Kinetic Studies on the Reactions of [(TLtBu)PtCl]+ and [Pt(tpdm)Cl]+ Complexes with Some Thiols and Thioethers
Enisa Selimović A , Biljana Petrović A , Dragan Čanović B , Živadin D. Bugarčić A and Jovana Bogojeski A CA Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovića 12, PO Box 60, 34000 Kragujevac, Serbia.
B Faculty of Medicine, University of Kragujevac, S. Markovića 69, 34000 Kragujevac, Serbia.
C Corresponding author. Email: jrosic@kg.ac.rs
Australian Journal of Chemistry 66(5) 534-538 https://doi.org/10.1071/CH12218
Submitted: 25 April 2012 Accepted: 13 December 2012 Published: 31 January 2013
Abstract
Substitution reactions of the complexes [(TLtBu)PtCl]+ and [Pt(tpdm)Cl]+, where TLtBu = 2,6-bis[(1,3-di-tert-butylimidazolin-2-imino)methyl]pyridine and tpdm = terpyridinedimethane, with nucleophiles: S-methyl-L-cysteine (S-Met-L-Cys), L-cysteine (L-Cys), glutathione (GSH) and L-methionine (L-Met) were studied in aqueous 0.1 M NaClO4 solution in the presence of 10 mM NaCl using variable-temperature UV-vis spectrophotometry. The higher reactivity of the complex with the tpdm ligand could be attributed to the influence of the bulkiness of the tert-butyl-groups from the [(TLtBu)PtCl]+ complex. The order of reactivity of the studied ligands is: S-Met-L-Cys > L-Met > GSH > L-Cys. The thioethers (S-Met-L-Cys and L-Met) are more reactive than the thiols (GSH and L-Cys). This order of reactivity is in relation with their electron properties and structures. The negative values reported for the entropy of activation confirmed the associative mode.
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