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Australian Journal of Biological Sciences Australian Journal of Biological Sciences Society
Biological Sciences
RESEARCH ARTICLE

Immunization of Sheep With Larval Antigens of Lucilia cuprina

IJ O'Donnell, PE Green, JA Connell and PS Hopkins

Australian Journal of Biological Sciences 34(4) 411 - 418
Published: 1981

Abstract

Sheep were immunized with antigens extracted from third-instar larvae of L. cuprina. This procedure produced substantial titres of circulating antibody as measured by solid-phase radioimmunoassay or immunodiffusion or by both techniques. However, immunization did not confer protection against subsequent implant challenge with first-instar larvae. In vitro studies indicated that pooled sera from immunized sheep (mean immunodiffusion titre = 3) significantly reduced larval survival. Antigen specificity and the modulating effects of concomitant humoral responses to larval challenge are discussed in relation to the findings.

https://doi.org/10.1071/BI9810411

© CSIRO 1981

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