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RESEARCH ARTICLE
Contents Vol 64(5)

Geographic distribution of a missense mutation in the KRT38 gene in Chinese indigenous cattle breeds

Jialei Chen A B , Xin Liu B , Jianyong Liu A , Jicai Zhang A , Bizhi Huang https://orcid.org/0000-0003-4308-2838 A * and Chuzhao Lei https://orcid.org/0000-0003-1647-1037 B *
+ Author Affiliations
- Author Affiliations

A Yunnan Academy of Grassland and Animal Science, Kunming, China.

B Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.

* Correspondence to: hbz@ynbp.cn, leichuzhao1118@126.com

Handling Editor: Marina Fortes

Animal Production Science 64, AN22455 https://doi.org/10.1071/AN22455
Submitted: 14 December 2022  Accepted: 20 February 2024  Published: 7 March 2024

© 2024 The Author(s) (or their employer(s)). Published by CSIRO Publishing

Abstract

Context

China has a vast area across many temperature zones and a variety of cattle breeds. These cattle resources are ideal models to research their adaptability to the environment. The KRT38 gene is an acidic protein, and its coding product can be used as a component of hair production.

Aims

The objective of this study was to investigate the diversity of the KRT38 gene in Chinese local cattle and the association of different genotypes with mean temperature, relative humidity and temperature humidity index.

Methods

A missense mutation g.41650738 A > G in the KRT38 gene was screened from the database of bovine genomic variation (BGVD) and was genotyped in a total of 246 samples from 15 local cattle breeds in China by polymerase chain reaction amplification and sequencing. Finally, the correlation between the locus and the three climatic factors was analysed.

Key results

We successfully obtained the frequency of this single-nucelotide polymorphism in three groups of cattle in northern, central and southern China. The frequency of allele A gradually declined from north to south, whereas the frequency of allele G showed the opposite trend with a clear geographic distribution.

Conclusions

Our results indicate that KRT38 variation in Chinese indigenous cattle might be linked to heat tolerance.

Implications

Our analysis may assist in determining the importance of the variation as a genetic signal for heat tolerance in cattle reproduction and genetics.

Keywords: breeding, cattle, climatic, geographical distribution, heat tolerance, KRT38, missense mutation, single nucleotide polymorphism (SNP).

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