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Contents Vol 68(9)

3D-Printable Biodegradable Polyester Tissue Scaffolds for Cell Adhesion

Justin M. Sirrine A , Allison M. Pekkanen B , Ashley M. Nelson A , Nicholas A. Chartrain C , Christopher B. Williams D and Timothy E. Long A B E
+ Author Affiliations
- Author Affiliations

A Department of Chemistry, Macromolecules and Interfaces Institute, Virginia Tech, Blacksburg, VA 24061, USA.

B School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24061, USA.

C Department of Materials Science and Engineering, Virginia Tech, Blacksburg, VA 24061, USA.

D Department of Mechanical Engineering, Virginia Tech, Blacksburg, VA 24061, USA.

E Corresponding author. Email: telong@vt.edu

Australian Journal of Chemistry 68(9) 1409-1414 https://doi.org/10.1071/CH15327
Submitted: 6 June 2015  Accepted: 7 July 2015   Published: 4 August 2015

Abstract

Additive manufacturing, or three-dimensional (3D) printing, has emerged as a viable technique for the production of vascularized tissue engineering scaffolds. In this report, a biocompatible and biodegradable poly(tri(ethylene glycol) adipate) dimethacrylate was synthesized and characterized for suitability in soft-tissue scaffolding applications. The polyester dimethacrylate exhibited highly efficient photocuring, hydrolyzability, and 3D printability in a custom microstereolithography system. The photocured polyester film demonstrated significantly improved cell attachment and viability as compared with controls. These results indicate promise of novel, printable polyesters for 3D patterned, vascularized soft-tissue engineering scaffolds.


References

[1]  K. Arcaute, B. Mann, R. Wicker, Acta Biomater. 2010, 6, 1047.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXjtlClurg%3D&md5=f89f798b877be8de8de0f67a79d0ae9aCAS | 19683602PubMed |

[2]  F. P. W. Melchels, J. Feijen, D. W. Grijpma, Biomaterials 2010, 31, 6121.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXnt12rt7k%3D&md5=4f9ac32ac58d755fdd7e81d40772ecadCAS |

[3]  F. P. W. Melchels, J. Feijen, D. W. Grijpma, Biomaterials 2009, 30, 3801.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXmvVyksb8%3D&md5=afb61b0898806d5fa55b03644eb00a41CAS |

[4]  A. A. Makitie, J. Korpela, L. Elomaa, M. Reivonen, A. Kokkari, M. Malin, H. Korhonen, X. Wang, J. Salo, E. Sihvo, M. Salmi, J. Partanen, K.-S. Paloheimo, J. Tuomi, T. Närhi, J. Seppälä, Acta Otolaryngol. 2013, 133, 412.
         | Crossref | GoogleScholarGoogle Scholar | 23394221PubMed |

[5]  D. Barrett, M. Yousaf, Molecules 2009, 14, 4022.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXht12lsrnO&md5=8d3886480eac81e14956141124844d5bCAS | 19924045PubMed |

[6]  D. Puppi, C. Mota, M. Gazzarri, D. Dinucci, A. Gloria, M. Myrzabekova, L. Ambrosio, F. Chiellini, Biomed. Microdevices 2012, 14, 1115.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhslKhtr3O&md5=c56b4e49e0b12e8a914b3bb531261b9eCAS | 22767245PubMed |

[7]  L. E. Freed, G. Vunjak-Novakovic, R. J. Biron, D. B. Eagles, D. C. Lesnoy, S. K. Barlow, R Langer, Nat. Biotechnol. 1994, 12, 689.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2cXkvFWksb4%3D&md5=aaa77c6f7177cee17367cd30185d5cdcCAS |

[8]  B. Tian, J. Liu, T. Dvir, L. Jin, J. H. Tsui, Q. Qing, Z Suo, R Langer, D. S. Kohane, C. M. Lieber, Nat. Mater. 2012, 11, 986.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38Xht1GhtrzL&md5=56a3dcb3342215202f882e28ff51e35aCAS | 22922448PubMed |

[9]  T. P. Kraehenbuehl, R. Langer, L. S. Ferreira, Nat. Methods 2011, 8, 731.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtV2gtL3L&md5=16af310bd8f9a78683a87d957e9c21a9CAS | 21878920PubMed |

[10]  T. Dvir, B. P. Timko, D. S. Kohane, R. Langer, Nat. Nanotechnol. 2011, 6, 13.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhs1Wju73E&md5=38787054211aa90e77583908cdcc48f6CAS | 21151110PubMed |

[11]  A. M. Kloxin, A. M. Kasko, C. N. Salinas, K. S. Anseth, Science 2009, 324, 59.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXjvVajsL4%3D&md5=9ff76fdc0545d383bf2adb86f124d070CAS | 19342581PubMed |

[12]  E. S. Place, J. H. George, C. K. Williams, M. M. Stevens, Chem. Soc. Rev. 2009, 38, 1139.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXjsFaisr0%3D&md5=5898e80282f65fd7db3bd44fc963f00cCAS | 19421585PubMed |

[13]  R. G. Wylie, S. Ahsan, Y. Aizawa, K. L. Maxwell, C. M. Morshead, M. S. Shoichet, Nat. Mater. 2011, 10, 799.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtVylurrI&md5=120da65331b1a20d91982a84b6c96fdaCAS | 21874004PubMed |

[14]  M. Vaezi, H. Seitz, S. Yang, Int. J. Adv. Manuf. Technol. 2013, 67, 1721.
         | Crossref | GoogleScholarGoogle Scholar |

[15]  J. P. Kruth, M. C. Leu, T. Nakagawa, CIRP Ann. – Manuf. Technol. 1998, 47, 525.
         | Crossref | GoogleScholarGoogle Scholar |

[16]  A. R. Schultz, P. M. Lambert, N. A. Chartrain, D. M. Ruohoniemi, Z. Zhang, C. Jangu, M Zhang, C. B. Williams, T. E. Long, ACS Macro Lett. 2014, 3, 1205.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXhvVyhtbbK&md5=bfb19c1bccafac684a8dec5806f35e05CAS |

[17]  S. Skoog, P. Goering, R. Narayan, J. Mater. Sci. Mater. Med. 2014, 25, 845.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXhvFWrtbrI&md5=d77a750e7f6eff7dcafd577fa7865cb1CAS | 24306145PubMed |

[18]  A. Ronca, L. Ambrosio, D. W. Grijpma, Acta Biomater. 2013, 9, 5989.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXnslCisQ%3D%3D&md5=ee3ac46e0e20c0512bfd5092e3fa0bc4CAS | 23232210PubMed |

[19]  R. Gauvin, Y.-C. Chen, J. W. Lee, P. Soman, P. Zorlutuna, J. W. Nichol, H Bae, S. Chen, A. Khademhosseini, Biomaterials 2012, 33, 3824.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XivFWru7c%3D&md5=35f8c21e4471649fc6dce4648564bda9CAS | 22365811PubMed |

[20]  D. W. Hutmacher, T. Schantz, I. Zein, K. W. Ng, S. H. Teoh, K. C. Tan, J. Biomed. Mater. Res. 2001, 55, 203.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXhs1Omtr4%3D&md5=9ae57947720d965eebaeb8931dc7aaf8CAS | 11255172PubMed |

[21]  I. Zein, D. W. Hutmacher, K. C. Tan, S. H. Teoh, Biomaterials 2002, 23, 1169.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXos1WqtLY%3D&md5=98b21fc05fa564fef30d234464360398CAS | 11791921PubMed |

[22]  J. Korpela, A. Kokkari, H. Korhonen, M. Malin, T. Närhi, J. Seppälä, J. Biomed. Mater. Res. Part B 2013, 101B, 610.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXlsVCqs7g%3D&md5=3c0ce477a824b5382782ec5f7d757f94CAS |

[23]  T. Niino, D. Hamajima, K. Montagne, S. Oizumi, H. Naruke, H. Huang, Y. Sakai, H. Kinoshita, T. Fujii, Biofabrication 2011, 3, 034104.
         | Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3Mfkt1agsQ%3D%3D&md5=6adca6aff9f2318fdd2095aa80e84c3bCAS | 21725146PubMed |

[24]  Y. Zhang, L. Hao, M. M. Savalani, R. A. Harris, L. Di Silvio, K. E. Tanner, J. Biomed. Mater. Res. Part A 2009, 91A, 1018.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhtl2rtrzF&md5=9655a898437f9a4c429a8f30100a1efbCAS |

[25]  K.-C. Hung, C.-S. Tseng, S.-h. Hsu, Adv. Healthcare Mater. 2014, 3, 1578.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXhslajs7nE&md5=7421f306e4baa3047143478ea84ce0ceCAS |

[26]  S. G. Wetzel, M. Ohta, A. Handa, J.-M. Auer, P. Lylyk, K.-O. Lovblad, D Babic, D. A. Rufenacht, AJNR Am. J. Neuroradiol. 2005, 26, 1425.
         | 15956510PubMed |

[27]  J. R. Tumbleston, D. Shirvanyants, N. Ermoshkin, R. Janusziewicz, A. R. Johnson, D. Kelly, K Chen, R. Pinschmidt, J. P. Rolland, A. Ermoshkin, E. T. Samulski, J. M. DeSimone, Science 2015, 347, 1349.
         | 1:CAS:528:DC%2BC2MXksVOqu7g%3D&md5=6e4ce363de631d9d24f3ad3ce5dab181CAS | 25780246PubMed |

[28]  F. Brandi, F. Anjum, L. Ceseracciu, A. C. Barone, A. Athanassiou, J. Micromech. Microeng. 2011, 21, 054007.
         | Crossref | GoogleScholarGoogle Scholar |

[29]  M. M. Savalani, R. A. Harris, Proc. Inst. Mech. Eng. Part H 2006, 220, 505.
         | Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD28zptV2jsg%3D%3D&md5=40a08d682a76135203d47ed8e8e4a338CAS |

[30]  T. I. Croll, A. J. O’Connor, G. W. Stevens, J. J. Cooper-White, Biomacromolecules 2004, 5, 463.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXhvVehs7g%3D&md5=edde36634d20e84800e7920175470bbcCAS | 15003007PubMed |

[31]  L. Cai, S. Wang, Polymer 2010, 51, 164.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhs1SqsrrF&md5=0314fb61d3cb211d7a653ea907aed342CAS |

[32]  T. Matsuda, M. Mizutani, J. Biomed. Mater. Res. 2002, 62, 395.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XntFOkur0%3D&md5=6da39f26cbf6c71a163d5a2088d15d13CAS | 12209925PubMed |

[33]  T. M. Seck, F. P. W. Melchels, J. Feijen, D. W. Grijpma, J. Control. Release 2010, 148, 34.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhsVCmsbzP&md5=c2131f2485c0535c18bd8d18546d4fa9CAS | 20659509PubMed |

[34]  E. P. Childers, M. O. Wang, M. L. Becker, J. P. Fisher, D. Dean, MRS Bull. 2015, 40, 119.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2MXis1agsL8%3D&md5=e42d5b6303c52d6857da504400d31ef7CAS |

[35]  J. W. Lee, K. S. Kang, S. H. Lee, J.-Y. Kim, B.-K. Lee, D.-W. Cho, Biomaterials 2011, 32, 744.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhsVCnurbI&md5=50202f492e690de95786ec378b1aadddCAS | 20933279PubMed |

[36]  L. Cai, K. Wang, S. Wang, Biomaterials 2010, 31, 4457.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXjvFSrsrY%3D&md5=37bcb23a8621b27bfdf5f9baa28fd311CAS | 20202682PubMed |

[37]  S. Sharifi, S. B. G. Blanquer, T. G. van Kooten, D. W. Grijpma, Acta Biomater. 2012, 8, 4233.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38Xhs1GktLrE&md5=8596beda3ff3404dcd60cdb17b43da21CAS | 22995403PubMed |

[38]  S. Schüller-Ravoo, S. M. Teixeira, J. Feijen, D. W. Grijpma, A. A. Poot, Macromol. Biosci. 2013, 13, 1711.
         | Crossref | GoogleScholarGoogle Scholar | 24214105PubMed |

[39]  B. L. Dargaville, C. Vaquette, H. Peng, F. Rasoul, Y. Q. Chau, J. J. Cooper-White, J. H. Campbell, A. K. Whittaker, Biomacromolecules 2011, 12, 3856.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtlOgu7zE&md5=e46d79eb3753022214638dc184a3c771CAS | 21999900PubMed |

[40]  G. L. Kennedy, Drug Chem. Toxicol. 2002, 25, 191.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XjslSitrY%3D&md5=fedfa3a6e4d46630bff62472eeed75bbCAS | 12024802PubMed |

[41]  G. Mingrone, M. Castagneto, Nutr. Rev. 2006, 64, 449.
         | Crossref | GoogleScholarGoogle Scholar | 17063926PubMed |

[42]  S. W. Borron, F. J. Baud, R. Garnier, Vet. Hum. Toxicol. 1997, 39, 26.
         | 1:STN:280:DyaK2s7lvVWqsw%3D%3D&md5=25999bfbb594e42f9c006ad43c0d0773CAS | 9004463PubMed |

[43]  W. Mormann, U. Michel, Carbohydr. Polym. 2002, 50, 201.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38Xksl2gtL4%3D&md5=ddf566c936cbff1b004a035935f64cefCAS |

[44]  B. Luan, X. Y. Liu, J. Nagata, W.-J. Cheong, Surf. Coat. Tech. 2005, 192, 323.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXkt1yr&md5=e1a821c8c4641f6d298ba0057a4c7779CAS |

[45]  P. M. Lambert, Design and Fabrication of a Mask Projection Microstereolithography System for the Characterization and Processing of Novel Photopolymer Resins 2014 (Virginia Tech: Blacksburg, VA).

[46]  J.-H. Cho, T. James, D. H. Gracias, Adv. Mater. 2010, 22, 2320.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXntVyjtbo%3D&md5=e70fdd84803635a8b2204a0bcc75b86cCAS | 20376856PubMed |

[47]  T. G. Leong, C. L. Randall, B. R. Benson, N. Bassik, G. M. Stern, D. H. Gracias, Proc. Natl. Acad. Sci. USA 2009, 106, 703.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXht12jurY%3D&md5=055f35d205181e2ea820acad852f13adCAS | 19139411PubMed |

[48]  N. Bassik, G. M. Stern, D. H. Gracias, Appl. Phys. Lett. 2009, 95, 091901.
         | Crossref | GoogleScholarGoogle Scholar |

[49]  N. Bassik, G. M. Stern, M. Jamal, D. H. Gracias, Adv. Mater. 2008, 20, 4760.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXns1Cntg%3D%3D&md5=d15326d0a58e8129bfc8f10c70328fabCAS |

[50]  E. C. Novosel, C. Kleinhans, P. J. Kluger, Adv. Drug Deliv. Rev. 2011, 63, 300.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXntV2ntrc%3D&md5=2c371f0db8725b8cf1317326a9540cfdCAS | 21396416PubMed |

[51]  C. Xu, F. Yang, S. Wang, S. Ramakrishna, J. Biomed. Mater. Res. Part A 2004, 71A, 154.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXnvVWlur0%3D&md5=e54a75d7fbac392f426a2455fc284118CAS |

[52]  Y.-C. Liao, Y.-T. Ma, C.-H. Huang, J. Yu, H.-M. Hsiao, ACS Appl. Mater. Interfaces 2012, 4, 3335.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XptF2gs7c%3D&md5=c2f3e26159f3e7c42c11c368d74746f4CAS | 22732105PubMed |

[53]  G. Odian, Principles of Polymerization, 4th edn 2004 (Wiley: New York, NY).