Improved Fenton Therapy Using Cancer Cell Hydrogen Peroxide*

Hadi Ranji-Burachaloo; Qiang Fu; Paul A. Gurr; Dave E. Dunstan; Greg G. Qiao

doi:10.1071/CH18281

RESEARCH ARTICLE

Previous Contents Vol 71(10)

Improved Fenton Therapy Using Cancer Cell Hydrogen Peroxide*

Hadi Ranji-Burachaloo

^A ^B , Qiang Fu

^A , Paul A. Gurr

^A , Dave E. Dunstan

^B ^C and Greg G. Qiao

^A ^C

+ Author Affiliations

- Author Affiliations

^A Polymer Science Group, Department of Chemical Engineering, The University of Melbourne, Parkville, Vic. 3010, Australia.

^B Complex Fluids Group, Department of Chemical Engineering, The University of Melbourne, Parkville, Vic. 3010, Australia.

^C Corresponding authors. Email: davided@unimelb.edu.au; gregghq@unimelb.edu.au

Australian Journal of Chemistry 71(10) 826-836 https://doi.org/10.1071/CH18281
Submitted: 7 June 2018 Accepted: 18 August 2018 Published: 19 September 2018

Abstract

Fenton cancer therapy as a new methodology for the treatment of tumour cells is largely restricted owing to the low stability, high aggregation, and poor selectivity of reported nanoparticles. In this study, an improved approach for the selective destruction of cancer cells is reported. Metal–organic framework (MOF) nanoparticles were synthesized and reduced via a hydrothermal method, and then PEGylated through the surface-initiated atom transfer radical polymerization (SI-ATRP) reaction to produce a PEGylated reduced MOF (P@rMOF). The ratio of PEG to nanoparticles was used to optimize the size and aggregation of the nanoparticles, with 2P@rMOF (2 : 1 mass ratio) having the smallest hydrodynamic diameter. The nanoparticles were further conjugated with folic acid for cell targeting. In vitro cell uptake experiments demonstrated that the internalization of 2P@rMOF-FA nanoparticles into cancer cells (HeLa) was almost 3-fold that of normal cells (NIH-3T3). In the presence of 2P@rMOF-FA, the HeLa cell viability decreased dramatically to 22 %, whereas the NIH-3T3 cell viability remained higher than 80 % after 24 h incubation. The selectivity index for 2P@rMOF-FA is 4.48, which is significantly higher than those reported in the literature for similar strategies. This work thus demonstrates the most stable and selective nanoparticle system for the treatment of cancer cells using the cell’s own H₂O₂.

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