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RESEARCH ARTICLE
Contents Vol 62(9)

Site-Specific Cleavage of G-quadruplexes Formed by Oxytricha Telometric Repeats

Magdeline Tao Tao Ng A B , Xinming Li A B , Yifan Wang A , Tianyan Zhou A , Zhaoqi Yang A , Hwee Yun Foo A and Tianhu Li A C
+ Author Affiliations
- Author Affiliations

A Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore.

B These two authors contributed equally to this work.

C Corresponding author. Email: thli@ntu.edu.sg

Australian Journal of Chemistry 62(9) 1189-1193 https://doi.org/10.1071/CH09061
Submitted: 29 January 2009  Accepted: 11 June 2009   Published: 17 September 2009

Abstract

We demonstrate that certain G-quadruplex structures formed by Oxytricha telomeric repeats possess DNA-cleavage ability. Further studies verify that this cleavage activity is both site-specific and G-quadruplex-dependent.


Acknowledgements

The authors wish to express their gratitude to the Ministry of Education of Singapore and Nanyang Technological University for financial support (MOE: T208A1110-TR, MOE2008-T2–1-061 and Tier 1: M52110081) and Dr Martin James Lear and Dr David Yu-Kai Chen for very helpful discussion.


References


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