Induction of hypocalcaemia and evaluation of reticuloruminal motility using a three-axis accelerometer
Woojae Choi A , Younghye Ro A , Dohee Kim A , Leegon Hong A and Danil Kim
A B *
A Department of Farm Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea.
B Farm Animal Clinical Training and Research Center, Institutes of Green-Bio Science and Technology, Seoul National University, Pyeongchang 25354, Republic of Korea.
Animal Production Science 62(5) 409-415 https://doi.org/10.1071/AN21532
Submitted: 18 October 2021 Accepted: 21 December 2021 Published: 3 February 2022
© 2022 The Author(s) (or their employer(s)). Published by CSIRO Publishing. This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND)
Abstract
Context: Reticuloruminal motility, which is continuous and regular, is essential for digestive activity, but some functional abnormalities can appear in cattle with several metabolic disorders. Particularly in periparturient dairy cows, decreased blood calcium concentrations induce deterioration of rumen motility as well as the risk of reproductive disorders.
Aims: This study aimed to evaluate reticuloruminal motility using a bolus-type biosensor incorporated with a three-axis accelerometer (3XA) following induction of hypocalcaemia by infusion of ethylenediamine–tetraacetic acid disodium salt dihydrate (Na2EDTA) solution.
Methods: In the 2 × 2 crossover experiment, six non-pregnant and non-lactating cows were assigned to each of the treatment (TRE) and control (CON) groups and infused for 1 h with 13% Na2EDTA solution and physiological saline respectively. The cylindrical biosensor was fed and placed in the reticulum before the experiment, and the three acceleration values of each cow were recorded and transmitted wirelessly. Considering the device shape, the reticuloruminal motility was represented as the vector value (V2) calculated with each change in X- and Z-axis acceleration over time.
Key results: Plasma calcium concentrations were measured to confirm hypocalcaemia, and the average was significantly decreased to 1.23 mmol/L at 1 h in TRE. The mean V2 value was significantly decreased in TRE compared with CON, from 1 to 2 h after Na2EDTA infusion.
Conclusion: 3XA was able to detect a change in reticuloruminal motility caused by hypocalcaemia. The use of 3XA in cattle will allow for rapid treatment of hypocalcaemia or other metabolic disorders that reduce productivity.
Implications: The 3XA inserted into the reticulum of a dairy cow detected a decrease in reticuloruminal motility wirelessly caused by induced hypocalcaemia.
Keywords: dairy cows, detection of periparturient disease, calcium, forestomach motility in cattle, induced hypocalcaemia, remote sensing, smart farming, three-axis accelerometer.
References
AlZahal O, AlZahal H, Steele MA, Van Schaik M, Kyriazakis I, Duffield TF, McBride BW (2011) The use of a radiotelemetric ruminal bolus to detect body temperature changes in lactating dairy cattle. Journal of Dairy Science 94, 3568–3574.| The use of a radiotelemetric ruminal bolus to detect body temperature changes in lactating dairy cattle.Crossref | GoogleScholarGoogle Scholar | 21700044PubMed |
Arai S, Okada H, Sawada H, Takahashi Y, Kimura K, Itoh T (2019) Evaluation of ruminal motility in cattle by a bolus-type wireless sensor. Journal of Veterinary Medical Science 81, 1835–1841.
| Evaluation of ruminal motility in cattle by a bolus-type wireless sensor.Crossref | GoogleScholarGoogle Scholar |
Armstrong CM, Cota G (1999) Calcium block of Na+ channels and its effect on closing rate. Proceedings of the National Academy of Sciences of the United States of America 96, 4154–4157.
| Calcium block of Na+ channels and its effect on closing rate.Crossref | GoogleScholarGoogle Scholar | 10097179PubMed |
Bedford A, Beckett L, Harthan L, Wang C, Jiang N, Schramm H, Guan LL, Daniels KM, Hanigan MD, White RR (2020) Ruminal volatile fatty acid absorption is affected by elevated ambient temperature. Scientific Reports 10, 13092
| Ruminal volatile fatty acid absorption is affected by elevated ambient temperature.Crossref | GoogleScholarGoogle Scholar | 32753682PubMed |
Blaine J, Chonchol M, Levi M (2015) Renal control of calcium, phosphate, and magnesium homeostasis. Clinical Journal of the American Society of Nephrology 10, 1257–1272.
| Renal control of calcium, phosphate, and magnesium homeostasis.Crossref | GoogleScholarGoogle Scholar | 25287933PubMed |
Choi W, Ro Y, Hong L, Ahn S, Kim H, Choi C, Kim H, Kim D (2020) Evaluation of ruminal motility using an indwelling 3-axis accelerometer in the reticulum in cattle. Journal of Veterinary Medical Science 82, 1750–1756.
| Evaluation of ruminal motility using an indwelling 3-axis accelerometer in the reticulum in cattle.Crossref | GoogleScholarGoogle Scholar |
Desmecht DJ-M, Linden AS, Godeau J-M, Lekeux PM (1995) Experimental production of hypocalcemia by EDTA infusion in calves: a critical appraisal assessed from the profile of blood chemicals and enzymes. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 110, 115–130.
| Experimental production of hypocalcemia by EDTA infusion in calves: a critical appraisal assessed from the profile of blood chemicals and enzymes.Crossref | GoogleScholarGoogle Scholar |
Foster D (2017) Disorders of rumen distension and dysmotility. Veterinary Clinics of North America: Food Animal Practice 33, 499–512.
| Disorders of rumen distension and dysmotility.Crossref | GoogleScholarGoogle Scholar |
Gallo L, Faniello MC, Canino G, Tripolino C, Gnasso A, Cuda G, Costanzo FS, Irace C (2016) Serum calcium increase correlates with worsening of lipid profile: an observational study on a large cohort from south Italy. Medicine 95, e2774
| Serum calcium increase correlates with worsening of lipid profile: an observational study on a large cohort from south Italy.Crossref | GoogleScholarGoogle Scholar | 26937904PubMed |
Goff JP, Hohman A, Timms LL (2020) Effect of subclinical and clinical hypocalcemia and dietary cation–anion difference on rumination activity in periparturient dairy cows. Journal of Dairy Science 103, 2591–2601.
| Effect of subclinical and clinical hypocalcemia and dietary cation–anion difference on rumination activity in periparturient dairy cows.Crossref | GoogleScholarGoogle Scholar | 31980230PubMed |
Hamilton AW, Davison C, Tachtatzis C, Andonovic I, Michie C, Ferguson HJ, Somerville L, Jonsson NN (2019) Identification of the rumination in cattle using support vector machines with motion-sensitive bolus sensors. Sensors 19, 1165
| Identification of the rumination in cattle using support vector machines with motion-sensitive bolus sensors.Crossref | GoogleScholarGoogle Scholar |
Ivany JM, Rings DM, Anderson DE (2002) Reticuloruminal disturbances in the bovine. The Bovine Practitioner 36, 56–64.
| Reticuloruminal disturbances in the bovine.Crossref | GoogleScholarGoogle Scholar |
Jørgensen RJ, Nyengaard NR, Hara S, Enemark JM, Andersen PH (1998) Rumen motility during induced hyper- and hypocalcaemia. Acta Veterinaria Scandinavica 39, 331–338.
| Rumen motility during induced hyper- and hypocalcaemia.Crossref | GoogleScholarGoogle Scholar | 9787496PubMed |
Jørgensen RJ, Nyengaard NR, Daniel RC, Mellau LS, Enemark JM (1999) Induced hypocalcaemia by Na2EDTA infusion. A review. Journal of Veterinary Medicine Series A 46, 389–407.
| Induced hypocalcaemia by Na2EDTA infusion. A review.Crossref | GoogleScholarGoogle Scholar | 10528534PubMed |
Kronqvist C, Emanuelson U, Spörndly R, Holtenius K (2011) Effects of prepartum dietary calcium level on calcium and magnesium metabolism in periparturient dairy cows. Journal of Dairy Science 94, 1365–1373.
| Effects of prepartum dietary calcium level on calcium and magnesium metabolism in periparturient dairy cows.Crossref | GoogleScholarGoogle Scholar | 21338802PubMed |
LeBlanc SJ, Leslie KE, Duffield TF (2005) Metabolic predictors of displaced abomasum in dairy cattle. Journal of Dairy Science 88, 159–170.
| Metabolic predictors of displaced abomasum in dairy cattle.Crossref | GoogleScholarGoogle Scholar | 15591379PubMed |
Martinez N, Sinedino LDP, Bisinotto RS, Ribeiro ES, Gomes GC, Lima FS, Greco LF, Risco CA, Galvão KN, Taylor-Rodriguez D, Driver JP, Thatcher WW, Santos JEP (2014) Effect of induced subclinical hypocalcemia on physiological responses and neutrophil function in dairy cows. Journal of Dairy Science 97, 874–887.
| Effect of induced subclinical hypocalcemia on physiological responses and neutrophil function in dairy cows.Crossref | GoogleScholarGoogle Scholar | 24359833PubMed |
Mellau LSB, Jørgensen RJ, Enemark JMD (2001) Plasma calcium, inorganic phosphate and magnesium during hypocalcaemia induced by a standardized EDTA infusion in cows. Acta Veterinaria Scandinavica 42, 251–260.
| Plasma calcium, inorganic phosphate and magnesium during hypocalcaemia induced by a standardized EDTA infusion in cows.Crossref | GoogleScholarGoogle Scholar |
Neethirajan S (2017) Recent advances in wearable sensors for animal health management. Sensing and Bio-Sensing Research 12, 15–29.
| Recent advances in wearable sensors for animal health management.Crossref | GoogleScholarGoogle Scholar |
Odongo NE, AlZahal O, Lindinger MI, Duffield TF, Valdes EV, Terrell SP, McBride BW (2006) Effects of mild heat stress and grain challenge on acid–base balance and rumen tissue histology in lambs. Journal of Animal Science 84, 447–455.
| Effects of mild heat stress and grain challenge on acid–base balance and rumen tissue histology in lambs.Crossref | GoogleScholarGoogle Scholar | 16424273PubMed |
Onifade KU, Mohammad AA, Petersen JR, Okorodudu AO (2005) Ionized calcium: indications and advantages of its measurement. Journal of Laboratory Medicine 29, 235–240.
| Ionized calcium: indications and advantages of its measurement.Crossref | GoogleScholarGoogle Scholar |
Perrino BA (2016) Calcium sensitization mechanisms in gastrointestinal smooth muscles. Journal of Neurogastroenterology and Motility 22, 213–225.
| Calcium sensitization mechanisms in gastrointestinal smooth muscles.Crossref | GoogleScholarGoogle Scholar | 26701920PubMed |
Ro Y, Choi W, Park J, Choe E, Kim D (2020) Changes in plasma pH and blood and urinary macromineral concentrations in experimentally induced hypocalcemic cows with Na2EDTA. Journal of Veterinary Medical Science 82, 962–966.
| Changes in plasma pH and blood and urinary macromineral concentrations in experimentally induced hypocalcemic cows with Na2EDTA.Crossref | GoogleScholarGoogle Scholar |
Rodríguez EM, Arís A, Bach A (2017) Associations between subclinical hypocalcaemia and postparturient diseases in dairy cows. Journal of Dairy Science 100, 7427–7434.
| Associations between subclinical hypocalcaemia and postparturient diseases in dairy cows.Crossref | GoogleScholarGoogle Scholar | 28690056PubMed |
Sasaki K, Yamagishi N, Kizaki K, Sasaki K, Devkota B, Hashizume K (2014) Microarray-based gene expression profiling of peripheral blood mononuclear cells in dairy cows with experimental hypocalcemia and milk fever. Journal of Dairy Science 97, 247–258.
| Microarray-based gene expression profiling of peripheral blood mononuclear cells in dairy cows with experimental hypocalcemia and milk fever.Crossref | GoogleScholarGoogle Scholar | 24210493PubMed |
Seifi HA, LeBlanc SJ, Leslie KE, Duffield TF (2011) Metabolic predictors of post-partum disease and culling risk in dairy cattle. The Veterinary Journal 188, 216–220.
| Metabolic predictors of post-partum disease and culling risk in dairy cattle.Crossref | GoogleScholarGoogle Scholar | 20457532PubMed |
Stevenson JS, Hill SL, Nebel RL, DeJarnette JM (2014) Ovulation timing and conception risk after automated activity monitoring in lactating dairy cows. Journal of Dairy Science 97, 4296–4308.
| Ovulation timing and conception risk after automated activity monitoring in lactating dairy cows.Crossref | GoogleScholarGoogle Scholar | 24819138PubMed |
Venjakob PL, Pieper L, Heuwieser W, Borchardt S (2018) Association of postpartum hypocalcemia with early-lactation milk yield, reproductive performance, and culling in dairy cows. Journal of Dairy Science 101, 9396–9405.
| Association of postpartum hypocalcemia with early-lactation milk yield, reproductive performance, and culling in dairy cows.Crossref | GoogleScholarGoogle Scholar | 30031579PubMed |
Wierzbicka M, Domino M, Zabielski R, Gajewski Z (2021) Long-term recording of reticulo-rumen myoelectrical activity in sheep by a telemetry method. Animals 11, 1052
| Long-term recording of reticulo-rumen myoelectrical activity in sheep by a telemetry method.Crossref | GoogleScholarGoogle Scholar | 33917991PubMed |
Wolfger B, Timsit E, Pajor EA, Cook N, Barkema HW, Orsel K (2015) Technical note: accuracy of an ear tag-attached accelerometer to monitor rumination and feeding behavior in feedlot cattle. Journal of Animal Science 93, 3164–3168.
| Technical note: accuracy of an ear tag-attached accelerometer to monitor rumination and feeding behavior in feedlot cattle.Crossref | GoogleScholarGoogle Scholar | 26115302PubMed |
