Microbiome engineering to combat antimicrobial resistance and upsurge productivity of food animals: a systematic review
Al-Reem A. Johar A , Lubna I. Abu-Rub B , Hassan Al Mana B , Hadi M. Yassine B and Nahla O. Eltai
B *
+ Author Affiliations
- Author Affiliations
A Research and Development Department, Barzan Holdings, Doha 7178, Qatar.
B Microbiology Department, Biomedical Research Centre, Qatar University, Doha 2713, Qatar.
Animal Production Science 63(2) 101-112 https://doi.org/10.1071/AN22233
Submitted: 24 June 2022 Accepted: 10 August 2022 Published: 12 September 2022
© 2023 The Author(s) (or their employer(s)). Published by CSIRO Publishing. This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND)
Abstract
Extensive antimicrobial usage in animal farming plays a prominent role in the antimicrobial resistance (AMR) crisis and is repeatedly highlighted as an area needing development under the ‘One Health’ approach. Alternative therapies such as microbiome products can be used as prophylaxis to help avoid infectious disease. However, a limited number of studies have focused on AMR-targeted microbiome products. We conducted this systematic review by using PRISMA guidelines to screen for literature that have evaluated food animals’ health when administrated with microbiome products targeting antimicrobial resistance (AMR) or antibiotic-resistant genes (ARGs). We searched and examined studies from SCOPUS, Web of Science, Embase, and Science direct databases for studies published up to November 2021, restricted to the English language. The findings of this review showed that microbiome products have a promising capability to tackle specific AMR/ARGs coupled with animal’s health and productivity improvement. Furthermore, our study showed that probiotics were the most favourable tested microbiome products, with the most targeted resistance being to tetracycline, macrolides, and beta-lactams. While microbiome products are promising alternatives to antibiotic prophylactics, there is a dearth of studies investigating their efficacy in targeting AMR. Thus, it is highly recommended to further investigate, develop, and improve the microbiome, to better understand their utility and circumvent their limitations.
Keywords: AMR, antimicrobials, ARG, bacteria, food animals, microbiome, microbiome products, probiotics.
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