Micro-encapsulated sodium butyrate attenuates oxidative stress induced by corticosterone exposure and modulates apoptosis in intestinal mucosa of broiler chickens
Y. Jiang A B D , W. H. Zhang A D , F. Gao A C and G. H. Zhou A
+ Author Affiliations
- Author Affiliations
A Key Laboratory of Animal Origin Food Production and Safety Guarantee, Jiangsu Province; College of Animal Science and Technology; Synergetic Innovation Centre of Food Safety and Nutrition, Nanjing Agricultural University, Nanjing 210095, People’s Republic of China.
B Ginling College, Nanjing Normal University, Nanjing 210097, People’s Republic of China.
C Corresponding author. Email: gaofeng0629@sina.com
D These authors contributed equally to this work.
Animal Production Science 55(5) 587-594 https://doi.org/10.1071/AN13348
Submitted: 20 August 2013 Accepted: 7 March 2014 Published: 15 May 2014
Abstract
The aim of the present study was to investigate the effects of micro-encapsulated sodium butyrate (MSB) on oxidative stress and apoptosis induced by dietary corticosterone (CORT) in the intestinal mucosa of broiler chickens. In total, 120 1-day-old male broilers (Arbor Acres) were randomly allocated to two treatment groups and were fed on a control diet (without MSB) or 0.4 g MSB/kg diet. Each treatment had six replicates with five chickens each. From 7 days of age onward, 50% of the chickens in each dietary treatment were subjected to CORT treatment (30 mg/kg of diet). The experimental period was 21 days. The results showed that CORT administration decreased (P < 0.001) feed intake and bodyweight gain and increased (P < 0.001) feed to gain ratio (F : G) of broiler chickens. The dietary MSB supplementation decreased (P < 0.01) F : G and there was an interaction between MSB and CORT on F : G (P < 0.05). Moreover, the activities of superoxide dismutase, glutathione peroxidase and catalase in intestinal mucosa were decreased (P < 0.01 or P < 0.001), and the concentrations of malondialdehyde in the intestinal mucosa were elevated (P < 0.01) by CORT administration. In contrast, treatment of MSB increased (P < 0.01) the catalase activities in duodenal and jejunal mucosa and decreased (P < 0.01) the malondialdehyde concentrations in duodenal mucosa. Higher apoptosis index and lower mRNA expressions of bcl-2 in intestinal epithelial cells were induced (P < 0.05) by CORT treatment. However, MSB decreased (P < 0.05) the apoptosis index and increased the bcl-2 expression. These results suggest that dietary MSB can partially attenuate oxidative stress induced by CORT treatment and inhibit apoptosis of intestinal epithelial cells in broiler chickens.
References
Abrahamse SL, Pool-Zobel BL, Rechkemmer G (1999) Potential of short chain fatty acids to modulate the induction of DNA damage and changes in the intracellular calcium concentration by oxidative stress in isolated rat distal colon cells. Carcinogenesis 20, 629–634.| Potential of short chain fatty acids to modulate the induction of DNA damage and changes in the intracellular calcium concentration by oxidative stress in isolated rat distal colon cells.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1MXis1Crtb8%3D&md5=73f9d0e781f3b9b112c382ad6cca6741CAS | 10223191PubMed |
Chen W, Fu XB, Ge SL, Sun TZ, Zhou G, Han B, Du YR, Li HH, Sheng ZY (2005) Intravenous acid fibroblast growth factor protects intestinal mucosal cells against ischemia-reperfusion injury via regulating Bcl-2/Bax expression. World Journal of Gastroenterology 11, 3419–3425.
Chirakkal H, Leech SH, Brookes KE, Prais AL, Waby JS, Corfe BM (2006) Upregulation of BAK by butyrate in the colon is associated with increased Sp3 binding. Oncogene 25, 7192–7200.
| Upregulation of BAK by butyrate in the colon is associated with increased Sp3 binding.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28Xht1SrtbrE&md5=43d146fa074369953d3b4d46ce55edecCAS | 16732318PubMed |
Claus R, Lösel D, Lacorn M, Mentschel J, Schenkel H (2003) Effects of butyrate on apoptosis in the pig colon and its consequences for skatole formation and tissue accumulation. Journal of Animal Science 81, 239–248.
Claus R, Günthner D, Letzguß H (2007) Effects of feeding fat-coated butyrate on mucosal morphology and function in the small intestine of the pig. Journal of Animal Physiology and Animal Nutrition 91, 312–318.
| Effects of feeding fat-coated butyrate on mucosal morphology and function in the small intestine of the pig.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXpsFaju7o%3D&md5=eea0ad25ef498544a7cc72557678229fCAS | 17615002PubMed |
Covasa M, Forbes JM (1995) Selection of foods by broiler chickens following corticosterone administration. British Poultry Science 36, 489–501.
| Selection of foods by broiler chickens following corticosterone administration.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2MXnsVemt7s%3D&md5=28814f8043624e1be5c97e6f6576d5f6CAS | 7583379PubMed |
Donohoe DR, Collins LB, Wali A, Bigler R, Sun W, Bultman SJ (2012) The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. Molecular Cell 48, 612–626.
| The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhsV2qtLvK&md5=4d65e62bb868e4e03300667c56047310CAS | 23063526PubMed |
Friedel D, Levine GM (1992) Effect of short-chain fatty acids on colonic function and structure. Journal of Parenteral Enteral Nutrition 16, 1–4.
| Effect of short-chain fatty acids on colonic function and structure.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK387kvV2rsw%3D%3D&md5=6bfcc616f608bfaa82fcad58ed2792beCAS | 1738211PubMed |
Furuse M, Yang SI, Niwa N, Okumura J (1991) Effect of short chain fatty acids on the performance and intestinal weight in germ-free and conventional chicks. British Poultry Science 32, 159–165.
| Effect of short chain fatty acids on the performance and intestinal weight in germ-free and conventional chicks.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK3MXmslyksrs%3D&md5=ba173d0ce3940c8bcb1acf756f657b83CAS | 2049620PubMed |
Gálfi P, Neogrády S (2001) The pH-dependent inhibitory action of n-butyrate on gastrointestinal epithelial cell division. Food Research International 34, 581–586.
| The pH-dependent inhibitory action of n-butyrate on gastrointestinal epithelial cell division.Crossref | GoogleScholarGoogle Scholar |
Gao HB, Tong MH, Hu YQ, Guo QS, Ge R, Hardy MP (2002) Glucocorticoid induces apoptosis in rat Leydig cells. Endocrinology 143, 130–138.
| Glucocorticoid induces apoptosis in rat Leydig cells.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XjtVOrtQ%3D%3D&md5=7a5e06258a9103295aae1a5423952705CAS | 11751601PubMed |
Gruber J, Sgonc R, Hu YH, Beug H, Wick G (1994) Thymocyte apoptosis induced by elevated endogenous corticosterone levels. European Journal of Immunology 24, 1115–1121.
| Thymocyte apoptosis induced by elevated endogenous corticosterone levels.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2cXktVOhsLo%3D&md5=af8daf22cf6ec1eb9498c5b50753c0a7CAS | 8181522PubMed |
Hall ME, Blount JD, Forbes S, Royle NJ (2010) Does oxidative stress mediate the trade-off between growth and selfmaintenance in structured families? Functional Ecology 24, 365–373.
| Does oxidative stress mediate the trade-off between growth and selfmaintenance in structured families?Crossref | GoogleScholarGoogle Scholar |
Halliwell BH, Gutteridge JMC (Eds) (2007) ‘Free radicals in biology and medicine.’ 4th edn. (Oxford University Press: Oxford, UK)
Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ, Brummer RJ (2008) Review article: the role of butyrate on colonic function. Alimentary Pharmacology & Therapeutics 27, 104–119.
| Review article: the role of butyrate on colonic function.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXitVKrsbo%3D&md5=1b0a065c7e7c7f0f85a6c0cda8937fa5CAS |
Hamer HM, Jonkers DM, Bast A, Vanhoutvin SA, Fischer MA, Kodde A, Troost FJ, Venema K, Brummer RJ (2009) Butyrate modulates oxidative stress in the colonic mucosa of healthy humans. Clinical Nutrition 28, 88–93.
| Butyrate modulates oxidative stress in the colonic mucosa of healthy humans.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhs1arsb0%3D&md5=7d18b42964376d7680f088d7dc033b43CAS | 19108937PubMed |
Harris CC (1996) The p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology and cancer risk assessment. Environmental Health Perspectives 104, 435–439.
Hass R, Busche R, Luciano L, Reale E, Engelhardt WV (1997) Lack of butyrate is associated with induction of Bax and subsequent apoptosis in the proximal colon of guinea pig. Gastroenterology 112, 875–881.
| Lack of butyrate is associated with induction of Bax and subsequent apoptosis in the proximal colon of guinea pig.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2sXhvFOls7c%3D&md5=1aaab2c7c7171587c0b0cd14e944205bCAS | 9041249PubMed |
Heerdt BG, Houston MA, Augenlicht LH (1994) Potentiation by specific short chain fatty acids of differentiation and apoptosis in human colonic carcinoma cell lines. Cancer Research 54, 3288–3293.
Hu ZH, Guo YM (2007) Effects of dietary sodium butyrate supplementation on the intestinal morphological structure, absorptive function and gut flora in chickens. Animal Feed Science and Technology 132, 240–249.
| Effects of dietary sodium butyrate supplementation on the intestinal morphological structure, absorptive function and gut flora in chickens.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28Xht1eqtrjP&md5=02006d8290ac396dc2ec4b63f4c9d5d0CAS |
Hu XF, Guo YM (2008) Corticosterone administration alters small intestinal morphology and function of broiler chickens. Asian-Australasian Journal of Animal Sciences 21, 1773–1778.
Hu W (2007) Effect of sodium butyrate on the apoptosis of colonic epithelial cells. Medical Journal of Wuhan University 28, 468–470. [In Chinese]
Kannan K, Jain SK (2000) Oxidative stress and apoptosis. Pathophysiology 7, 153–163.
| Oxidative stress and apoptosis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXntFOntrw%3D&md5=7c570667da040c027aee2bd9c50466ebCAS | 10996508PubMed |
Kassahn KS, Crozier RH, Pörtner HO, Caley MJ (2009) Animal performance and stress: responses and tolerance limits at different levels of biological organisation. Biological Reviews of the Cambridge Philosophical Society 84, 277–292.
| Animal performance and stress: responses and tolerance limits at different levels of biological organisation.Crossref | GoogleScholarGoogle Scholar | 19344429PubMed |
Ko LJ, Prives C (1996) p53: puzzle and paradigm. Genes & Development 10, 1054–1072.
| p53: puzzle and paradigm.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK28XjtFajtbs%3D&md5=820a046f3c4d0584ef912ddf00464fc1CAS |
Le Gall M, Gallois M, Seve B, Louveau I, Holst JJ, Oswald IP, Lalles JP, Guilloteau P (2009) Comparative effect of orally administered sodium butyrate before or after weaning on growth and several indices of gastrointestinal biology of piglets. The British Journal of Nutrition 102, 1285–1296.
| Comparative effect of orally administered sodium butyrate before or after weaning on growth and several indices of gastrointestinal biology of piglets.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhsVyrtLzO&md5=340a8e47a1fb52e07abb57358b1d29eeCAS | 19480733PubMed |
Lin H, Decuypere E, Buyse J (2004) Oxidative stress induced by corticosterone administration in broiler chickens (Gallus gallus domesticus): 1. Chronic exposure. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 139, 737–744.
| Oxidative stress induced by corticosterone administration in broiler chickens (Gallus gallus domesticus): 1. Chronic exposure.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD2M%2FktFequg%3D%3D&md5=6a210edd36a2119bb4a1aa474846d68fCAS |
Ling YH, Liebes L, Zhou YY, Perez-Soler R (2003) Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. The Journal of Biological Chemistry 278, 33 714–33 723.
| Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXmvVCrt7s%3D&md5=96ae92638dd89715cb8d6c13c2f35f63CAS |
Luciano L, Gross S, Busche R, Engelhardt WV, Reale E (2002) Massive apoptosis of colonocytes induced by butyrate deprivation overloads resident macrophages and promotes the recruitment of circulating monocytes. Cell and Tissue Research 309, 393–407.
| Massive apoptosis of colonocytes induced by butyrate deprivation overloads resident macrophages and promotes the recruitment of circulating monocytes.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XmsVChurc%3D&md5=0e5aa168d95cc9999c7731a66b3496a7CAS | 12195296PubMed |
Lupton JR (2004) Microbial degradation products influence colon cancer risk: the butyrate controversy. The Journal of Nutrition 134, 479–482.
Malheiros RD, Moraes VMB, Collin A, Decuypere E, Buyse J (2003) Free diet selection by broilers as influenced by dietary macronutrient ratio and corticosterone supplementation: 1. Diet selection, organ weights, and plasma metabolites. Poultry Science 82, 123–131.
| Free diet selection by broilers as influenced by dietary macronutrient ratio and corticosterone supplementation: 1. Diet selection, organ weights, and plasma metabolites.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXht1yjt78%3D&md5=e6499bcc3882aff736888f43f7c7d88eCAS | 12580254PubMed |
Mandal M, Wu X, Kumar R (1997) Bcl-2 deregulation leads to inhibition of sodium butyrate-induced apoptosis in human colorectal carcinoma cells. Carcinogenesis 18, 229–232.
| Bcl-2 deregulation leads to inhibition of sodium butyrate-induced apoptosis in human colorectal carcinoma cells.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2sXhs1Kksbg%3D&md5=abf99996ecfa008e5991dac55f5f5f82CAS | 9054611PubMed |
Maurice D, Lightsey SF, Toler JE, Canty S (2007) Effect of chronic oxidative/corticosterone-induced stress on ascorbic acid metabolism and total antioxidant capacity in chickens (Gallus gallus domesticus). Journal of Animal Physiology and Animal Nutrition 91, 355–360.
| Effect of chronic oxidative/corticosterone-induced stress on ascorbic acid metabolism and total antioxidant capacity in chickens (Gallus gallus domesticus).Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXpsFaisro%3D&md5=27db922af336e261d57a27e495972a60CAS | 17615008PubMed |
Melov S (2002) Animal models of oxidative stress, aging, and therapeutic antioxidant interventions. The International Journal of Biochemistry & Cell Biology 34, 1395–1400.
| Animal models of oxidative stress, aging, and therapeutic antioxidant interventions.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XmsVersbk%3D&md5=1c1a0bc2d0dd916230ddbc41a555a3f0CAS |
Mentschel J, Claus R (2003) Increased butyrate formation in the pig colon by feeding raw potato starch leads to a reduction of colonocyte apoptosis and a shift to the stem cell compartment. Metabolism: Clinical and Experimental 52, 1400–1405.
| Increased butyrate formation in the pig colon by feeding raw potato starch leads to a reduction of colonocyte apoptosis and a shift to the stem cell compartment.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXosVynt7o%3D&md5=70ade377257399ce260e36e38ad99410CAS |
Mentschel J, Leiser R, Mülling C, Pfarrer C, Claus R (2001) Butyric acid stimulates rumen mucosa development in the calf mainly by a reduction of apoptosis. Archiv für Tierenährung 55, 85–102.
Musch MW, Walsh-Reitz MM, Chang EB (2006) Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption. American Journal of Physiology. Gastrointestinal and Liver Physiology 290, G222–G231.
| Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XhsFKht7g%3D&md5=63114990463638650d995b7611ac7340CAS | 16239402PubMed |
Nasir A, Moudgal RP, Singh NB (1999) Involvement of corticosterone in food intake, food passage time and in vivo uptake of nutrients in the chicken (Gallus domesticus). British Poultry Science 40, 517–522.
| Involvement of corticosterone in food intake, food passage time and in vivo uptake of nutrients in the chicken (Gallus domesticus).Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1MXnt1elu7g%3D&md5=14366a69c7dddab4de8ef06ce64f3d9bCAS | 10579411PubMed |
Nijdam E, Arens P, Lambooij E, Decuypere E, Stegeman JA (2004) Factors influencing bruises and mortality of broilers during catching, transport and lairage. Poultry Science 83, 1610–1615.
| Factors influencing bruises and mortality of broilers during catching, transport and lairage.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD2cvnsVWktw%3D%3D&md5=c89ad134780706828007a5a690eb9bc2CAS | 15384914PubMed |
Nijdam E, Delezie E, Lambooij E, Nabuurs MJ, Decuypere E, Stegeman JA (2005) Feed withdrawal of broilers before transport changes plasma hormone and metabolite concentration. Poultry Science 84, 1146–1152.
| Feed withdrawal of broilers before transport changes plasma hormone and metabolite concentration.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXmsVamtrs%3D&md5=35b33dde8114773b1cbf46cb19b998b6CAS | 16050132PubMed |
NRC (1994) ‘Nutrient requirements of poultry.’ 9th edn. (National Academy Press: Washington, DC)
Park JW, Ryter SW, Choi AM (2007) Functional significance of apoptosis in chronic obstructive pulmonary disease. COPD: Journal of Chronic Obstructive Pulmonary Disease 4, 347–353.
| Functional significance of apoptosis in chronic obstructive pulmonary disease.Crossref | GoogleScholarGoogle Scholar | 18027162PubMed |
Pei XY, Dai Y, Grant S (2004) Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors. Clinical Cancer Research 10, 3839–3852.
| Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXksVKnt7g%3D&md5=a54bbc739505f2113156bd6e3fc7091fCAS | 15173093PubMed |
Piva A, Morlacchini M, Casadei G, Gatta PP, Biagi G, Prandini A (2002) Sodium butyrate improves growth performance of weaned piglets during the first period after weaning. Italian Journal of Animal Science 1, 35–41.
Puvadolpirod S, Thaxton JP (2000) Model of physiological stress in chickens. 1. Response parameters. Poultry Science 79, 363–369.
| Model of physiological stress in chickens. 1. Response parameters.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXitVGjsro%3D&md5=e392331aa257fb4dd155f4ff149db1ebCAS | 10735203PubMed |
Rosignoli P, Fabiani R, De Bartolomeo A, Spinozzi1 F, Agea E, Pelli MA, Morozzi G (2001) Protective activity of butyrate on hydrogen peroxide-induced DNA damage in isolated human colonocytes and HT29 tumour cells. Carcinogenesis 22, 1675–1680.
| Protective activity of butyrate on hydrogen peroxide-induced DNA damage in isolated human colonocytes and HT29 tumour cells.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXnsFKmtLg%3D&md5=f0e2f831146c7b5c04f4a2becf266c60CAS | 11577008PubMed |
Sauer J, Richter KK, Pool-Zobel BL (2007) Physiological concentrations of butyrate favorably modulate genes of oxidative and metabolic stress in primary human colon cells. The Journal of Nutritional Biochemistry 18, 736–745.
| Physiological concentrations of butyrate favorably modulate genes of oxidative and metabolic stress in primary human colon cells.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXht1aksLfF&md5=1c9b443ba7a10128e0916b8dbdb4175fCAS | 17434725PubMed |
Schwartzman RA, Cidlowski JA (1993) Apoptosis: the biochemistry and molecular biology of programmed cell death. Endocrine Reviews 14, 133–151.
Siegel HS (1980) Physiological stress in birds. Bioscience 30, 529–534.
| Physiological stress in birds.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL3cXls1Cltrs%3D&md5=da15af384aec7f43fe98d85affa6c846CAS |
Siegel HS (1995) Stress, strains and resistance. British Poultry Science 36, 3–22.
| Stress, strains and resistance.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK2MzjvVOltA%3D%3D&md5=1ae00051cf70a2d4a162cd35beb6cf07CAS | 7614023PubMed |
Smulikowska S, Czerwiński J, Mieczkowska A, Jankowiak J (2009) The effect of fat-coated organic acid salts and a feed enzyme on growth performance, nutrient utilization, microflora activity, and morphology of the small intestine in broiler chickens. Journal of Animal and Feed Sciences 18, 478–489.
Song M, Xia B, Li J (2006) Effects of topical treatment of sodium butyrate and 5-aminosalicylic acid on expression of trefoil factor 3, interleukin 1β, and nuclear factor κB in trinitrobenzene sulphonic acid induced colitis in rats. Postgraduate Medical Journal 82, 130–135.
| Effects of topical treatment of sodium butyrate and 5-aminosalicylic acid on expression of trefoil factor 3, interleukin 1β, and nuclear factor κB in trinitrobenzene sulphonic acid induced colitis in rats.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28Xit1yru78%3D&md5=d3a9490c9de0a4c89335d96ef62e20f8CAS | 16461476PubMed |
Steinert M, Wobus M, Boltze C, Schütz A, Wahlbuhl M, Hamann J, Aust G (2002) Expression and regulation of CD97 in colorectal carcinoma cell lines and tumor tissues. American Journal of Pathology 161, 1657–1667.
| Expression and regulation of CD97 in colorectal carcinoma cell lines and tumor tissues.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XptV2gt7g%3D&md5=af7d020721b0840ea0f2b3ae618cf6ecCAS | 12414513PubMed |
The State Science and Technology Commission (1988) ‘Regulations for the administration of affairs concerning experimental animals.’ (The State Science and Technology Commission: Beijing, China)
Vanhoutvin SALW, Troost FJ, Hamer HM, Lindsey PJ, Koek GH, Jonkers DMAE, Kodde A, Venema K, Brummer RJM (2009) Butyrate-induced transcriptional changes in human colonic mucosa. PLoS ONE 4, e6759
| Butyrate-induced transcriptional changes in human colonic mucosa.Crossref | GoogleScholarGoogle Scholar |
Virden WS, Lilburn MS, Thaxton JP, Corzo A, Hoehler D, Kidd MT (2007) The effect of corticosterone-induced stress on amino acid digestibility in Ross broilers. Poultry Science 86, 338–342.
| The effect of corticosterone-induced stress on amino acid digestibility in Ross broilers.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXlvVSkurg%3D&md5=5492f68caabaa2b54a5bf39d4cc60b13CAS | 17234848PubMed |
Vousden KH (2000) p53: death star. Cell 103, 691–694.
| p53: death star.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXos1Snuro%3D&md5=a4da6d35ff54f01070387ae01d9ba1f1CAS | 11114324PubMed |
Wang YF, Chen NS, Chung YP, Chang LH, Chiou YH, Chen CY (2006) Sodium butyrate induces apoptosis and cell cycle arrest in primary effusion lymphoma cells independently of oxidative stress and p21CIP1/WAF1 induction. Molecular and Cellular Biochemistry 285, 51–59.
| Sodium butyrate induces apoptosis and cell cycle arrest in primary effusion lymphoma cells independently of oxidative stress and p21CIP1/WAF1 induction.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XjvFGiu74%3D&md5=1ae9117a63e06da14f6a63c18ee11e8eCAS | 16477379PubMed |
Yamamoto H, Fujimoto J, Okamoto E, Furuyama J, Tamaoki T, Hashimoto-Tamaoki T (1998) Suppression of growth of hepatocellular carcinoma by sodium butyrate in vitro and in vivo. International Journal of Cancer 76, 897–902.
| Suppression of growth of hepatocellular carcinoma by sodium butyrate in vitro and in vivo.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1cXjsFyqt7s%3D&md5=9e9579cb6e5edc0570742772e6c96ca6CAS |
Zhang L, Yue HY, Zhang HJ, Xu L, Wu SG, Yan HJ, Gong YS, Qi GH (2009) Transport stress in broilers: I. Blood metabolism, glycolytic potential, and meat quality. Poultry Science 88, 2033–2041.
| Transport stress in broilers: I. Blood metabolism, glycolytic potential, and meat quality.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXht1OgsbjP&md5=effb21599075b51b127aa35d29ac8de5CAS | 19762854PubMed |
Zhang WH, Gao F, Zhu QF, Li C, Jiang Y, Dai SF, Zhou GH (2011a) Dietary sodium butyrate alleviates the oxidative stress induced by corticosterone exposure and improves meat quality in broiler chickens. Poultry Science 90, 2592–2599.
| Dietary sodium butyrate alleviates the oxidative stress induced by corticosterone exposure and improves meat quality in broiler chickens.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhsV2hs73K&md5=e8c22d55888d7e6178b1edc53da40749CAS | 22010246PubMed |
Zhang WH, Jiang Y, Zhu QF, Gao F, Dai SF, Chen J, Zhou GH (2011b) Sodium butyrate maintains growth performance by regulating the immune response in broiler chickens. British Poultry Science 52, 292–301.
| Sodium butyrate maintains growth performance by regulating the immune response in broiler chickens.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXovVensrs%3D&md5=55ccd9d498f4ed284d789c306050d30cCAS | 21732874PubMed |
Zulkifli I, Al-Aqil A, Omar AR, Sazili AQ, Rajion MA (2009) Crating and heat stress influence blood parameters and heat shock protein 70 expression in broiler chickens showing short or long tonic immobility reactions. Poultry Science 88, 471–476.
| Crating and heat stress influence blood parameters and heat shock protein 70 expression in broiler chickens showing short or long tonic immobility reactions.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD1M7jsFOrug%3D%3D&md5=6008058389de20504407367acd26a094CAS | 19211514PubMed |
