Effect of a probiotic (Lactobacillus sp.), yeast (Saccharomyces cerevisiae) and mycotoxin detoxifier alone or in combination on performance, immune response and serum biochemical parameters in broilers fed deoxynivalenol-contaminated diets
Tayebe Azizi A , Mohsen Daneshyar
A C , Manoochehr Allymehr B , Amir Tukmechi B , Hamed Khalilvandi Behroozyar A and Ali Shalizar Jalali B
+ Author Affiliations
- Author Affiliations
A Department of Animal Science, Faculty of Agricultural Science, Urmia University, PO Box 165, Urmia, Iran.
B Faculty of Veterinary Medicine, Urmia University, PO Box 165, Urmia, Iran.
C Corresponding author. Email: Daneshyar_Mohsen@yahoo.com
Animal Production Science 61(15) 1553-1563 https://doi.org/10.1071/AN19728
Submitted: 29 December 2019 Accepted: 2 June 2021 Published: 8 July 2021
Abstract
Context: Deoxynivalenol (DON) contamination of feedstuffs causes detrimental effects on animals and poultry. Dietary inclusion of microbial feed additives, such as probiotics and/or yeast, seems to be a useful approach for DON detoxification and reducing the toxin absorption from the gut.
Aims: This study was conducted to evaluate the synergetic effects of a probiotic (Lactobacillus spp.), yeast (Saccharomyces cerevisiae) and mycotoxin detoxifier on performance, serum chemical parameters and immune status of broiler chickens fed a DON-contaminated diet.
Methods: A total of 200 1-day-old female broilers (Hubbard®) were allocated to five dietary treatments with four replicates each in a completely randomised design. Experimental diets consisted of: (1) control diet (basal diet), (2) DON diet (basal diet contaminated with 10 mg/kg DON), (3) DON diet supplemented with 0.25% mycotoxin detoxifier (Mycofix® Plus), (4) DON diet supplemented with a combination of 0.4 g/kg probiotic and 1.5 g/kg yeast, and (5) DON diet supplemented with a combination of a probiotic, yeast and mycotoxin detoxifier.
Key results: The results showed that the DON diet significantly increased the feed conversion ratio compared with mycotoxin detoxifier and control diets. Administration of 0.4 g/kg probiotic along with 1.5 g/kg yeast to a DON-contaminated diet caused a significant enhancement of dressing percentage, leg relative weight and aspartate aminotransferase enzyme activity. The DON-contaminated diet reduced total protein, albumin, triglyceride and cholesterol concentrations, but consumption of a probiotic, yeast and mycotoxin detoxifier improved the levels of these parameters. The DON-treated birds showed a reduction in haematocrit, haemoglobin, red blood cells and blood lymphocyte percentage in comparison with control levels. The inclusion of a combination of a probiotic and yeast along with mycotoxin detoxifier diminished the increased heterophil: lymphocyte ratio by DON administration. The antibody titre against Newcastle disease virus vaccine increased by inclusion of a probiotic, yeast and Mycofix.
Conclusions: In summary, a combination of a probiotic and yeast along with mycotoxin detoxifier can improve the enzyme activity, immunity and haematological attributes, which are useful for DON-contaminated diet detoxification.
Implications: Dietary supplementation with a probiotic, yeast and mycotoxin detoxifier could be used as an alternative to detoxification DON in broiler chickens.
Keywords: enzymes activity, heterophil, Lactobacillus sp., lymphocyte, Newcastle disease virus titre, yeast.
References
Aravind KL, Patil VS, Devegowda G, Umakantha B, Ganpule SP (2003) Efficacy of esterified glucomannan to counteract mycotoxicosis in naturally contaminated feed on performance and serum biochemical and hematological parameters in broilers. Poultry Science 82, 571–576.| Efficacy of esterified glucomannan to counteract mycotoxicosis in naturally contaminated feed on performance and serum biochemical and hematological parameters in broilers.Crossref | GoogleScholarGoogle Scholar | 12710475PubMed |
Arif M, Iram A, Bhutta MA, Naiel MA, El-Hack A, Mohamed E, Othman SI, Allam AA, Am MS, Taha AE (2020) The Biodegradation Role of Saccharomyces cerevisiae against Harmful Effects of Mycotoxin Contaminated Diets on Broiler Performance, Immunity Status, and Carcass characteristics. Animals (Basel) 10, 238
| The Biodegradation Role of Saccharomyces cerevisiae against Harmful Effects of Mycotoxin Contaminated Diets on Broiler Performance, Immunity Status, and Carcass characteristics.Crossref | GoogleScholarGoogle Scholar |
Arshad N, Neubauer C, Hasnain S, Hess M (2008) Peganum harmala can minimize Escherichia coli infection in poultry, but long-term feeding may induce side effects. Poultry Science 87, 240–249.
| Peganum harmala can minimize Escherichia coli infection in poultry, but long-term feeding may induce side effects.Crossref | GoogleScholarGoogle Scholar | 18212366PubMed |
Ashayerizadeh O, Dastar B, Samadi F, Khomeiri M, Yamchi A, Zerehdaran S (2016) Effects of lactobacillus-based probiotic on performance, gut microflora, hematology and intestinal morphology in young broiler chickens challenged with Salmonella Typhimurium. Poultry Science Journal 4, 157–165.
| Effects of lactobacillus-based probiotic on performance, gut microflora, hematology and intestinal morphology in young broiler chickens challenged with Salmonella Typhimurium.Crossref | GoogleScholarGoogle Scholar |
Awad WA, Böhm J, Razzazi-Fazeli E, Hulan HW, Zentek J (2004) Effects of deoxynivalenol on general performance and electrophysiological properties of intestinal mucosa of broiler chickens. Poultry Science 83, 1964–1972.
| Effects of deoxynivalenol on general performance and electrophysiological properties of intestinal mucosa of broiler chickens.Crossref | GoogleScholarGoogle Scholar | 15615008PubMed |
Awad WA, Böhm J, Razzazi-Fazeli E, Ghareeb K, Zentek J (2006a) Effect of addition of a probiotic microorganism to broiler diets contaminated with deoxynivalenol on performance and histological alterations of intestinal villi of broiler chickens. Poultry Science 85, 974–979.
| Effect of addition of a probiotic microorganism to broiler diets contaminated with deoxynivalenol on performance and histological alterations of intestinal villi of broiler chickens.Crossref | GoogleScholarGoogle Scholar | 16776464PubMed |
Awad WA, Böhm J, Razzazi‐Fazeli E, Zentek J (2006b) Effects of feeding deoxynivalenol contaminated wheat on growth performance, organ weights and histological parameters of the intestine of broiler chickens. Journal of Animal Physiology and Animal Nutrition 90, 32–37.
| Effects of feeding deoxynivalenol contaminated wheat on growth performance, organ weights and histological parameters of the intestine of broiler chickens. Crossref | GoogleScholarGoogle Scholar | 16422767PubMed |
Awad WA, Ghareeb K, Böhm J, Zentek J (2010) Decontamination and detoxification strategies for the Fusarium mycotoxin deoxynivalenol in animal feed and the effectiveness of microbial biodegradation. Food Additives and Contaminants 27, 510–520.
| Decontamination and detoxification strategies for the Fusarium mycotoxin deoxynivalenol in animal feed and the effectiveness of microbial biodegradation.Crossref | GoogleScholarGoogle Scholar | 20234966PubMed |
Awad WA, Ghareeb K, Dadak A, Gille L, Staniek K, Hess M, Böhm J (2012) Genotoxic effects of deoxynivalenol in broiler chickens fed low-protein feeds. Poultry Science 91, 550–555.
| Genotoxic effects of deoxynivalenol in broiler chickens fed low-protein feeds.Crossref | GoogleScholarGoogle Scholar | 22334729PubMed |
Azizi T, Daneshyar M, Allymehr M, Tukmechi A, Khalilvandi Behroozyar H, Shalizar Jalali A (2021) Combination of Lactobacillus species and yeast ameliorates adverse effect of deoxynivalenol contaminated diet on immune system, gut morphology and jejunal gene expression in broiler chickens. Italian Journal of Animal Science 20, 59–70.
| Combination of Lactobacillus species and yeast ameliorates adverse effect of deoxynivalenol contaminated diet on immune system, gut morphology and jejunal gene expression in broiler chickens.Crossref | GoogleScholarGoogle Scholar |
Bagherzadeh Kasmani F, Karimi Torshizi MA, Allameh A, Shariatmadari F (2012) A novel aflatoxin-binding Bacillus probiotic: Performance, serum biochemistry, and immunological parameters in Japanese quail. Poultry Science 91, 1846–1853.
| A novel aflatoxin-binding Bacillus probiotic: Performance, serum biochemistry, and immunological parameters in Japanese quail.Crossref | GoogleScholarGoogle Scholar | 22802177PubMed |
Binder EM, Heidler D, Schatzmayr G, Thimm N, Fuchs E, Schuh M, Binder J (2000) Microbial detoxification of mycotoxins in animal feed. Mycotoxins and phycotoxins in perspective at the turn of the millennium. In ‘Proceedings of the 10th international IUPAC symposium, mycotoxins and phycotoxins’, Brazil -May 20–25.pp. 271-277
Boudergue C, Burel C, Dragacci S, Favrot MC, Fremy JM, Massimi C, Morgavi D (2009) Review of mycotoxin‐detoxifying agents used as feed additives: mode of action, efficacy and feed/food safety. EFSA Supporting Publications 6, 22E
| Review of mycotoxin‐detoxifying agents used as feed additives: mode of action, efficacy and feed/food safety.Crossref | GoogleScholarGoogle Scholar |
Bovo F, Franco LT, Kobashigawa E, Rottinghaus GE, Ledoux DR, Oliveira CAF (2015) Efficacy of beer fermentation residue containing Saccharomyces cerevisiae cells for ameliorating aflatoxicosis in broilers. Poultry Science 94, 934–942.
| Efficacy of beer fermentation residue containing Saccharomyces cerevisiae cells for ameliorating aflatoxicosis in broilers.Crossref | GoogleScholarGoogle Scholar | 25743420PubMed |
Chowdhury SR, Smith TK, Boermans HJ, Sefton AE, Downey R, Woodward B (2005) Effects of feeding blends of grains naturally contaminated with Fusarium mycotoxins on performance, metabolism, hematology, and immune competence of ducklings. Poultry Science 84, 1179–1185.
| Effects of feeding blends of grains naturally contaminated with Fusarium mycotoxins on performance, metabolism, hematology, and immune competence of ducklings.Crossref | GoogleScholarGoogle Scholar | 16156200PubMed |
Danicke S, Ueberschar KH, Halle I, Matthes S, Valenta H, Flachowsky G (2002) Effect of addition of a detoxifying agent to laying hen diets containing uncontaminated or Fusarium toxin-contaminated maize on performance of hens and on carryover of zearalenone. Poultry Science 81, 1671–1680.
| Effect of addition of a detoxifying agent to laying hen diets containing uncontaminated or Fusarium toxin-contaminated maize on performance of hens and on carryover of zearalenone.Crossref | GoogleScholarGoogle Scholar | 12455595PubMed |
Faixová Z, Faix Š, Bořutová R, Leng Ľ (2010) Effects of feeding diets contaminated with Fusarium mycotoxins on blood biochemical parameters of broiler chickens. Acta Veterinaria Hungarica 58, 275–285.
| Effects of feeding diets contaminated with Fusarium mycotoxins on blood biochemical parameters of broiler chickens.Crossref | GoogleScholarGoogle Scholar | 20713319PubMed |
Galanis A, Kourkoutas Y, Tassou CC, Chorianopoulos N (2015) Detection and identification of probiotic Lactobacillus plantarum strains by multiplex PCR using RAPD-derived primers. International Journal of Molecular Sciences 16, 25141–25153.
| Detection and identification of probiotic Lactobacillus plantarum strains by multiplex PCR using RAPD-derived primers.Crossref | GoogleScholarGoogle Scholar | 26506345PubMed |
Ghareeb K, Awad WA, Böhm J (2012) Ameliorative effect of a microbial feed additive on infectious bronchitis virus antibody titer and stress index in broiler chicks fed deoxynivalenol. Poultry Science 91, 800–807.
| Ameliorative effect of a microbial feed additive on infectious bronchitis virus antibody titer and stress index in broiler chicks fed deoxynivalenol.Crossref | GoogleScholarGoogle Scholar | 22399717PubMed |
Ghareeb K, Awad WA, Sid-Ahmed OE, Böhm J (2014) Insights on the host stress, fear and growth responses to the deoxynivalenol feed contaminant in broiler chickens. PLoS One 9, e87727
| Insights on the host stress, fear and growth responses to the deoxynivalenol feed contaminant in broiler chickens.Crossref | GoogleScholarGoogle Scholar | 24498242PubMed |
Ghareeb K, Awad WA, Zebeli Q, Böhm J (2016) Deoxynivalenol in chicken feed alters the vaccinal immune response and clinical biochemical serum parameters but not the intestinal and carcass characteristics. Journal of Animal Physiology and Animal Nutrition 100, 53–60.
| Deoxynivalenol in chicken feed alters the vaccinal immune response and clinical biochemical serum parameters but not the intestinal and carcass characteristics.Crossref | GoogleScholarGoogle Scholar | 25900321PubMed |
Girish CK, Smith TK, Boermans HJ, Karrow NA (2008) Effects of feeding blends of grains naturally contaminated with Fusarium mycotoxins on performance, hematology, metabolism, and immunocompetence of turkeys. Poultry Science 87, 421–432.
| Effects of feeding blends of grains naturally contaminated with Fusarium mycotoxins on performance, hematology, metabolism, and immunocompetence of turkeys.Crossref | GoogleScholarGoogle Scholar | 18281567PubMed |
Hanif NQ, Muhammad G, Siddique M, Khanum A, Ahmed T, Gadahai JA, Kaukab G (2008) Clinico-pathomorphological, serum biochemical and histological studies in broilers fed ochratoxin A and a toxin deactivator (Mycofix® Plus). British Poultry Science 49, 632–642.
| Clinico-pathomorphological, serum biochemical and histological studies in broilers fed ochratoxin A and a toxin deactivator (Mycofix® Plus).Crossref | GoogleScholarGoogle Scholar | 18836911PubMed |
Hussein HS, Brasel JM (2001) Toxicity, metabolism, and impact of mycotoxins on humans and animals. Toxicology 167, 101–134.
| Toxicity, metabolism, and impact of mycotoxins on humans and animals.Crossref | GoogleScholarGoogle Scholar | 11567776PubMed |
Jard G, Liboz T, Mathieu F, Guyonvarc’h A, Lebrihi A (2011) Review of mycotoxin reduction in food and feed: from prevention in the field to detoxification by adsorption or transformation. Food Additives & Contaminants: Part A 28, 1590–1609.
| Review of mycotoxin reduction in food and feed: from prevention in the field to detoxification by adsorption or transformation.Crossref | GoogleScholarGoogle Scholar |
Jatmiko YD, Howarth GS, Barton MD (2017) Assessment of probiotic properties of lactic acid bacteria isolated from Indonesian naturally fermented milk. In ‘AIP Conference Proceedings’ (AIP Publishing: Melville, NY). 1908, 050008
Jiang SZ, Li Z, Wang GY, Yang ZB, Yang WR, Zhang GG, Wu YB (2014) Effects of Fusarium mycotoxins with yeast cell wall absorbent on hematology, serum biochemistry, and oxidative stress in broiler chickens. Journal of Applied Poultry Research 23, 165–173.
| Effects of Fusarium mycotoxins with yeast cell wall absorbent on hematology, serum biochemistry, and oxidative stress in broiler chickens.Crossref | GoogleScholarGoogle Scholar |
Kabak B, Dobson AD, Var IIL (2006) Strategies to prevent mycotoxin contamination of food and animal feed: a review. Critical Reviews in Food Science and Nutrition 46, 593–619.
| Strategies to prevent mycotoxin contamination of food and animal feed: a review.Crossref | GoogleScholarGoogle Scholar | 17092826PubMed |
Keller NP, Turner G, Bennett JW (2005) Fungal secondary metabolism—from biochemistry to genomics. Nature Reviews. Microbiology 3, 937–947.
| Fungal secondary metabolism—from biochemistry to genomics.Crossref | GoogleScholarGoogle Scholar | 16322742PubMed |
Kim PI, Jung MY, Chang YH, Kim S, Kim SJ, Park YH (2007) Probiotic properties of Lactobacillus and Bifidobacterium strains isolated from porcine gastrointestinal tract. Applied Microbiology and Biotechnology 74, 1103–1111.
| Probiotic properties of Lactobacillus and Bifidobacterium strains isolated from porcine gastrointestinal tract.Crossref | GoogleScholarGoogle Scholar | 17136367PubMed |
Kim E, Yang SM, Lim B, Park SH, Rackerby B, Kim HY (2020) Design of PCR assays to specifically detect and identify 37 Lactobacillus species in a single 96 well plate. BMC Microbiology 20, 96
| Design of PCR assays to specifically detect and identify 37 Lactobacillus species in a single 96 well plate.Crossref | GoogleScholarGoogle Scholar | 32295530PubMed |
Kirpich IA, Solovieva NV, Leikhter SN, Shidakova NA, Lebedeva OV, Sidorov PI, Bazhukova TA, Soloviev AG, Barve SS, McClain CJ, Cave M (2008) Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study. Alcohol 42, 675–682.
| Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study.Crossref | GoogleScholarGoogle Scholar | 19038698PubMed |
Kubena LF, Harvey RB, Corrier DE, Huff WE, Phillips TD (1987) Effects of feeding deoxynivalenol (DON, vomitoxin)-contaminated wheat to female White Leghorn chickens from day old through egg production. Poultry Science 66, 1612–1618.
| Effects of feeding deoxynivalenol (DON, vomitoxin)-contaminated wheat to female White Leghorn chickens from day old through egg production.Crossref | GoogleScholarGoogle Scholar | 3432188PubMed |
Kwiatkowska K, Winiarska-Mieczan A, Kwiecień M (2017) Feed additives regulating calcium homeostasis in the bones of poultry–a review. Annals of Animal Science 17, 303–316.
| Feed additives regulating calcium homeostasis in the bones of poultry–a review.Crossref | GoogleScholarGoogle Scholar |
Lala AO, Oso AO, Ajao AM, Idowu OM, Oni OO (2015) Effect of supplementation with molecular or nano-clay adsorbent on growth performance and haematological indices of starter and grower turkeys fed diets contaminated with varying dosages of aflatoxin B1. Livestock Science 178, 209–215.
| Effect of supplementation with molecular or nano-clay adsorbent on growth performance and haematological indices of starter and grower turkeys fed diets contaminated with varying dosages of aflatoxin B1.Crossref | GoogleScholarGoogle Scholar |
Lucke A, Doupovec B, Paulsen P, Zebeli Q, Böhm J (2017) Effects of low to moderate levels of deoxynivalenol on feed and water intake, weight gain, and slaughtering traits of broiler chickens. Mycotoxin Research 33, 261–271.
| Effects of low to moderate levels of deoxynivalenol on feed and water intake, weight gain, and slaughtering traits of broiler chickens.Crossref | GoogleScholarGoogle Scholar | 28687998PubMed |
Metzler-Zebeli BU, Lucke A, Doupovec B, Zebeli Q, Böhm J (2020) A multicomponent mycotoxin deactivator modifies the response of the jejunal mucosal and cecal bacterial community to deoxynivalenol contaminated feed and oral lipopolysaccharide challenge in chickens. Journal of Animal Science 98, skz377
| A multicomponent mycotoxin deactivator modifies the response of the jejunal mucosal and cecal bacterial community to deoxynivalenol contaminated feed and oral lipopolysaccharide challenge in chickens.Crossref | GoogleScholarGoogle Scholar | 32206780PubMed |
Oguz H, Kececi T, Birdane YO, Önder F, Kurtoglu V (2000) Effect of clinoptilolite on serum biochemical and haematological characters of broiler chickens during aflatoxicosis. Research in Veterinary Science 69, 89–93.
| Effect of clinoptilolite on serum biochemical and haematological characters of broiler chickens during aflatoxicosis.Crossref | GoogleScholarGoogle Scholar | 10924400PubMed |
Osselaere A, Santos R, Hautekiet V, De Backer P, Chiers K, Ducatelle R, Croubels S (2013) Deoxynivalenol impairs hepatic and intestinal gene expression of selected oxidative stress, tight junction and inflammation proteins in broiler chickens, but addition of an adsorbing agent shifts the effects to the distal parts of the small intestine. PLoS One 8, e69014
| Deoxynivalenol impairs hepatic and intestinal gene expression of selected oxidative stress, tight junction and inflammation proteins in broiler chickens, but addition of an adsorbing agent shifts the effects to the distal parts of the small intestine.Crossref | GoogleScholarGoogle Scholar | 23922676PubMed |
Peng X, Bai S, Ding X, Zeng Q, Zhang K, Fang J (2015) Pathological changes in the immune organs of broiler chickens fed on corn naturally contaminated with aflatoxins B1 and B2. Avian Pathology 44, 192–199.
| Pathological changes in the immune organs of broiler chickens fed on corn naturally contaminated with aflatoxins B1 and B2.Crossref | GoogleScholarGoogle Scholar | 25734871PubMed |
Peng Z, Chen L, Nüssler AK, Liu L, Yang W (2017) Current sights for mechanisms of deoxynivalenol‐induced hepatotoxicity and prospective views for future scientific research: A mini review. Journal of Applied Toxicology 37, 518–529.
| Current sights for mechanisms of deoxynivalenol‐induced hepatotoxicity and prospective views for future scientific research: A mini review.Crossref | GoogleScholarGoogle Scholar | 27996102PubMed |
Pizzolitto RP, Armando MR, Salvano MA, Dalcero AM, Rosa CA (2013) Evaluation of Saccharomyces cerevisiae as an anti aflatoxicogenic agent in broiler feedstuffs. Poultry Science 92, 1655–1663.
| Evaluation of Saccharomyces cerevisiae as an anti aflatoxicogenic agent in broiler feedstuffs.Crossref | GoogleScholarGoogle Scholar | 23687163PubMed |
Rashidi N, Khatibjoo A, Taherpour K, Akbari-Gharaei M, Shirzadi H (2020) Effects of licorice extract, probiotic, toxin binder and poultry litter biochar on performance, immune function, blood indices and liver histopathology of broilers exposed to aflatoxin-B1. Poultry Science 99, 5896–5906.
| Effects of licorice extract, probiotic, toxin binder and poultry litter biochar on performance, immune function, blood indices and liver histopathology of broilers exposed to aflatoxin-B1.Crossref | GoogleScholarGoogle Scholar | 33142507PubMed |
Seifi K, Karimi Torshizi MA, Rahimi S, Kazemifard M (2017) Efficiency of early, single-dose probiotic administration methods on performance, small intestinal morphology, blood biochemistry, and immune response of Japanese quail. Poultry Science 96, 2151–2158.
| Efficiency of early, single-dose probiotic administration methods on performance, small intestinal morphology, blood biochemistry, and immune response of Japanese quail.Crossref | GoogleScholarGoogle Scholar | 28521051PubMed |
Shang QH, Yang ZB, Yang WR, Li Z, Zhang GG, Jiang SZ (2016) Toxicity of Mycotoxins from Contaminated Corn with or without Yeast Cell Wall Adsorbent on Broiler Chickens. Asian-Australasian Journal of Animal Sciences 29, 674–680.
| Toxicity of Mycotoxins from Contaminated Corn with or without Yeast Cell Wall Adsorbent on Broiler Chickens.Crossref | GoogleScholarGoogle Scholar | 26954178PubMed |
Solis-Cruz B, Hernandez-Patlan D, Petrone VM, Pontin KP, Latorre JD, Beyssac E, Hernandez-Velasco X, Merino-Guzman R, Owens C, Hargis BM, Lopez-Arellano R (2019) Evaluation of Cellulosic Polymers and Curcumin to Reduce Aflatoxin B1 Toxic Effects on Performance, Biochemical, and Immunological Parameters of Broiler Chickens. Toxins 11, 121–140.
| Evaluation of Cellulosic Polymers and Curcumin to Reduce Aflatoxin B1 Toxic Effects on Performance, Biochemical, and Immunological Parameters of Broiler Chickens.Crossref | GoogleScholarGoogle Scholar |
Streit E, Naehrer K, Rodrigues I, Schatzmayr G (2013) Mycotoxin occurrence in feed and feed raw materials worldwide: long‐term analysis with special focus on Europe and Asia. Journal of the Science of Food and Agriculture 93, 2892–2899.
| Mycotoxin occurrence in feed and feed raw materials worldwide: long‐term analysis with special focus on Europe and Asia.Crossref | GoogleScholarGoogle Scholar | 23670211PubMed |
Succi M, Tremonte P, Reale A, Sorrentino E, Grazia L, Pacifico S, Coppola R (2005) Bile salt and acid tolerance of Lactobacillus rhamnosus strains isolated from Parmigiano Reggiano cheese. FEMS Microbiology Letters 244, 129–137.
| Bile salt and acid tolerance of Lactobacillus rhamnosus strains isolated from Parmigiano Reggiano cheese.Crossref | GoogleScholarGoogle Scholar | 15727832PubMed |
Swamy HVLN, Smith TK, MacDonald EJ, Boermans HJ, Squires EJ (2002) Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on swine performance, brain regional neurochemistry, and serum chemistry and the efficacy of a polymeric glucomannan mycotoxin adsorbent. Journal of Animal Science 80, 3257–3267.
| Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on swine performance, brain regional neurochemistry, and serum chemistry and the efficacy of a polymeric glucomannan mycotoxin adsorbent.Crossref | GoogleScholarGoogle Scholar |
Swamy HVLN, Smith TK, Karrow NA, Boermans HJ (2004) Effects of feeding blends of grains naturally contaminated with Fusarium mycotoxins on growth and immunological parameters of broiler chickens. Poultry Science 83, 533–543.
| Effects of feeding blends of grains naturally contaminated with Fusarium mycotoxins on growth and immunological parameters of broiler chickens.Crossref | GoogleScholarGoogle Scholar |
Weaver A, See M, Kim S (2014) Protective effect of two yeast based feed additives on pigs chronically exposed to deoxynivalenol and zearalenone. Toxins 6, 3336–3353.
| Protective effect of two yeast based feed additives on pigs chronically exposed to deoxynivalenol and zearalenone.Crossref | GoogleScholarGoogle Scholar | 25533517PubMed |
Wu S, Liu Y, Duan Y, Wang F, Guo F, Yan F, Yang X, Yang X (2018) Intestinal toxicity of deoxynivalenol is limited by supplementation with Lactobacillus plantarum JM113 and consequentially altered gut microbiota in broiler chickens. Journal of Animal Science and Biotechnology 9, 74
| Intestinal toxicity of deoxynivalenol is limited by supplementation with Lactobacillus plantarum JM113 and consequentially altered gut microbiota in broiler chickens.Crossref | GoogleScholarGoogle Scholar | 30338065PubMed |
Xu L, Eicher SD, Applegate TJ (2011) Effects of increasing dietary concentrations of corn naturally contaminated with deoxynivalenol on broiler and turkey poult performance and response to lipopolysaccharide. Poultry Science 90, 2766–2774.
| Effects of increasing dietary concentrations of corn naturally contaminated with deoxynivalenol on broiler and turkey poult performance and response to lipopolysaccharide.Crossref | GoogleScholarGoogle Scholar | 22080015PubMed |
Yang X, Li L, Duan Y, Yang X (2017) Antioxidant activity of Lactobacillus plantarum JM113 in vitro and its protective effect on broiler chickens challenged with deoxynivalenol. Journal of Animal Science 95, 837–846.
| Antioxidant activity of Lactobacillus plantarum JM113 in vitro and its protective effect on broiler chickens challenged with deoxynivalenol.Crossref | GoogleScholarGoogle Scholar | 28380583PubMed |
Yang X, Liang S, Guo F, Ren Z, Yang X, Long F (2020) Gut microbiota mediates the protective role of Lactobacillus plantarum in ameliorating deoxynivalenol-induced apoptosis and intestinal inflammation of broiler chickens. Poultry Science 99, 2395–2406.
| Gut microbiota mediates the protective role of Lactobacillus plantarum in ameliorating deoxynivalenol-induced apoptosis and intestinal inflammation of broiler chickens.Crossref | GoogleScholarGoogle Scholar | 32359574PubMed |
Yunus AW, Ghareeb K, Twaruzek M, Grajewski J, Böhm J (2012) Deoxynivalenol as a contaminant of broiler feed: effects on bird performance and response to common vaccines. Poultry Science 91, 844–851.
| Deoxynivalenol as a contaminant of broiler feed: effects on bird performance and response to common vaccines.Crossref | GoogleScholarGoogle Scholar | 22399723PubMed |
