morales-Sanfrutos, A. Angelini, B. Cutting, C. Heinis, ChemBioChem 2012, 13, 1032.
         | Crossref | GoogleScholarGoogle Scholar | 22492661PubMed |

[88]  C. Ernst, J. Sindlinger, D. Schwarzer, P. Koch, F. M. Boeckler, ACS Omega 2018, 3, 12361.
         | Crossref | GoogleScholarGoogle Scholar | 30411004PubMed |

[89]  M. Fani, A. Mueller, M. L. Tamma, G. Nicolas, H. R. Rink, R. Cescato, J. C. Reubi, H. R. Maecke, J. Nucl. Med. 2010, 51, 1771.
         | Crossref | GoogleScholarGoogle Scholar | 20956465PubMed |

[90]  D. F. Veber, F. W. Holly, W. J. Paleveda, R. F. Nutt, S. J. Bergstrand, M. Torchiana, M. S. Glitzer, R. Saperstein, R. Hirschmann, Proc. Natl. Acad. Sci. USA 1978, 75, 2636.
         | Crossref | GoogleScholarGoogle Scholar | 208068PubMed |

[91]  E. Falb, Y. Salitra, T. Yechezkel, M. Bracha, P. Litman, R. Olender, R. Rosenfeld, H. Senderowitz, S. Jiang, M. Goodman, Bioorg. Med. Chem. 2001, 9, 3255.
         | Crossref | GoogleScholarGoogle Scholar | 11711301PubMed |

[92]  M. Eder, S. Pavan, U. Bauder-Wüst, K. van Rietschoten, A. C. Baranski, H. Harrison, S. Campbell, C. L. Stace, E. H. Walker, L. Chen, G. Bennett, G. Mudd, U. Schierbaum, K. Leotta, U. Haberkorn, K. Kopka, D. P. Teufel, Cancer Res. 2019, 79, 841.
         | Crossref | GoogleScholarGoogle Scholar | 30606721PubMed |

[93]  D. H. Coy, N. Y. Jiang, S. H. Kim, J. P. Moreau, J. T. Lin, H. Frucht, J. M. Qian, L. W. Wang, R. T. Jensen, J. Biol. Chem. 1991, 266, 16441.
         | Crossref | GoogleScholarGoogle Scholar | 1715866PubMed |

[94]  L. M. Johnson, S. Barrick, M. V. Hager, A. McFedries, E. A. Homan, M. E. Rabaglia, M. P. Keller, A. D. Attie, A. Saghatelian, A. Bisello, S. H. Gellman, J. Am. Chem. Soc. 2014, 136, 12848.
         | Crossref | GoogleScholarGoogle Scholar | 25191938PubMed |

[95]  A. M. Ali, J. Atmaj, N. Van Oosterwijk, M. R. Groves, A. Dömling, Comput. Struct. Biotechnol. J. 2019, 17, 263.
         | Crossref | GoogleScholarGoogle Scholar | 30867891PubMed |

[96]  C. E. Schafmeister, J. Po, G. L. Verdine, J. Am. Chem. Soc. 2000, 122, 5891.
         | Crossref | GoogleScholarGoogle Scholar |

[97]  H. E. Blackwell, R. H. Grubbs, Angew. Chem. Int. Ed. 1998, 37, 3281.
         | Crossref | GoogleScholarGoogle Scholar |

[98]  N. E. Shepherd, H. N. Hoang, G. Abbenante, D. P. Fairlie, J. Am. Chem. Soc. 2005, 127, 2974.
         | Crossref | GoogleScholarGoogle Scholar | 15740134PubMed |

[99]  A. M. Spokoyny, Y. Zou, J. J. Ling, H. Yu, Y. S. Lin, B. L. Pentelute, J. Am. Chem. Soc. 2013, 135, 5946.
         | Crossref | GoogleScholarGoogle Scholar | 23560559PubMed |

[100]  N. Assem, D. J. Ferreira, D. W. Wolan, P. E. Dawson, Angew. Chem. Int. Ed. 2015, 54, 8665.
         | Crossref | GoogleScholarGoogle Scholar |

[101]  F. M. Brunel, P. E. Dawson, Chem. Commun. 2005, 2552.
         | Crossref | GoogleScholarGoogle Scholar |

[102]  G. J. Hilinski, Y. W. Kim, J. Hong, P. S. Kutchukian, C. M. Crenshaw, S. S. Berkovitch, A. Chang, S. Ham, G. L. Verdine, J. Am. Chem. Soc. 2014, 136, 12314.
         | Crossref | GoogleScholarGoogle Scholar | 25105213PubMed |

[103]  M. Pelay-Gimeno, A. Glas, O. Koch, T. N. Grossmann, Angew. Chem. Int. Ed. 2015, 54, 8896.
         | Crossref | GoogleScholarGoogle Scholar |

[104]  D. H. Appella, L. A. Christianson, D. A. Klein, D. R. Powell, X. Huang, J. J. Barchi, S. H. Gellman, Nature 1997, 387, 381.
         | Crossref | GoogleScholarGoogle Scholar | 9163422PubMed |

[105]  D. Ghosh, P. Lahiri, H. Verma, S. Mukherjee, J. Chatterjee, Chem. Sci. 2016, 7, 5212.
         | Crossref | GoogleScholarGoogle Scholar | 29449932PubMed |

[106]  W. G. Lesniak, E. Sikorska, H. Shallal, B. Behnam Azad, A. Lisok, M. Pullambhatla, M. G. Pomper, S. Nimmagadda, Mol. Pharm. 2015, 12, 941.
         | Crossref | GoogleScholarGoogle Scholar | 25590535PubMed |

[107]  A. C. Gibbs, T. C. Bjorndahl, R. S. Hodges, D. S. Wishart, J. Am. Chem. Soc. 2002, 124, 1203.
         | Crossref | GoogleScholarGoogle Scholar | 11841288PubMed |

[108]  A. G. Cochran, N. J. Skelton, M. A. Starovasnik, Proc. Natl. Acad. Sci. USA 2001, 98, 5578.
         | Crossref | GoogleScholarGoogle Scholar | 11331745PubMed |

[109]  K. Wang, Y. Song, Y. Su, Y. Liang, L. Wang, Biochem. Biophys. Res. Commun. 2020, 527, 453.
         | Crossref | GoogleScholarGoogle Scholar | 32336542PubMed |

[110]  A. Corlett, M.-A. Sani, J. Van Zuylekom, C.-S. Ang, E. von Guggenberg, C. Cullinane, B. Blyth, R. J. Hicks, P. D. Roselt, P. E. Thompson, C. A. Hutton, M. B. Haskali, J. Med. Chem. 2021, 64, 4841.
         | 33826325PubMed |

[111]  S. Boschi, F. Lodi, in Basic Science of PET Imaging (Ed. M. Khalil) 2017, pp. 79–103 (Springer: Cham).

[112]  P. W. Miller, N. J. Long, R. Vilar, A. D. Gee, Angew. Chem. Int. Ed. 2008, 47, 8998.
         | Crossref | GoogleScholarGoogle Scholar |

[113]  S. Liu, D. S. Edwards, Chem. Rev. 1999, 99, 2235.
         | Crossref | GoogleScholarGoogle Scholar | 11749481PubMed |

[114]  M. M. Be, V. Chiste, C. Dulieu, E. Browne, V. Chechev, N. Kuzmenko, R. Helmer, A. Nichols, E. Schonfeld, R. Dersch, Table of Radionuclides 2004 (Bureau International des Poids et Mesures: France).

[115]  A. Gopalakrishna, S. V. Suryanarayana, H. Naik, T. S. Dixit, B. K. Nayak, A. Kumar, P. Maletha, K. Thakur, A. Deshpande, R. Krishnan, K. Kamaldeep, S. Banerjee, A. Saxena, Radiochim. Acta 2018, 106, 549.
         | Crossref | GoogleScholarGoogle Scholar |

[116]  F. F. Knapp, M. M. Goodman, A. P. Callahan, L. A. Ferren, G. W. Kabalka, K. A. R. Sastry, J. Med. Chem. 1983, 26, 1293.
         | Crossref | GoogleScholarGoogle Scholar | 6887204PubMed |

[117]  M. M. Be, V. Chiste, C. Dulieu, M. A. Kellett, X. Mougeot, A. Arinc, V. P. Chechev, N. K. Kuzmenko, T. Kibedi, A. Luca, A. L. Nichols, Table of Radionuclides 2016 (Bureau International des Poids et Mesures: France).

[118]  R. A. Werner, C. Bluemel, M. S. Allen-Auerbach, T. Higuchi, K. Herrmann, Ann. Nucl. Med. 2015, 29, 1.
         | Crossref | GoogleScholarGoogle Scholar | 25139472PubMed |

[119]  W. Jones, K. Griffiths, P. C. Barata, C. J. Paller, Cancers (Basel) 2020, 12, 1367.
         | Crossref | GoogleScholarGoogle Scholar |

[120]  R. A. Werner, T. Derlin, C. Lapa, S. Sheikbahaei, T. Higuchi, F. L. Giesel, S. Behr, A. Drzezga, H. Kimura, A. K. Buck, F. M. Bengel, M. G. Pomper, M. A. Gorin, S. P. Rowe, Theranostics 2020, 10, 1.
         | Crossref | GoogleScholarGoogle Scholar | 31903102PubMed |

[121]  K. Rahbar, A. Afshar-Oromieh, H. Jadvar, H. Ahmadzadehfar, Mol. Imaging 2018, 17, 1.
         | Crossref | GoogleScholarGoogle Scholar |

[122]  P. M. Smith-Jones, B. Stolz, R. Albert, H. Knecht, C. Bruns, Nucl. Med. Biol. 1997, 24, 761.
         | Crossref | GoogleScholarGoogle Scholar | 9428603PubMed |

[123]  R. Haubner, H. J. Wester, F. Burkhart, R. Senekowitsch-Schmidtke, W. Weber, S. L. Goodman, H. Kessler, M. Schwaiger, J. Nucl. Med. 2001, 42, 326.
         | 11216533PubMed |

[124]  X. Chen, R. Park, A. H. Shahinian, J. R. Bading, P. S. Conti, Nucl. Med. Biol. 2004, 31, 11.
         | Crossref | GoogleScholarGoogle Scholar | 14741566PubMed |

[125]  I. Dijkgraaf, S. Liu, J. A. W. Kruijtzer, A. C. Soede, W. J. G. Oyen, R. M. J. Liskamp, F. H. M. Corstens, O. C. Boerman, Nucl. Med. Biol. 2007, 34, 29.
         | Crossref | GoogleScholarGoogle Scholar | 17210459PubMed |

[126]  P. Laverman, W. J. McBride, R. M. Sharkey, A. Eek, L. Joosten, W. J. G. Oyen, D. M. Goldenberg, O. C. Boerman, J. Nucl. Med. 2010, 51, 454.
         | Crossref | GoogleScholarGoogle Scholar | 20150268PubMed |

[127]  M. W. Brechbiel, Q. J. Nucl. Med. Mol. Imaging 2008, 52, 166.
         | 18043537PubMed |

[128]  E. W. Price, C. Orvig, Chem. Soc. Rev. 2014, 43, 260.
         | Crossref | GoogleScholarGoogle Scholar | 24173525PubMed |

[129]  S. Liu, Adv. Drug Deliv. Rev. 2008, 60, 1347.
         | Crossref | GoogleScholarGoogle Scholar | 18538888PubMed |

[130]  M. M. Be, V. Chiste, C. Dulieu, X. Mougeot, V. P. Chechev, F. G. Kondev, A. L. Nichols, X. Huang, B. Wang, Table of Radionuclides 2013 (Bureau International des Poids et Mesures: France).

[131]  J. D. G. Correia, A. Paulo, P. D. Raposinho, I. Santos, Dalton Trans. 2011, 40, 6144.
         | Crossref | GoogleScholarGoogle Scholar |

[132]  K. P. Zhernosekov, D. V. Filosofov, R. P. Baum, P. Aschoff, H. Bihl, A. A. Razbash, M. Jahn, M. Jennewein, F. Rösch, J. Nucl. Med. 2007, 48, 1741.
         | Crossref | GoogleScholarGoogle Scholar | 17873136PubMed |

[133]  M. K. Pandey, J. F. Byrne, H. Jiang, A. B. Packard, T. R. DeGrado, Am. J. Nucl. Med. Mol. Imaging 2014, 4, 303.
         | 24982816PubMed |

[134]  M. Sadeghi, T. Kakavand, S. Rajabifar, L. Mokhtari, A. Rahimi-Nezhad, Nukleonika 2009, 54, 25.

[135]  M. K. Pandey, J. F. Byrne, K. N. Schlasner, N. R. Schmit, T. R. DeGrado, Nucl. Med. Biol. 2019, 74–75, 49.
         | Crossref | GoogleScholarGoogle Scholar | 31085059PubMed |

[136]  M. Nair, S. Happel, T. Eriksson, M. K. Pandey, T. R. DeGrado, K. Gagnon, Eur. J. Nucl. Med. Mol. Imaging 2017, 44, S275.

[137]  S. Riga, G. Cicoria, D. Pancaldi, F. Zagni, S. Vichi, M. Dassenno, L. Mora, F. Lodi, M. P. Morigi, M. Marengo, Phys. Med. 2018, 55, 116.
         | Crossref | GoogleScholarGoogle Scholar | 30473059PubMed |

[138]  M. Lin, G. J. Waligorski, C. G. Lepera, Appl. Radiat. Isot. 2018, 133, 1.
         | Crossref | GoogleScholarGoogle Scholar | 29272820PubMed |

[139]  H. Thisgaard, J. Kumlin, N. Langkjær, J. Chua, B. Hook, M. Jensen, A. Kassaian, S. Zeisler, S. Borjian, M. Cross, P. Schaffer, J. H. Dam, EJNMMI Radiopharm. Chem. 2021, 6, 1.
         | Crossref | GoogleScholarGoogle Scholar | 33411034PubMed |

[140]  S. Eberl, T. Eriksson, O. Svedberg, J. Norling, D. Henderson, P. Lam, M. Fulham, Appl. Radiat. Isot. 2012, 70, 922.
         | Crossref | GoogleScholarGoogle Scholar | 22476015PubMed |

[141]  R. Delgado, V. Félix, L. M. P. Lima, D. W. Price, Dalton Trans. 2007, 2734.
         | Crossref | GoogleScholarGoogle Scholar | 17592589PubMed |

[142]  A. Meents, S. Gutmann, A. Wagner, C. Schulze-Briese, Proc. Natl. Acad. Sci. USA 2010, 107, 1094.
         | Crossref | GoogleScholarGoogle Scholar | 20080548PubMed |

[143]  W. Brand-Williams, M. E. Cuvelier, C. Berset, Lebensm. Wiss. Technol. 1995, 28, 25.
         | Crossref | GoogleScholarGoogle Scholar |

[144]  S. Liu, D. S. Edwards, Bioconjug. Chem. 2001, 12, 554.
         | Crossref | GoogleScholarGoogle Scholar | 11459460PubMed |

[145]  S. Liu, C. E. Ellars, D. S. Edwards, Bioconjug. Chem. 2003, 14, 1052.
         | Crossref | GoogleScholarGoogle Scholar | 13129412PubMed |

[146]  R. Shannon, Acta Crystallogr. A 1976, 32, 751.
         | Crossref | GoogleScholarGoogle Scholar |

[147]  T. J. Wadas, E. H. Wong, G. R. Weisman, C. J. Anderson, Chem. Rev. 2010, 110, 2858.
         | Crossref | GoogleScholarGoogle Scholar | 20415480PubMed |

[148]  W. P. Cacheris, S. K. Nickle, A. D. Sherry, Inorg. Chem. 1987, 26, 958.
         | Crossref | GoogleScholarGoogle Scholar |

[149]  E. T. Clarke, A. E. Martell, Inorg. Chim. Acta 1991, 181, 273.
         | Crossref | GoogleScholarGoogle Scholar |

[150]  E. T. Clarke, A. E. Martell, Inorg. Chim. Acta 1991, 190, 27.
         | Crossref | GoogleScholarGoogle Scholar |

[151]  E. T. Clarke, A. E. Martell, Inorg. Chim. Acta 1991, 190, 37.
         | Crossref | GoogleScholarGoogle Scholar |

[152]  M. Kodama, T. Koike, A. B. Mahatma, E. Kimura, Inorg. Chem. 1991, 30, 1270.
         | Crossref | GoogleScholarGoogle Scholar |

[153]  K. Kumar, C. A. Chang, L. C. Francesconi, D. D. Dischino, M. F. Malley, J. Z. Gougoutas, M. F. Tweedle, Inorg. Chem. 1994, 33, 3567.
         | Crossref | GoogleScholarGoogle Scholar |

[154]  K. Kumar, C. A. Chang, M. F. Tweedle, Inorg. Chem. 1993, 32, 587.
         | Crossref | GoogleScholarGoogle Scholar |

[155]  A. E. Martell, R. J. Motekaitis, E. T. Clarke, R. Delgado, Y. Sun, R. Ma, Supramol. Chem. 1996, 6, 353.
         | Crossref | GoogleScholarGoogle Scholar |

[156]  R. Delgado, Y. Sun, R. J. Motekaitis, A. E. Martell, Inorg. Chem. 1993, 32, 3320.
         | Crossref | GoogleScholarGoogle Scholar |

[157]  I. Velikyan, H. Maecke, B. Langstrom, Bioconjug. Chem. 2008, 19, 569.
         | Crossref | GoogleScholarGoogle Scholar | 18205327PubMed |

[158]  S. Banerjee, M. R. A. Pillai, F. F. Knapp, Chem. Rev. 2015, 115, 2934.
         | Crossref | GoogleScholarGoogle Scholar | 25865818PubMed |

[159]  J. Fichna, A. Janecka, Bioconjug. Chem. 2003, 14, 3.
         | Crossref | GoogleScholarGoogle Scholar | 12526687PubMed |

[160]  T. C. Owen, M. T. Brown, J. Org. Chem. 1969, 34, 1161.
         | Crossref | GoogleScholarGoogle Scholar |

[161]  G. Xu, M. R. Chance, Anal. Chem. 2004, 76, 1213.
         | Crossref | GoogleScholarGoogle Scholar | 14987073PubMed |

[162]  A. H. Snell, Proceedings of the American Physical Society: Physical Review 1937, 51, 142.

[163]  J. F. Volker, H. C. Hodge, H. J. Wilson, S. N. Van Voorhis, J. Biol. Chem. 1940, 134, 543.
         | Crossref | GoogleScholarGoogle Scholar |

[164]  O. Jacobson, D. O. Kiesewetter, X. Chen, Bioconjug. Chem. 2015, 26, 1.
         | Crossref | GoogleScholarGoogle Scholar | 25473848PubMed |

[165]  N. A. Meanwell, J. Med. Chem. 2018, 61, 5822.
         | Crossref | GoogleScholarGoogle Scholar | 29400967PubMed |

[166]  H.-J. Böhm, D. Banner, S. Bendels, M. Kansy, B. Kuhn, K. Müller, U. Obst-Sander, M. Stahl, ChemBioChem 2004, 5, 637.
         | Crossref | GoogleScholarGoogle Scholar | 15122635PubMed |

[167]  R. Haubner, B. Kuhnast, C. Mang, W. A. Weber, H. Kessler, H. J. Wester, M. Schwaiger, Bioconjug. Chem. 2004, 15, 61.
         | Crossref | GoogleScholarGoogle Scholar | 14733584PubMed |

[168]  M. B. Haskali, D. Denoyer, W. Noonan, C. Culinane, C. Rangger, N. Pouliot, R. Haubner, P. D. Roselt, R. J. Hicks, C. A. Hutton, Mol. Pharm. 2017, 14, 1169.
         | Crossref | GoogleScholarGoogle Scholar | 28191977PubMed |

[169]  E. Hess, S. Takács, B. Scholten, F. Tárkányi, H. H. Coenen, S. M. Qaim, Radiochim. Acta 2001, 89, 357.
         | Crossref | GoogleScholarGoogle Scholar |

[170]  H. H. Coenen, in PET Chemistry (Eds P. A. Schubiger, L. Lehmann, M. Friebe) 2007, pp. 15–50 (Springer: Berlin).

[171]  O. Jacobson, X. Chen, Curr. Top. Med. Chem. 2010, 10, 1048.
         | Crossref | GoogleScholarGoogle Scholar | 20388116PubMed |

[172]  E. Hess, G. Blessing, H. H. Coenen, S. M. Qaim, Appl. Radiat. Isot. 2000, 52, 1431.
         | Crossref | GoogleScholarGoogle Scholar | 10855672PubMed |

[173]  C. Hansch, A. Leo, R. W. Taft, Chem. Rev. 1991, 91, 165.
         | Crossref | GoogleScholarGoogle Scholar |

[174]  V. W. Pike, F. I. Aigbirhio, J. Labelled Comp. Radiopharm. 1995, 37, 120.

[175]  W. Qu, X. Li, in Fluorination (Eds J. Hu, T. Umemoto) 2018, pp. 1–12 (Springer: Singapore).

[176]  M. B. Haskali, S. Telu, Y.-S. Lee, C. L. Morse, S. Lu, V. W. Pike, J. Org. Chem. 2016, 81, 297.
         | Crossref | GoogleScholarGoogle Scholar | 26641128PubMed |

[177]  B. H. Rotstein, N. A. Stephenson, N. Vasdev, S. H. Liang, Nat. Commun. 2014, 5, 4365.
         | Crossref | GoogleScholarGoogle Scholar | 25007318PubMed |

[178]  A. V. Mossine, A. F. Brooks, K. J. Makaravage, J. M. Miller, N. Ichiishi, M. S. Sanford, P. J. H. Scott, Org. Lett. 2015, 17, 5780.
         | Crossref | GoogleScholarGoogle Scholar | 26568457PubMed |

[179]  J. S. Wright, T. Kaur, S. Preshlock, S. S. Tanzey, W. P. Winton, L. S. Sharninghausen, N. Wiesner, A. F. Brooks, M. S. Sanford, P. J. H. Scott, Clin. Transl. Imaging 2020, 8, 167.
         | Crossref | GoogleScholarGoogle Scholar | 33748018PubMed |

[180]  K. J. Makaravage, A. F. Brooks, A. V. Mossine, M. S. Sanford, P. J. H. Scott, Org. Lett. 2016, 18, 5440.
         | Crossref | GoogleScholarGoogle Scholar | 27718581PubMed |

[181]  S. Preshlock, S. Calderwood, S. Verhoog, M. Tredwell, M. Huiban, A. Hienzsch, S. Gruber, T. C. Wilson, N. J. Taylor, T. Cailly, M. Schedler, T. L. Collier, J. Passchier, R. Smits, J. Mollitor, A. Hoepping, M. Mueller, C. Genicot, J. Mercier, V. Gouverneur, Chem. Commun. 2016, 52, 8361.
         | Crossref | GoogleScholarGoogle Scholar |

[182]  D. G. Hall, in Boronic Acids (Eds D. G. Hall) 2011, pp. 1–133 (Wiley-VCH: Weinheim, Germany).

[183]  H. J. Wester, M. Schottelius, in PET Chemistry (Eds P. A. Schubiger, L. Lehmann, M. Friebe) 2007, pp. 79–111 (Springer: Berlin).

[184]  K. A. Jacobson, D. C. Furlano, K. L. Kirk, J. Fluor. Chem. 1988, 39, 339.
         | Crossref | GoogleScholarGoogle Scholar | 26523070PubMed |

[185]  H. S. Krishnan, L. Ma, N. Vasdev, S. H. Liang, Chem. – Eur. J. 2017, 23, 15553.
         | Crossref | GoogleScholarGoogle Scholar | 28704575PubMed |

[186]  S. Guhlke, H. H. Coenen, G. Stöcklin, Appl. Radiat. Isot. 1994, 45, 715.
         | Crossref | GoogleScholarGoogle Scholar |

[187]  H. J. Wester, K. Hamacher, G. Stöcklin, Nucl. Med. Biol. 1996, 23, 365.
         | Crossref | GoogleScholarGoogle Scholar | 8782249PubMed |

[188]  D. E. Olberg, J. M. Arukwe, D. Grace, O. K. Hjelstuen, M. Solbakken, G. M. Kindberg, A. Cuthbertson, J. Med. Chem. 2010, 53, 1732.
         | Crossref | GoogleScholarGoogle Scholar | 20088512PubMed |

[189]  M. Schlosser, R. Ruzziconi, Synthesis 2010, 2010, 2111.
         | Crossref | GoogleScholarGoogle Scholar |

[190]  M. B. Haskali, P. D. Roselt, J. A. Karas, W. Noonan, C. W. Wichmann, A. Katsifis, R. J. Hicks, C. A. Hutton, J. Labelled Comp. Radiopharm. 2013, 56, 726.
         | Crossref | GoogleScholarGoogle Scholar | 24339012PubMed |

[191]  M. B. Haskali, A. L. Farnsworth, P. D. Roselt, C. A. Hutton, RSC Med. Chem. 2020, 11, 919.
         | Crossref | GoogleScholarGoogle Scholar | 33479687PubMed |

[192]  M. B. Haskali, P. D. Roselt, R. J. Hicks, C. A. Hutton, J. Labelled Comp. Radiopharm. 2018, 61, 61.
         | Crossref | GoogleScholarGoogle Scholar | 29143364PubMed |

[193]  J. Cardinale, R. Martin, Y. Remde, M. Schäfer, A. Hienzsch, S. Hübner, A. M. Zerges, H. Marx, R. Hesse, K. Weber, R. Smits, A. Hoepping, M. Müller, O. C. Neels, K. Kopka, Pharmaceuticals (Basel) 2017, 10, 77.
         | Crossref | GoogleScholarGoogle Scholar |

[194]  S. Naka, T. Watabe, K. Kurimoto, M. Uemura, F. Soeda, O. C. Neels, K. Kopka, M. Tatsumi, H. Kato, N. Nonomura, E. Shimosegawa, J. Cardinale, F. L. Giesel, J. Hatazawa, EJNMMI Radiopharm. Chem. 2020, 5, 18.
         | Crossref | GoogleScholarGoogle Scholar | 32728815PubMed |

[195]  M. H. Dornan, J.-M. Simard, A. Leblond, D. Juneau, G. Delouya, F. Saad, C. Ménard, J. N. DaSilva, J. Labelled Comp. Radiopharm. 2018, 61, 757.
         | Crossref | GoogleScholarGoogle Scholar |

[196]  M. Richard, S. Specklin, M. Roche, F. Hinnen, B. Kuhnast, Chem. Commun. 2020, 56, 2507.
         | Crossref | GoogleScholarGoogle Scholar |