Some effects of carbon tetrachloride intoxication on liver and kidney function in sheep.

Abstract

Observations have been made of the effect of toxic doses of carbon tetrachloride per os on bromsulphthalein clearance, p-aminohippurate synthesis from p-aminobenzoate, plasma concentrations of bilirubin, glutamate oxalacetate and glutamate pyruvate transaminase, protein fractions, creatinine, urea, creatine, "guanidine", phenols, potassium, sodium, calcium, lipid fractions and amino acids, prothrombin time, blood ammonia concentrations, urine volume, specific gravity, osmolarity, protein concentration, and p-aminohippurate and creahine clearances. It was found that a marked degree of both kidney and liver dysfunction followed administration of carbon tetrachloride. There was a similar degree of liver dysfunction in those sheep that died and in those that survived. Kidney dysfunction was much more severe in those animals that died. The kidney dysfunction preceded the symptoms in all cases.