Register      Login
Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
Shopping Cart: ( empty )
You are here: Home > Journals > CH > CH11360
RESEARCH ARTICLE
Contents Vol 65(1)

Encapsulation of Superparamagnetic Iron Oxide Nanoparticles by the Supercritical Antisolvent Process

Un Teng Lam A , Roshan Yoganathan A , Adam G. Carr A , Raffaella Mammucari A and Neil R. Foster A B
+ Author Affiliations
- Author Affiliations

A School of Chemical Engineering, The University of New South Wales, Sydney, NSW 2052, Australia.

B Corresponding author. Email: n.foster@unsw.edu.au

Australian Journal of Chemistry 65(1) 40-44 https://doi.org/10.1071/CH11360
Submitted: 6 September 2011  Accepted: 6 October 2011   Published: 27 October 2011

Abstract

The aim of the experiments in this research was to produce a coated superparamagnetic iron oxide nanoparticle (SPION) product that may be used as a contrasting agent for MRI. There are several methods that can be employed to coat SPIONs. However, many of the current methods employ toxic organic solvents which can be difficult to remove from the product solution. The encapsulation and characterization of SPIONs in Eudragit was done using a supercritical antisolvent system (SAS) with ethanol as the solvent and supercritical carbon dioxide (SC-CO2) as the antisolvent. Particles of diameters less than 200 nm were produced which had preserved superparamagnetic properties. An encapsulation efficiency of 70 % was achieved.


References

[1]  A. K. Fahlvik, J. Klaveness, D. D. Stark, J. Magn. Reson. Imaging 1993, 3, 187.
         | Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK3s7ltlWisA%3D%3D&md5=41d746d508055ad740e27a3e44cdcb3eCAS |

[2]  T. Neuberger, B. Schopf, H. Hofmann, M. Hofmann, B. von Rechenberg, J. Magn. Magn. Mater. 2005, 293, 483.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXktVagsbo%3D&md5=9feb9c19084ae31bf0a620400af3d1f5CAS |

[3]  L. Babes, B. Denizot, G. Tanguy, J. J. Le Jeune, P. Jallet, J. Colloid Interface Sci. 1999, 212, 474.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1MXhvF2js7o%3D&md5=099afd84c334d2bfea8810fe9ca22891CAS |

[4]  A. K. Gupta, M. Gupta, Biomaterials 2005, 26, 3995.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXisFWr&md5=b8d8c4d5bd2dd2afb604eed1cd2f9f3bCAS |

[5]  A. Ferreira, A. A. O. Carneiro, E. R. Moraes, R. B. Oliveira, O. Baffa, J. Magn. Magn. Mater. 2004, 283, 16.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXot1Ortbw%3D&md5=0869bf1f9df1a79a65eb8e614b5a6639CAS |

[6]  T. Cordova-Fraga, J. J. Bernal-Alvarado, G. Gutierrez-Juarez, M. Sosa, M. Vargas-Luna, Physiol. Meas. 2004, 25, 1261.
         | Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD2crmtlemtg%3D%3D&md5=c37c6d501dca1bddbe711b835da319c1CAS |

[7]  A. E. Chastukhin, A. D. Izotov, I. G. Gorichev, A. M. Kutepov, Theor. Found. Chem. Eng. 2003, 37, 398.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXmtVCntb8%3D&md5=ee7536361ecaf5953f5c88b65274c0d9CAS |

[8]  A. K. A. Silva, E. L. da Silva, E. E. Oliveira, J. T. Nagashima, L. A. L. Soares, A. C. Medeiros, J. H. Araujo, I. B. Araujo, A. S. Carrico, E. S. T. Egito, Int. J. Pharm. 2007, 334, 42.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXjtVant78%3D&md5=2d733940c57e067e3003bccca258c2ecCAS |

[9]  P. Chattopadhyay, R. B. Gupta, Ind. Eng. Chem. Res. 2002, 41, 6049.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XotFSqtL4%3D&md5=f68e67be0a410019abccffa10cdb0fabCAS |

[10]  J. Ren, X. Teng, P. Zhang, Method for Preparing Drug-carrying Magnetic Polymer Particle by Using Supercritical CO2 Anti-solvent Process, in European Patent Office, E.P. Office, Editor. 2005: China.

[11]  R. M. Cornell, U. Schwertmann, The Iron Oxides: Structure, Properties, Reactions, Occurrences, and Uses, 2nd ed., 2003 (Wiley-VCH: Weinheim).

[12]  P. Tartaj, M. D. Morales, S. Veintemillas-Verdaguer, T. Gonzalez-Carreno, C. J. Serna, J. Phys. D: Appl. Phys. 2003, 36, R182.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXlvVChs7w%3D&md5=89dc146ba8f9de8a0e562ed396b51935CAS |

[13]  M. Mahmoudi, A. Simchi, M. Imani, A. S. Milani, P. Stroeve, J. Phys. Chem. B 2008, 112, 14470.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhtValu73P&md5=60d3cd65653055d39a7f7e0e72b56cc7CAS |

[14]  D. X. Chen, A. Sanchez, E. Taboada, A. Roig, N. Sun, H. C. Gu, J. Appl. Phys 2009, 105, p. art. no. 083924.