Bovine STAT5A gene polymorphism and its influence on growth traits in Podolica breed
Maria Selvaggi A C , Angela Gabriella D’Alessandro B and Cataldo Dario A
+ Author Affiliations
- Author Affiliations
A Department of DETO, Section of Veterinary Science and Animal Production, University of Bari ‘Aldo Moro’, Valenzano 70010, Italy.
B Department of Agro-Environmental and Territorial Sciences, University of Bari ‘Aldo Moro’, Bari, Italy.
C Corresponding author. Email: maria.selvaggi@uniba.it
Animal Production Science 56(7) 1056-1060 https://doi.org/10.1071/AN14739
Submitted: 5 August 2014 Accepted: 10 November 2014 Published: 19 February 2015
Abstract
Signal transducers and activators of transcription (STAT) are latent cytoplasmic transcription factors that mediate the actions of a variety of peptide hormones and cytokines within target cells. STAT5A is the main mediator of growth hormone action on target genes and plays a key role as intracellular mediator of prolactin signalling. In this study, the T→C nucleotide polymorphism at position 12 743 in exon 16 of the bovine STAT5A gene was investigated with polymerase chain reaction-restriction fragment length polymorphism in a sample of Podolica young bulls. The Podolica breed derives from Bos primigenius podolicus (forebears of the modern Bos taurus), it has been present in Italy for a very long time and represents yet another example of successful biological adaptation to a hostile environment. The aims of this study were to estimate the allele and genotype frequencies in Podolica breed and to investigate a possible relationship between this polymorphism and some growth performance traits. The observed frequencies of C and T alleles were 0.344 and 0.656, respectively. The TT genotype was the most frequent in the studied population followed by TC and CC ones. Moreover, the animals carrying TT genotypes seem to show an initial faster growth, which determined higher bodyweight at 90 and 270 days of age; conversely, CC individuals exhibit a faster growth in the post-weaning period achieving the higher bodyweight at 450 days of age.
Additional keywords: gene polymorphism, growth traits, Podolica breed, STAT5A.
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