Biocompatible, Polyampholyte Microgel Particles

Melanie Bradley; Brian Vincent; Gary Burnett

doi:10.1071/CH07098

RESEARCH FRONT

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Biocompatible, Polyampholyte Microgel Particles

Melanie Bradley ^A ^C , Brian Vincent ^A and Gary Burnett ^B

+ Author Affiliations

- Author Affiliations

^A School of Chemistry, University of Bristol, Bristol BS8 1TS, UK.

^B New Products Research (Oral Health Care), GSK, Weybridge KT13 0DE, UK.

^C Corresponding author. Email: melanie.bradley@bristol.ac.uk

Australian Journal of Chemistry 60(9) 646-650 https://doi.org/10.1071/CH07098
Submitted: 7 April 2007 Accepted: 9 July 2007 Published: 11 September 2007

Abstract

Biocompatible, polyampholyte microgel particles have been prepared by the acid hydrolysis of t-butyl groups within (2-diethylamino)ethyl methacrylate-co-t-butyl methacrylate microgel particles to give (2-diethylamino)ethyl methacrylate-co-methacrylic acid microgel particles. The hydrodynamic diameter and electrophoretic mobility of both the pre-hydrolyzed and post-hydrolyzed microgel particles have been investigated as a function of pH for three microgel dispersions differing in their monomer compositions. The swelling properties and isoelectric point pH are shown to depend on the monomer composition.

Acknowledgements

MB and BV would like to acknowledge GSK, New Products Research, Oral Healthcare R&D, Weybridge, UK, for provision of research funds to enable this research to be carried out.

References

Biocompatible, Polyampholyte Microgel Particles

Abstract

Acknowledgements

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