A Red-Emissive AIE Probe for Targeting Mitochondria in Living Cells
Lufei Xiao
A D , Rui Xiao C , Bingsong Xu B , Hao Chen B and Hui Wang B D
A School of Food and Environmental Engineering, Chuzhou Polytechnic, Chuzhou 239000, China.
B Department of Chemistry, Wannan Medical College, Wuhu 241002, China.
C School of Mechanical Engineering, Taiyuan University of Science and Technology, Taiyuan 030024, China.
D Corresponding authors. Email: xiaolufei@chzc.edu.cn; wanghias@126.com
Australian Journal of Chemistry 74(2) 151-156 https://doi.org/10.1071/CH20122
Submitted: 16 April 2020 Accepted: 21 June 2020 Published: 10 July 2020
Abstract
A novel compound has been synthesised and characterised by various spectroscopic techniques. Analysing the crystal structures of the compound shows that multiple molecular interactions exist. The compound exhibits distinct aggregation-induced emission activity in EtOH/H2O accompanying a 2-fold enhancement of fluorescence intensity at ~609 nm. In addition, the cytotoxicity assay and confocal microscopy imaging show that the compound is hypotoxic and can be used as a fluorescent labelling dye in the near-infrared region to track mitochondria in living cells.
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