Telomerase Inhibition Studies of Novel Spiroketal-Containing Rubromycin Derivatives
Tsz-Ying Yuen A , Yu-Pong Ng B , Fanny C. F. Ip B , Jack L.-Y. Chen A , Darcy J. Atkinson A , Jonathan Sperry A , Nancy Y. Ip B C and Margaret A. Brimble A C
+ Author Affiliations
- Author Affiliations
A School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand.
B Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
C Corresponding authors. Email: boip@ust.hk; m.brimble@auckland.ac.nz
Australian Journal of Chemistry 66(5) 530-533 https://doi.org/10.1071/CH13035
Submitted: 19 January 2013 Accepted: 22 February 2013 Published: 4 March 2013
Abstract
Twenty nine novel spiroketal derivatives related to the rubromycins were evaluated for their anti-telomerase activity using the real-time quantitative telomeric repeat amplification protocol assay. The parent compound γ-rubromycin exhibited the highest potency against human telomerase activity within the series. Modification of the spiroketal motif by the introduction of heteroatoms and substituents at different positions produced analogues with varying bioactivity. Variation at the isocoumarin subunit of the title compound resulted in weaker activity, indicative of its importance in telomerase inhibition.
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