A test of kidney and liver function in wethers

Abstract

Para-aminohippurate (PAH) and para-aminobenzoate (PAB) are estimated in plasma and urine from wethers after a subcutaneous injection of PAB. The rate of synthesis of PAH from injected PL4B is taken as a measure of liver function and the rate of urinary excretion of the synthesized PAH as a measure of kidney function. It is shown that extrahepatic synthesis of PAH from PAB is unlikely to interfere with these tests of function. Some values for normal animals are given.