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Animal Production Science Animal Production Science Society
Food, fibre and pharmaceuticals from animals
REVIEW

Recent advances in the use of phytochemicals to manage gastrointestinal oxidative stress in poultry and pigs

J. J. Cottrell https://orcid.org/0000-0002-1899-2090 A D , H. H. Le A , O. Artaiz A , Y. Iqbal A , H. A. Suleria A , A. Ali https://orcid.org/0000-0002-2160-9451 A , P. Celi A B and F. R. Dunshea A C
+ Author Affiliations
- Author Affiliations

A Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Royal Parade, Melbourne, Vic. 3010, Australia.

B Adisseo Asia Pacific Pty Ltd, 600 North Bridge Road #15-06, Parkview Square, Singapore 188788, Singapore.

C Faculty of Biological Sciences, The University of Leeds, Leeds LS2 9JT, UK.

D Corresponding author. Email: jcottrell@unimelb.edu.au

Animal Production Science 62(12) 1140-1146 https://doi.org/10.1071/AN20667
Submitted: 13 December 2020  Accepted: 22 April 2021   Published: 25 June 2021

Abstract

Plants are integral components of pig and poultry feed, and aside from their raw nutritive value, some phytochemicals contain bioactive compounds. The aim of the present paper is to review recent advances in the use of some phytochemicals in pig and poultry feed, focusing on the examples of isoquinoline alkaloids, polyphenol rich sugarcane extracts and superoxide dismutase-rich melon pulp extracts. As gut health is critical for efficient production, the review will focus on recent results modulating oxidative stress within the gastrointestinal tract and the potential mechanisms of action.

Keywords: phytochemical, antioxidant, oxidative stress, gastrointestinal tract, alkaloid.


References

Ahasan ASML, Invernizzi G, Farina G, Pilotto A, Barbé F, Bontempo V, Rossi R, Bellagamba F, Lecchi C, Savoini G, Agazzi A (2019) The effects of superoxide dismutase-rich melon pulp concentrate on inflammation, antioxidant status and growth performance of challenged post-weaning piglets. Animal 13, 136–143.
The effects of superoxide dismutase-rich melon pulp concentrate on inflammation, antioxidant status and growth performance of challenged post-weaning piglets.Crossref | GoogleScholarGoogle Scholar | 29909802PubMed |

Ahlawat S, Xie F, Zhu Y, D’Hondt R, Ding X, Zhang Q-Y, Mantis NJ (2014) Mice deficient in intestinal epithelium cytochrome P450 reductase are prone to acute toxin-induced mucosal damage. Scientific Reports 4, 5551
Mice deficient in intestinal epithelium cytochrome P450 reductase are prone to acute toxin-induced mucosal damage.Crossref | GoogleScholarGoogle Scholar | 24989705PubMed |

Akbarian A, Michiels J, Degroote J, Majdeddin M, Golian A, De Smet S (2016) Association between heat stress and oxidative stress in poultry; mitochondrial dysfunction and dietary interventions with phytochemicals. Journal of Animal Science and Biotechnology 7, 37
Association between heat stress and oxidative stress in poultry; mitochondrial dysfunction and dietary interventions with phytochemicals.Crossref | GoogleScholarGoogle Scholar | 27354915PubMed |

Artuso-Ponte V, Moeller S, Rajala-Schultz P, Medardus JJ, Munyalo J, Lim K, Gebreyes WA (2015) Supplementation with quaternary benzo(c)phenanthridine alkaloids decreased salivary cortisol and salmonella shedding in pigs after transportation to the slaughterhouse. Foodborne Pathogens and Disease 12, 891–897.
Supplementation with quaternary benzo(c)phenanthridine alkaloids decreased salivary cortisol and salmonella shedding in pigs after transportation to the slaughterhouse.Crossref | GoogleScholarGoogle Scholar | 26393495PubMed |

Bavarsadi M, Mahdavi AH, Ansari-Mahyari S, Jahanian E (2017) Effects of different levels of sanguinarine on antioxidant indices, immunological responses, ileal microbial counts and jejunal morphology of laying hens fed diets with different levels of crude protein. Journal of Animal Physiology and Animal Nutrition 101, 936–948.
Effects of different levels of sanguinarine on antioxidant indices, immunological responses, ileal microbial counts and jejunal morphology of laying hens fed diets with different levels of crude protein.Crossref | GoogleScholarGoogle Scholar | 27272257PubMed |

Bribi N (2018) Pharmacological activity of alkaloids: a review. Asian Journal of Botany 1, 1–6.

Brooks CC, Iwanaga II (1967) Use of Cane Molasses in Swine Diets. Journal of Animal Science 26, 741–745.
Use of Cane Molasses in Swine Diets.Crossref | GoogleScholarGoogle Scholar | 6076865PubMed |

Carillon J, Barbé F, Barial S, Saby M, Sacy A, Rouanet JM (2016) Diet supplementation with a specific melon concentrate improves oviduct antioxidant defenses and egg characteristics in laying hens. Poultry Science 95, 1898–1904.
Diet supplementation with a specific melon concentrate improves oviduct antioxidant defenses and egg characteristics in laying hens.Crossref | GoogleScholarGoogle Scholar | 27143774PubMed |

Celi P, Cowieson A, Fru-Nji F, Steinert R, Kluenter A-M, Verlhac V (2017) Gastrointestinal functionality in animal nutrition and health: new opportunities for sustainable animal production. Animal Feed Science and Technology 234, 88–100.
Gastrointestinal functionality in animal nutrition and health: new opportunities for sustainable animal production.Crossref | GoogleScholarGoogle Scholar |

Celi P, Verlhac V, Pérez Calvo E, Schmeisser J, Kluenter AM (2019) Biomarkers of gastrointestinal functionality in animal nutrition and health. Animal Feed Science and Technology 250, 9–31.
Biomarkers of gastrointestinal functionality in animal nutrition and health.Crossref | GoogleScholarGoogle Scholar |

Chen J, Kang B, Yao K, Fu C, Zhao Y (2019) Effects of dietary Macleaya cordata extract on growth performance, immune responses, antioxidant capacity, and intestinal development in weaned piglets. Journal of Applied Animal Research 47, 349–356.
Effects of dietary Macleaya cordata extract on growth performance, immune responses, antioxidant capacity, and intestinal development in weaned piglets.Crossref | GoogleScholarGoogle Scholar |

Colombo ML, Bosisio E (1996) Pharmacological activities of Chelidonium majus L. (Papaveraceae). Pharmacological Research 33, 127–134.
Pharmacological activities of Chelidonium majus L. (Papaveraceae).Crossref | GoogleScholarGoogle Scholar | 8870028PubMed |

Cottrell JJ, Liu F, Hung AT, DiGiacomo K, Chauhan SS, Leury BJ, Furness JB, Celi P, Dunshea FR (2015) Nutritional strategies to alleviate heat stress in pigs. Animal Production Science 55, 1391–1402.
Nutritional strategies to alleviate heat stress in pigs.Crossref | GoogleScholarGoogle Scholar |

Cui Y, Gu X (2015) Proteomic changes of the porcine small intestine in response to chronic heat stress. Journal of Molecular Endocrinology 55, 277–293.
Proteomic changes of the porcine small intestine in response to chronic heat stress.Crossref | GoogleScholarGoogle Scholar | 26416815PubMed |

Deseo MA, Elkins A, Rochfort S, Kitchen B (2020) Antioxidant activity and polyphenol composition of sugarcane molasses extract. Food Chemistry 314, 126180
Antioxidant activity and polyphenol composition of sugarcane molasses extract.Crossref | GoogleScholarGoogle Scholar | 31954937PubMed |

Dey  PKundu  AKumar  AGupta  MLee  BMBhakta  TDash  SKim  HS (2020 ) Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids).Recent Advances in Natural Products Analysis505567

DiMenna ME, Mortimer PH, Prestidge RA, Hawkes AD, Sprosen JM (1992) Lolitrem B concentrations, counts of Acremonium lolii hyphae, and the incidence of ryegrass staggers in lambs on plots of A. lolii-infected perennial ryegrass. New Zealand Journal of Agricultural Research 35, 211–217.
Lolitrem B concentrations, counts of Acremonium lolii hyphae, and the incidence of ryegrass staggers in lambs on plots of A. lolii-infected perennial ryegrass.Crossref | GoogleScholarGoogle Scholar |

Dvorák Z, Simánek V (2007) Metabolism of sanguinarine: the facts and the myths. Current Drug Metabolism 8, 173–176.
Metabolism of sanguinarine: the facts and the myths.Crossref | GoogleScholarGoogle Scholar | 17305495PubMed |

Furness JB, Cottrell JJ, Bravo DM (2015) Comparative gut physiology Symposium: comparative physiology of digestion. Journal of Animal Science 93, 485–491.
Comparative gut physiology Symposium: comparative physiology of digestion.Crossref | GoogleScholarGoogle Scholar | 26020739PubMed |

Gabler NK, Pearce SC (2015) The impact of heat stress on intestinal function and productivity in grow–finish pigs. Animal Production Science 55, 1403–1410.
The impact of heat stress on intestinal function and productivity in grow–finish pigs.Crossref | GoogleScholarGoogle Scholar |

Gilca M, Gaman L, Panait E, Stoian I, Atanasiu V (2010) Chelidonium majus: an integrative review: traditional knowledge versus modern findings. Complementary Medicine Research 17, 241–248.
Chelidonium majus: an integrative review: traditional knowledge versus modern findings.Crossref | GoogleScholarGoogle Scholar |

Godowski KC (1989) Antimicrobial action of sanguinarine. The Journal of Clinical Dentistry 1, 96–101.

Gu C, Howell K, Padayachee A, Comino T, Chhan R, Zhang P, Ng K, Cottrell JJ, Dunshea FR (2019) Effect of a polyphenol-rich plant matrix on colonic digestion and plasma antioxidant capacity in a porcine model. Journal of Functional Foods 57, 211–221.
Effect of a polyphenol-rich plant matrix on colonic digestion and plasma antioxidant capacity in a porcine model.Crossref | GoogleScholarGoogle Scholar |

Guerre P (2015) Ergot alkaloids produced by endophytic fungi of the genus Epichloë. Toxins 7, 773–790.
Ergot alkaloids produced by endophytic fungi of the genus Epichloë.Crossref | GoogleScholarGoogle Scholar | 25756954PubMed |

Gülçin İ (2012) Antioxidant activity of food constituents: an overview. Archives of Toxicology 86, 345–391.
Antioxidant activity of food constituents: an overview.Crossref | GoogleScholarGoogle Scholar | 22102161PubMed |

Habibu B, Ikira NM, Buhari HU, Aluwong T, Kawu MU, Yaqub LS, Tauheed M, Isa HI (2014) Effect of molasses supplementation on live weight gain, haematologic parameters and erythrocyte osmotic fragility of broiler chickens in the hot-dry season. International Journal of Veterinary Science 3, 181–188.

Hallstrom CK, Gardner AM, Gardner PR (2004) Nitric oxide metabolism in mammalian cells: substrate and inhibitor profiles of a NADPH-cytochrome P450 oxidoreductase-coupled microsomal nitric oxide dioxygenase. Free Radical Biology & Medicine 37, 216–228.
Nitric oxide metabolism in mammalian cells: substrate and inhibitor profiles of a NADPH-cytochrome P450 oxidoreductase-coupled microsomal nitric oxide dioxygenase.Crossref | GoogleScholarGoogle Scholar |

Hori Y, Hoshino J, Yamazaki C, Sekiguchi T, Miyauchi S, Mizuno S, Horie K (1997) Effect of lecithinized-superoxide dismutase on the rat colitis model induced by dextran sulfate sodium. Japanese Journal of Pharmacology 74, 99–103.
Effect of lecithinized-superoxide dismutase on the rat colitis model induced by dextran sulfate sodium.Crossref | GoogleScholarGoogle Scholar | 9195304PubMed |

Hu N-X, Chen M, Liu Y-S, Shi Q, Yang B, Zhang H-C, Cheng P, Tang Q, Liu Z-Y, Zeng J-G (2019) Pharmacokinetics of sanguinarine, chelerythrine, and their metabolites in broiler chickens following oral and intravenous administration. Journal of Veterinary Pharmacology and Therapeutics 42, 197–206.
Pharmacokinetics of sanguinarine, chelerythrine, and their metabolites in broiler chickens following oral and intravenous administration.Crossref | GoogleScholarGoogle Scholar | 30350369PubMed |

Huang H, Yao J, Liu K, Yang W, Wang G, Shi C, Jiang Y, Wang J, Kang Y, Wang D, Wang C, Yang G (2020) Sanguinarine has anthelmintic activity against the enteral and parenteral phases of trichinella infection in experimentally infected mice. Acta Tropica 201, 105226
Sanguinarine has anthelmintic activity against the enteral and parenteral phases of trichinella infection in experimentally infected mice.Crossref | GoogleScholarGoogle Scholar | 31634454PubMed |

Igarashi R, Hoshino J, Takenaga M, Kawai S, Morizawa Y, Yasuda A, Otani M, Mizushima Y (1992) Lecithinization of superoxide dismutase potentiates its protective effect against Forssman antiserum-induced elevation in guinea pig airway resistance. The Journal of Pharmacology and Experimental Therapeutics 262, 1214–1219.

Iqbal Y, Cottrell JJ, Suleria HA, Dunshea FR (2020) Gut microbiota-polyphenol interactions in chicken: a review. Animals (Basel) 10, 1391
Gut microbiota-polyphenol interactions in chicken: a review.Crossref | GoogleScholarGoogle Scholar |

Jankowski J, Zduńczyk Z, Juśkiewicz J, Kozłowski K, Lecewicz A, Jeroch H (2009) Gastrointestinal tract and metabolic response of broilers to diets with the Macleaya cordata alkaloid extract. Archiv für Geflügelkunde 73, 95–101.

Ji J, Yang X, Flavel M, Shields ZPI, Kitchen B (2019) Antioxidant and anti-diabetic functions of a polyphenol-rich sugarcane extract. Journal of the American College of Nutrition 38, 670–680.
Antioxidant and anti-diabetic functions of a polyphenol-rich sugarcane extract.Crossref | GoogleScholarGoogle Scholar | 31008696PubMed |

Ji J, Flavel M, Yang X, Chen OCY, Downey L, Stough C, Kitchen B (2020) A polyphenol rich sugarcane extract as a modulator for inflammation and neurological disorders. PharmaNutrition 12, 100187
A polyphenol rich sugarcane extract as a modulator for inflammation and neurological disorders.Crossref | GoogleScholarGoogle Scholar |

Juskiewicz J, Gruzauskas R, Zdunczyk Z, Semaskaite A, Jankowski J, Totilas Z, Jarule V, Sasyte V, Zdunczyk P, Raceviciute-Stupeliene A, Svirmickas G (2011) Effects of dietary addition of Macleaya cordata alkaloid extract on growth performance, caecal indices and breast meat fatty acids profile in male broilers. Journal of Animal Physiology and Animal Nutrition 95, 171–178.
Effects of dietary addition of Macleaya cordata alkaloid extract on growth performance, caecal indices and breast meat fatty acids profile in male broilers.Crossref | GoogleScholarGoogle Scholar | 20666860PubMed |

Karamitros D (1987) Sugar beet molasses for growing and fattening pigs. Animal Feed Science and Technology 18, 131–142.
Sugar beet molasses for growing and fattening pigs.Crossref | GoogleScholarGoogle Scholar |

Khadem A, Soler L, Everaert N, Niewold TA (2014) Growth promotion in broilers by both oxytetracycline and Macleaya cordata extract is based on their anti-inflammatory properties. British Journal of Nutrition 112, 1110–1118.
Growth promotion in broilers by both oxytetracycline and Macleaya cordata extract is based on their anti-inflammatory properties.Crossref | GoogleScholarGoogle Scholar |

Kikusato M, Xue G, Pastor A, Niewold TA, Toyomizu M (2020) Effects of plant-derived isoquinoline alkaloids on growth performance and intestinal function of broiler chickens under heat stress. Poultry Science 100, 957–963.

Knaus UG (2020) ROS signaling in complex systems: the gut. In ‘Oxidative stress’. pp. 695–712. (Elsevier)

Kosina P, Gregorova J, Gruz J, Vacek J, Kolar M, Vogel M, Roos W, Naumann K, Simanek V, Ulrichova J (2010) Phytochemical and antimicrobial characterization of Macleaya cordata herb. Fitoterapia 81, 1006–1012.

Kosina P, Walterová D, Ulrichová J, Lichnovský V, Stiborová M, Rýdlová H, Vicar J, Krecman V, Brabec MJ, Simánek V (2004) Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment. Food and Chemical Toxicology 42, 85–91.

Kumar A, Ekavali , Chopra K, Mukherjee M, Pottabathini R, Dhull DK (2015) Current knowledge and pharmacological profile of berberine: an update. European Journal of Pharmacology 761, 288–297.
Current knowledge and pharmacological profile of berberine: an update.Crossref | GoogleScholarGoogle Scholar | 26092760PubMed |

Lallès JP, Lacan D, David JC (2011) A melon pulp concentrate rich in superoxide dismutase reduces stress proteins along the gastrointestinal tract of pigs. Nutrition 27, 358–363.
A melon pulp concentrate rich in superoxide dismutase reduces stress proteins along the gastrointestinal tract of pigs.Crossref | GoogleScholarGoogle Scholar | 20558040PubMed |

Le HH, Shakeri M, Suleria HAR, Zhao W, McQuade RM, Phillips DJ, Vidacs E, Furness JB, Dunshea FR, Artuso-Ponte V, Cottrell JJ (2020) Betaine and Isoquinoline alkaloids protect against heat stress and colonic permeability in growing pigs. Antioxidants 9,

Le HH, Vidacs E, Phillips DJ, Zhao W, Furness JB, Gabler NK, Renaudeau D, Wijffels G, Dunshea FR, DiGiacomo K (2019) PSIV-8 Effect of selenium and superoxide dismutase supplementation on heat stressed pigs. Journal of Animal Science 97, 179
PSIV-8 Effect of selenium and superoxide dismutase supplementation on heat stressed pigs.Crossref | GoogleScholarGoogle Scholar |

Lee K-W, Kim J-S, Oh S-T, Kang C-W, An B-K (2015) Effects of dietary sanguinarine on growth performance, relative organ weight, cecal microflora, serum cholesterol level and meat quality in broiler chickens. Journal of Poultry Science 52, 15–22.
Effects of dietary sanguinarine on growth performance, relative organ weight, cecal microflora, serum cholesterol level and meat quality in broiler chickens.Crossref | GoogleScholarGoogle Scholar |

Li B, Zhang J-q, Han X-g, Wang Z-l, Xu Y-y, Miao J-f (2018) Macleaya cordata helps improve the growth-promoting effect of chlortetracycline on broiler chickens. Journal of Zhejiang University. Science. B. 19, 776–784.
Macleaya cordata helps improve the growth-promoting effect of chlortetracycline on broiler chickens.Crossref | GoogleScholarGoogle Scholar | 30269445PubMed |

Lillehoj HS, Kim DK, Bravo DM, Lee SH (2011) Effects of dietary plant-derived phytonutrients on the genome-wide profiles and coccidiosis resistance in the broiler chickens. BMC Proceedings 5, S34–S41.
Effects of dietary plant-derived phytonutrients on the genome-wide profiles and coccidiosis resistance in the broiler chickens.Crossref | GoogleScholarGoogle Scholar | 21645315PubMed |

Lin W, Kuang Y, Wang J, Duan D, Xu W, Tian P, Nzabanita C, Wang M, Li M, Ma B (2019) Effects of seasonal variation on the alkaloids of different ecotypes of Epichloë endophyte-Festuca sinensis associations. Frontiers in Microbiology 10, 1695
Effects of seasonal variation on the alkaloids of different ecotypes of Epichloë endophyte-Festuca sinensis associations.Crossref | GoogleScholarGoogle Scholar | 31402903PubMed |

Liu F, Yin J, Du M, Yan P, Xu J, Zhu X, Yu J (2009) Heat-stress-induced damage to porcine small intestinal epithelium associated with downregulation of epithelial growth factor signaling. Journal of Animal Science 87, 1941–1949.
Heat-stress-induced damage to porcine small intestinal epithelium associated with downregulation of epithelial growth factor signaling.Crossref | GoogleScholarGoogle Scholar | 19213704PubMed |

Liu F, Cottrell JJ, Furness JB, Rivera LR, Kelly FW, Wijesiriwardana U, Pustovit RV, Fothergill LJ, Bravo DM, Celi P, Leury BJ, Gabler NK, Dunshea FR (2016a) Selenium and vitamin E together improve intestinal epithelial barrier function and alleviate oxidative stress in heat stressed pigs. Experimental Physiology 101, 801–810.
Selenium and vitamin E together improve intestinal epithelial barrier function and alleviate oxidative stress in heat stressed pigs.Crossref | GoogleScholarGoogle Scholar | 27064134PubMed |

Liu G, Guan G, Fang J, Martínez Y, Chen S, Bin P, Duraipandiyan V, Gong T, Tossou MCB, Al-Dhabi NA, Yin Y (2016b) Macleaya cordata extract decreased diarrhea score and enhanced intestinal barrier function in growing piglets. BioMed Research International 2016, 1069585

Liu ZY, Wang XL, Ou SQ, Hou DX, He JH (2020) Sanguinarine modulate gut microbiome and intestinal morphology to enhance growth performance in broilers. PLoS One 15, e0234920
Sanguinarine modulate gut microbiome and intestinal morphology to enhance growth performance in broilers.Crossref | GoogleScholarGoogle Scholar | 32997725PubMed |

Malinowski DP, Belesky DP (2000) Adaptations of endophyte-infected cool-season grasses to environmental stresses: mechanisms of drought and mineral stress tolerance. Crop Science 40, 923–940.
Adaptations of endophyte-infected cool-season grasses to environmental stresses: mechanisms of drought and mineral stress tolerance.Crossref | GoogleScholarGoogle Scholar |

Molyneux RJ, Lee ST, Gardner DR, Panter KE, James LF (2007) Phytochemicals: the good, the bad and the ugly? Phytochemistry 68, 2973–2985.
Phytochemicals: the good, the bad and the ugly?Crossref | GoogleScholarGoogle Scholar | 17950388PubMed |

Mowat AM (2018) To respond or not to respond: a personal perspective of intestinal tolerance. Nature Reviews. Immunology 18, 405–415.
To respond or not to respond: a personal perspective of intestinal tolerance.Crossref | GoogleScholarGoogle Scholar | 29491358PubMed |

Ni H, Martínez Y, Guan G, Rodríguez R, Más D, Peng H, Valdivié Navarro M, Liu G (2016) Analysis of the Impact of Isoquinoline Alkaloids, Derived from Macleaya cordata Extract, on the Development and Innate Immune Response in Swine and Poultry. BioMed Research International 2016, 1352146
Analysis of the Impact of Isoquinoline Alkaloids, Derived from Macleaya cordata Extract, on the Development and Innate Immune Response in Swine and Poultry.Crossref | GoogleScholarGoogle Scholar | 28042566PubMed |

Obiang-Obounou BW, Kang OH, Choi JG, Keum JH, Kim SB, Mun SH, Shin DW, Kim KW, Park CB, Kim YG, Han SH, Kwon DY (2011) The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus. The Journal of Toxicological Sciences 36, 277–283.
The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus.Crossref | GoogleScholarGoogle Scholar | 21628956PubMed |

Olivas-Aguirre FJ, Mendoza S, Alvarez-Parrilla E, Gonzalez-Aguilar GA, Villegas-Ochoa MA, Quintero-Vargas JTJ, Wall-Medrano A (2020) First-pass metabolism of polyphenols from selected berries: a high-throughput bioanalytical approach. Antioxidants (Basel) 9,

Park JH, Kang SN, Chu GM, Jin SK (2014) Growth performance, blood cell profiles, and meat quality properties of broilers fed with Saposhnikovia divaricata, Lonicera japonica, and Chelidonium majus extracts. Livestock Science 165, 87–94.

Pearce SC, Mani V, Boddicker RL, Johnson JS, Weber TE, Ross JW, Rhoads RP, Baumgard LH, Gabler NK (2013) Heat stress reduces intestinal barrier integrity and favors intestinal glucose transport in growing pigs. PLoS One 8, e70215
Heat stress reduces intestinal barrier integrity and favors intestinal glucose transport in growing pigs.Crossref | GoogleScholarGoogle Scholar | 23936392PubMed |

Piekarska-Radzik L, Klewicka E (2021) Mutual influence of polyphenols and Lactobacillus spp. bacteria in food: a review. European Food Research and Technology 247, 9–24.
Mutual influence of polyphenols and Lactobacillus spp. bacteria in food: a review.Crossref | GoogleScholarGoogle Scholar |

Pircalabioru G, Aviello G, Kubica M, Zhdanov A, Paclet M-H, Brennan L, Hertzberger R, Papkovsky D, Bourke B, Knaus UG (2016) Defensive mutualism rescues NADPH oxidase inactivation in gut infection. Cell Host & Microbe 19, 651–663.
Defensive mutualism rescues NADPH oxidase inactivation in gut infection.Crossref | GoogleScholarGoogle Scholar |

Renaudeau D, Collin A, Yahav S, de Basilio V, Gourdine JL, Collier RJ (2012) Adaptation to hot climate and strategies to alleviate heat stress in livestock production. Animal 6, 707–728.
Adaptation to hot climate and strategies to alleviate heat stress in livestock production.Crossref | GoogleScholarGoogle Scholar | 22558920PubMed |

Robbins RC, Artuso-Ponte VC, Moeser AJ, Morrow WE, Spears JW, Gebreyes WA (2013) Effects of quaternary benzo(c)phenanthridine alkaloids on growth performance, shedding of organisms, and gastrointestinal tract integrity in pigs inoculated with multidrug-resistant Salmonella spp. American Journal of Veterinary Research 74, 1530–1535.
Effects of quaternary benzo(c)phenanthridine alkaloids on growth performance, shedding of organisms, and gastrointestinal tract integrity in pigs inoculated with multidrug-resistant Salmonella spp.Crossref | GoogleScholarGoogle Scholar | 24274891PubMed |

Rojas-Downing MM, Nejadhashemi AP, Harrigan T, Woznicki SA (2017) Climate change and livestock: Impacts, adaptation, and mitigation. Climate Risk Management 16, 145–163.
Climate change and livestock: Impacts, adaptation, and mitigation.Crossref | GoogleScholarGoogle Scholar |

Royer E, Barbé F, Guillou D, Rousselière Y, Chevaux E (2016) Development of an oxidative stress model in weaned pigs highlighting plasma biomarkers’ specificity to stress inducers. Journal of Animal Science 94, 48–53.
Development of an oxidative stress model in weaned pigs highlighting plasma biomarkers’ specificity to stress inducers.Crossref | GoogleScholarGoogle Scholar |

Rundle CM, Artuso-Ponte V, Stein HH (2020) Effects of isoquinoline alkaloids on apparent ileal digestibility of amino acids, acid hydrolyzed ether extract, and starch by young growing pigs fed corn-soybean meal diets. Translational Animal Science 4, txaa054

Sannasimuthu A, Sharma D, Paray BA, Al-Sadoon MK, Arockiaraj J (2020) Intracellular oxidative damage due to antibiotics on gut bacteria reduced by glutathione oxidoreductase-derived antioxidant molecule GM15. Archives of Microbiology 202, 1127–1133.
Intracellular oxidative damage due to antibiotics on gut bacteria reduced by glutathione oxidoreductase-derived antioxidant molecule GM15.Crossref | GoogleScholarGoogle Scholar | 32060599PubMed |

Sauerwein H, Schmitz S, Hiss S (2005) The acute phase protein haptoglobin and its relation to oxidative status in piglets undergoing weaning-induced stress. Redox Report 10, 295–302.
The acute phase protein haptoglobin and its relation to oxidative status in piglets undergoing weaning-induced stress.Crossref | GoogleScholarGoogle Scholar | 16438801PubMed |

Selby-Pham SN, Cottrell JJ, Dunshea FR, Ng K, Bennett LE, Howell KS (2017) Dietary phytochemicals promote health by enhancing antioxidant defence in a pig model. Nutrients 9, 758
Dietary phytochemicals promote health by enhancing antioxidant defence in a pig model.Crossref | GoogleScholarGoogle Scholar |

Shakeri M, Cottrell JJ, Wilkinson S, Le HH, Suleria HA, Warner RD, Dunshea FR (2020) A dietary sugarcane-derived polyphenol mix reduces the negative effects of cyclic heat exposure on growth performance, blood gas status, and meat quality in broiler chickens. Animals 10, 1158
A dietary sugarcane-derived polyphenol mix reduces the negative effects of cyclic heat exposure on growth performance, blood gas status, and meat quality in broiler chickens.Crossref | GoogleScholarGoogle Scholar |

Singh N, Sharma B (2018) Toxicological effects of berberine and sanguinarine. Frontiers in Molecular Biosciences 5,

Straub KD, Carver P (1975) Sanguinarine, inhibitor of Na/K dependent ATP’ase. Biochemical and Biophysical Research Communications 62, 913–922.

Suzuki Y, Matsumoto T, Okamoto S, Hibi T (2008) A lecithinized superoxide dismutase (PC-SOD) improves ulcerative colitis. Colorectal Disease 10, 931–934.

Tandon S, Das M, Khanna SK (1993a) Biometabolic elimination and organ retention profile of argemone alkaloid, sanguinarine, in rats and guinea pigs. Drug Metabolism and Disposition: the Biological Fate of Chemicals 21, 194–197.

Tandon S, Das M, Khanna SK (1993b) Effect of sanguinarine on the transport of essential nutrients in an everted gut sac model: role of Na+, K+-ATPase. Natural Toxins 1, 235–240.
Effect of sanguinarine on the transport of essential nutrients in an everted gut sac model: role of Na+, K+-ATPase.Crossref | GoogleScholarGoogle Scholar | 8167940PubMed |

Večeřa R, Klejdus B, Kosina P, Orolin J, Stiborová M, Smrcek S, Vicar J, Dvorák Z, Ulrichová J, Kubán V, Anzenbacher P, Simánek V (2007) Disposition of sanguinarine in the rat. Xenobiotica 37, 549–558.
Disposition of sanguinarine in the rat.Crossref | GoogleScholarGoogle Scholar | 17523056PubMed |

Vrublova E, Vostalova J, Ehrmann J, Palikova I, Vrbkova J, Vacek J, Cibicek N, Večeřa R, Ulrichova J, Simanek V (2010) The phytogenic feed additive Sangrovit modulates dextran sulfate sodium-induced colitis in rats. Veterinarni Medicina 55, 610–618.
The phytogenic feed additive Sangrovit modulates dextran sulfate sodium-induced colitis in rats.Crossref | GoogleScholarGoogle Scholar |

Wijesiriwardana UA, Pluske JR, Craig JR, Cottrell JJ, Dunshea FR (2020) Evaluation of sugarcane-derived polyphenols on the pre-weaning and post-weaning growth of gilt progeny. Animals 10, 984
Evaluation of sugarcane-derived polyphenols on the pre-weaning and post-weaning growth of gilt progeny.Crossref | GoogleScholarGoogle Scholar |

Wu Y, Zhao NJ, Cao Y, Sun Z, Wang Q, Liu ZY, Sun ZL (2020) Sanguinarine metabolism and pharmacokinetics study in vitro and in vivo. Journal of Veterinary Pharmacology and Therapeutics 43, 208–214.
Sanguinarine metabolism and pharmacokinetics study in vitro and in vivo.Crossref | GoogleScholarGoogle Scholar | 31943246PubMed |

Xie H, Yang J, Feng S, Cheng P, Zeng J, Xiong X (2015) Simultaneous quantitative determination of sanguinarine, chelerythrine, dihydrosanguinarine and dihydrochelerythrine in chicken by HPLC–MS/MS method and its applications to drug residue and pharmacokinetic study. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 985, 124–130.
Simultaneous quantitative determination of sanguinarine, chelerythrine, dihydrosanguinarine and dihydrochelerythrine in chicken by HPLC–MS/MS method and its applications to drug residue and pharmacokinetic study.Crossref | GoogleScholarGoogle Scholar | 25681643PubMed |

Yang S, Lian G (2020) ROS and diseases: role in metabolism and energy supply. Molecular and Cellular Biochemistry 467, 1–12.
ROS and diseases: role in metabolism and energy supply.Crossref | GoogleScholarGoogle Scholar | 31813106PubMed |

Zdařilová A, Vrzal R, Rypka M, Ulrichová J, Dvorák Z (2006) Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells. Food and Chemical Toxicology 44, 242–249.
Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells.Crossref | GoogleScholarGoogle Scholar | 16115718PubMed |

Zhang H-H, Wu Y, Sun Z-L, Liu Z-Y (2013a) Identification of sanguinarine metabolites in pig liver preparations by accurate mass measurements using electrospray ionization hybrid ion trap/time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry 27, 979–984.
Identification of sanguinarine metabolites in pig liver preparations by accurate mass measurements using electrospray ionization hybrid ion trap/time-of-flight mass spectrometry.Crossref | GoogleScholarGoogle Scholar | 23592200PubMed |

Zhang Y, Cui Y-L, Gao L-N, Jiang H-L (2013b) Effects of β-cyclodextrin on the intestinal absorption of berberine hydrochloride, a P-glycoprotein substrate. International Journal of Biological Macromolecules 59, 363–371.
Effects of β-cyclodextrin on the intestinal absorption of berberine hydrochloride, a P-glycoprotein substrate.Crossref | GoogleScholarGoogle Scholar | 23664937PubMed |

Zhang D-S, Liu Z-Y, Li Y-j, Sun Z-L (2014) NQO1 involves in the imine bond reduction of sanguinarine and recombinant adeno-associated virus mediated NQO1 overexpression decreases sanguinarine-induced cytotoxicity in rat BRL cells. Toxicology Letters 225, 119–129.
NQO1 involves in the imine bond reduction of sanguinarine and recombinant adeno-associated virus mediated NQO1 overexpression decreases sanguinarine-induced cytotoxicity in rat BRL cells.Crossref | GoogleScholarGoogle Scholar | 24300172PubMed |