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RESEARCH FRONT
Contents Vol 68(3)

Synthesis, Characterisation, and Antifungal Activities of Novel Benzodiazaborines*

Jiyoung Yang A , Brandon J. Johnson A , Allan A. Letourneau B , Christopher M. Vogels A , Andreas Decken C D , Felix J. Baerlocher B D and Stephen A. Westcott A D
+ Author Affiliations
- Author Affiliations

A Department of Chemistry and Biochemistry, Mount Allison University, Sackville, NB E4L 1G8, Canada.

B Department of Biology, Mount Allison University, Sackville, NB E4L 1G7, Canada.

C Department of Chemistry, University of New Brunswick, Fredericton, NB E3B 5A3, Canada.

D Corresponding authors. Email: swestcott@mta.ca; adecken@unb.ca (X-ray studies); fbaerlocher@mta.ca (antifungal studies).

Australian Journal of Chemistry 68(3) 366-372 https://doi.org/10.1071/CH14534
Submitted: 31 August 2014  Accepted: 29 September 2014   Published: 15 December 2014

Abstract

Eight new fluoro- and methoxy-substituted benzodiazaborines have been prepared by a simple condensation reaction in high-to-excellent yields. All new compounds have been characterised by several physical methods, including X-ray diffraction studies on three examples. All new compounds were examined for antifungal activities against five species of potentially pathogenic fungi (Aspergillus niger, Aspergillus fumigatus, Rhizoctonia solani, Verticillium albo-atrum, and Verticillium dahliae). While substitution of the aromatic group derived from the 2-formylphenylboronic acid group had an effect on bioactivities, substitution on the parent thioamide C(=S)NH2 group of the starting thiosemicarbazide greatly reduced activities.


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