Register      Login
Crop and Pasture Science Crop and Pasture Science Society
Plant sciences, sustainable farming systems and food quality
RESEARCH ARTICLE

Some effects of carbon tetrachloride intoxication on liver and kidney function in sheep.

BP Setchell

Australian Journal of Agricultural Research 12(5) 944 - 959
Published: 1961

Abstract

Observations have been made of the effect of toxic doses of carbon tetrachloride per os on bromsulphthalein clearance, p-aminohippurate synthesis from p-aminobenzoate, plasma concentrations of bilirubin, glutamate oxalacetate and glutamate pyruvate transaminase, protein fractions, creatinine, urea, creatine, "guanidine", phenols, potassium, sodium, calcium, lipid fractions and amino acids, prothrombin time, blood ammonia concentrations, urine volume, specific gravity, osmolarity, protein concentration, and p-aminohippurate and creahine clearances. It was found that a marked degree of both kidney and liver dysfunction followed administration of carbon tetrachloride. There was a similar degree of liver dysfunction in those sheep that died and in those that survived. Kidney dysfunction was much more severe in those animals that died. The kidney dysfunction preceded the symptoms in all cases.

https://doi.org/10.1071/AR9610944

© CSIRO 1961

Committee on Publication Ethics


Export Citation Get Permission

View Dimensions