Synchrotron Radiation Spectroscopic Techniques as Tools for the Medicinal Chemist: Microprobe X-Ray Fluorescence Imaging, X-Ray Absorption Spectroscopy, and Infrared Microspectroscopy
Carolyn Therese Dillon
+ Author Affiliations
- Author Affiliations
Centre for Medicinal Chemistry, School of Chemistry, University of Wollongong, NSW 2522, Australia. Email: carolynd@uow.edu.au
Dr Carolyn Dillon is a senior lecturer in the School of Chemistry at the University of Wollongong. Since 1996 she has been using synchrotron radiation techniques for solving inorganic medicinal chemistry problems, at Brookhaven National Laboratory, the Advanced Photon Source, the Australian National Beamline Facility (Tsukuba) and the Australian Synchrotron. |
Australian Journal of Chemistry 65(3) 204-217 https://doi.org/10.1071/CH11287
Submitted: 13 July 2011 Accepted: 24 October 2011 Published: 12 December 2011
Abstract
This review updates the recent advances and applications of three prominent synchrotron radiation techniques, microprobe X-ray fluorescence spectroscopy/imaging, X-ray absorption spectroscopy, and infrared microspectroscopy, and highlights how these tools are useful to the medicinal chemist. A brief description of the principles of the techniques is given with emphasis on the advantages of using synchrotron radiation-based instrumentation rather than instruments using typical laboratory radiation sources. This review focuses on several recent applications of these techniques to solve inorganic medicinal chemistry problems, focusing on studies of cellular uptake, distribution, and biotransformation of established and potential therapeutic agents. The importance of using these synchrotron-based techniques to assist the development of, or validate the chemistry behind, drug design is discussed.
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