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RESEARCH ARTICLE
Contents Vol 70(3)

Synthesis and Evaluation of a Biocompatible Macromolecular Gadolinium Compound as a Liver-Specific Contrast Agent for MRI

Youyang Zhan A B , Rong Xue A , Mengchao Zhang C , Chuanling Wan A B , Xiaojing Li A D , Fengkui Pei A , Changjiang Sun C and Lin Liu C
+ Author Affiliations
- Author Affiliations

A Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

B University of Chinese Academy of Sciences, Beijing 100049, China.

C China-Japan Union Hospital, Jilin University, Changchun 130033, China.

D Corresponding author. Email: xjli@ciac.ac.cn

Australian Journal of Chemistry 70(3) 307-313 https://doi.org/10.1071/CH16347
Submitted: 7 June 2016  Accepted: 1 September 2016   Published: 26 October 2016

Abstract

A new macromolecular biocompatible gadolinium chelate complex (PAI-N2-DOTA-Gd) as a liver-specific magnetic resonance imaging (MRI) contrast agent was synthesised and evaluated. An aspartic acid–isoleucine copolymer was chemically linked with Gd-DOTA via ethylenediamine to give PAI-N2-DOTA-Gd. In vitro, the T1-relaxivity of PAI-N2-DOTA-Gd (14.38 mmol–1Ls–1, 0.5 T) was much higher than that of the clinically used Gd-DOTA (4.96 mmol–1Ls–1, 0.5 T), with obvious imaging signal enhancement. In the imaging experiments in vivo, PAI-N2-DOTA-Gd exhibited good liver selectivity, and had a greater intensity enhancement (68.8 ± 5.6 %) and a longer imaging window time (30–70 min), compared to Gd-DOTA (21.1 ± 5.3 %, 10–30 min). Furthermore, the in vivo histological studies of PAI-N2-DOTA-Gd showed a low acute toxicity and desirable biocompatibility. The results of this study indicate that PAI-N2-DOTA-Gd is a feasible liver-specific contrast agent for MRI.


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