Induction of Deciduomata in Normal and Histamine-Depleted Rats

Abstract

In the rat large deciduomata were obtained by crushing and by intra-uterine injections of saline, peanut oil, or compound 48/80. Effects of injections of saline made with a 28-gauge needle were largely confined to the site of insertion, but injections made with a 26-gauge needle induced very large, full-length deciduomata almost as large as those produced by crushing. Three histamine-releasing agents were given intraperitoneally: pyrathiazine which induced large deciduomata and damaged the abdominal organs, and compound 48/80 and polymyxin B which were non-irritant and did not induce deciduomata