Effect of 1,3,5,8-tetrahydroxyxanthone on carcass characteristics and meat quality traits in pigs
Hong-Bo Xiao A D , Fang Jun B and Zhi-Liang Sun C
+ Author Affiliations
- Author Affiliations
A College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.
B College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China.
C Biological Veterinary Drugs Branch, National Research Centre of Engineering and Technology for Utilisation of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China.
D Corresponding author. Email: xhbzhb@yahoo.com
Animal Production Science 52(11) 991-997 https://doi.org/10.1071/AN12001
Submitted: 26 October 2011 Accepted: 8 May 2012 Published: 16 July 2012
Abstract
Angiopoietin-like protein 3 (Angptl3) may promote adipose formation. The present study investigated the beneficial effect of 1,3,5,8-tetrahydroxyxanthone (Xan), a naturally occurring polyphenol agent, on carcass characteristics and meat quality in pigs and the mechanisms involved. Forty-eight Duroc × Landrace × Yorkshire pigs (65.3 ± 7.8 kg) were randomly divided into four groups: control group, untreated high lipid diet (HLD) group and two groups of HLD with Xan (1 or 3%). Forty-two days later, Xan (1 or 3%) treatment significantly increased percentage lean, loin eye area, colour, expression and activity of adipose tissue lipoprotein lipase activity and decreased percentage fat, backfat thickness, total cholesterol concentration, triglyceride concentration, and Angptl3 mRNA expression. The present results suggest that the beneficial effect of Xan on carcass characteristics and meat quality may be related to decreased expression of Angptl3 in pig.
References
Baba S, Natsume M, Yasuda A, Nakamura Y, Tamura T, Osakabe N, Kanegae M, Kondo K (2007) Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder. The Journal of Nutrition 137, 1436–1441.Casanovas A, Carrascal M, Abián J, López-Tejero MD, Llobera M (2009) Lipoprotein lipase is nitrated in vivo after lipopolysaccharide challenge. Free Radical Biology & Medicine 47, 1553–1560.
| Lipoprotein lipase is nitrated in vivo after lipopolysaccharide challenge.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhtlyrtbrE&md5=c8aa651cdd3946b298f7df88ed3e0afcCAS |
Chen Y, Zhu J, Lum PY, Yang X, Pinto S, MacNeil DJ, Zhang C, Lamb J, Edwards S, Sieberts SK, Leonardson A, Castellini LW, Wang S, Champy MF, Zhang B, Emilsson V, Doss S, Ghazalpour A, Horvath S, Drake TA, Lusis AJ, Schadt EE (2008) Variations in DNA elucidate molecular networks that cause disease. Nature 452, 429–435.
| Variations in DNA elucidate molecular networks that cause disease.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXjslCnurc%3D&md5=793903f0975d2f92f35a6825bb28010fCAS |
Corino C, Magni S, Pastorelli G, Rossi R, Mourot J (2003) Effect of conjugated linoleic acid on meat quality, lipid metabolism, and sensory characteristics of dry-cured hams from heavy pigs. Journal of Animal Science 81, 2219–2229.
Crawford SM, Moeller SJ, Zerby HN, Irvin KM, Kuber PS, Velleman SG, Leeds TD (2010) Effects of cooked temperature on pork tenderness and relationships among muscle physiology and pork quality traits in loins from Landrace and Berkshire swine. Meat Science 84, 607–612.
| Effects of cooked temperature on pork tenderness and relationships among muscle physiology and pork quality traits in loins from Landrace and Berkshire swine.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXit1ajsLw%3D&md5=448e2bfcfe3659abd21b9f3383f0e595CAS |
Ding XZ, Liang CN, Guo X, Xing CF, Bao PJ, Chu M, Pei J, Zhu XS, Yan P (2012) A novel single nucleotide polymorphism in exon 7 of LPL gene and its association with carcass traits and visceral fat deposition in yak (Bos grunniens) steers. Molecular Biology Reports 39, 669–673.
| A novel single nucleotide polymorphism in exon 7 of LPL gene and its association with carcass traits and visceral fat deposition in yak (Bos grunniens) steers.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhsFSju7vN&md5=c6fcda780b1451eec4a638c20ae86ffaCAS |
Eu CHA, Lim WYA, Ton SH, Kadir KA (2010) Glycyrrhizic acid improved lipoprotein lipase expression, insulin sensitivity, serum lipid and lipid deposition in high-fat diet-induced obese rats. Lipids in Health and Disease 9, 81
| Glycyrrhizic acid improved lipoprotein lipase expression, insulin sensitivity, serum lipid and lipid deposition in high-fat diet-induced obese rats.Crossref | GoogleScholarGoogle Scholar |
Feng SQ, Chen XD, Xia T, Gan L, Qiu H, Dai MH, Zhou L, Peng Y, Yang ZQ (2006) Cloning, chromosome mapping and expression characteristics of porcine ANGPTL3 and -4. Cytogenetic and Genome Research 114, 44–49.
| Cloning, chromosome mapping and expression characteristics of porcine ANGPTL3 and -4.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XkvVOitb4%3D&md5=50a37247406e8d53854ecbc31c8c9e14CAS |
Fujimoto K, Koishi R, Shimizugawa T, Ando Y (2006) Angptl3-null mice show low plasma lipid concentrations by enhanced lipoprotein lipase activity. Experimental Animals 55, 27–34.
| Angptl3-null mice show low plasma lipid concentrations by enhanced lipoprotein lipase activity.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XisFKmtb4%3D&md5=0c71027c750981261b330367ea514fb1CAS |
Huff MW, Telford DE, Edwards JY, Burnett JR, Barrett PH, Rapp SR, Napawan N, Keller BT (2002) Inhibition of the apical sodium-dependent bile acid transporter reduces LDL cholesterol and apoB by enhanced plasma clearance of LDL apoB. Arteriosclerosis, Thrombosis, and Vascular Biology 22, 1884–1891.
| Inhibition of the apical sodium-dependent bile acid transporter reduces LDL cholesterol and apoB by enhanced plasma clearance of LDL apoB.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38Xot1OitLs%3D&md5=a0f69ab19e878725c987a1f8dfaaa826CAS |
Jiang DJ, Jiang JL, Tan GS, Du YH, Xu KP, Li YJ (2003a) Protective effects of daviditin A against endothelial damage induced by lysophosphatidylcholine. Naunyn-Schmiedeberg’s Archives of Pharmacology 367, 600–606.
| Protective effects of daviditin A against endothelial damage induced by lysophosphatidylcholine.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXks1Oku7k%3D&md5=da8d15ebf4ac66e2fb47afb8f01c27b2CAS |
Jiang DJ, Hu GY, Jiang JL, Xiang HL, Deng HW, Li YJ (2003b) Relationship between protective effect of xanthone on endothelial cells and endogenous nitric oxide synthase inhibitors. Bioorganic & Medicinal Chemistry 11, 5171–5177.
| Relationship between protective effect of xanthone on endothelial cells and endogenous nitric oxide synthase inhibitors.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXos1Ohtbk%3D&md5=a45f3372f22cc91ebf7e0c1bf62b99bfCAS |
Jiang DJ, Jiang JL, Zhu HQ, Tan GS, Liu SQ, Xu KP, Li YJ (2004) Demethylbellidifolin preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level. Journal of Ethnopharmacology 93, 295–306.
| Demethylbellidifolin preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXltl2hs74%3D&md5=d0167654d88f538c307f26e12d7ec925CAS |
Jiang ZY, Jiang SQ, Lin YC, Xi PB, Yu DQ, Wu TX (2007) Effects of soybean isoflavone on growth performance, meat quality, and antioxidation in male broilers. Poultry Science 86, 1356–1362.
Kim DN, Lee KT, Reiner JM, Thomas WA (1974) Restraint of cholesterol accumulation in tissue pools associated with drastic short-term lowering of serum cholesterol levels by clofibrate or cholestyramine in hypercholesterolemic swine. Journal of Lipid Research 15, 326–331.
Köster A, Chao YB, Mosior M, Ford A, Gonzalez-DeWhitt PA, Hale JE, Li D, Qiu Y, Fraser CC, Yang DD, Heuer JG, Jaskunas SR, Eacho P (2005) Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Endocrinology 146, 4943–4950.
| Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism.Crossref | GoogleScholarGoogle Scholar |
Kouba M, Hermier D, Le Dividich J (2001) Influence of a high ambient temperature on lipid metabolism in the growing pig. Journal of Animal Science 79, 81–87.
Lahucky R, Nuernberg K, Kovac L, Bucko O, Nuernberg G (2010) Assessment of the antioxidant potential of selected plant extracts – in vitro and in vivo experiments on pork. Meat Science 85, 779–784.
| Assessment of the antioxidant potential of selected plant extracts – in vitro and in vivo experiments on pork.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXmslSqs70%3D&md5=5f019333f17f1f54cf2cf319f522b015CAS |
Luci S, Giemsa B, Kluge H, Eder K (2007) Clofibrate causes an upregulation of PPAR-α target genes but does not alter expression of SREBP target genes in liver and adipose tissue of pigs. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 293, R70–R77.
| Clofibrate causes an upregulation of PPAR-α target genes but does not alter expression of SREBP target genes in liver and adipose tissue of pigs.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXovVyhtbs%3D&md5=4860bcf8df41b01c35df2eb05ba52ebeCAS |
Marcil V, Delvin E, Sané AT, Tremblay A, Levy E (2006) Oxidative stress influences cholesterol efflux in THP-1 macrophages: role of ATP-binding cassette A1 and nuclear factors. Cardiovascular Research 72, 473–482.
| Oxidative stress influences cholesterol efflux in THP-1 macrophages: role of ATP-binding cassette A1 and nuclear factors.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XhtFKmtbrP&md5=f0557e9ebbaa2dbfd026a5db732a3a9cCAS |
Matthews JO, Southern LL, Higbie AD, Persica MA, Bidner TD (2001) Effects of betaine on growth, carcass characteristics, pork quality, and plasma metabolites of finishing pigs. Journal of Animal Science 79, 722–728.
Miida T, Seino U, Miyazaki O, Hanyu O, Hirayama S, Saito T, Ishikawa Y, Akamatsu S, Nakano T, Nakajima K, Okazaki M, Okada M (2008) Probucol markedly reduces HDL phospholipids and elevated prebeta1-HDL without delayed conversion into alpha-migrating HDL: putative role of angiopoietin-like protein 3 in probucol-induced HDL remodeling. Atherosclerosis 200, 329–335.
| Probucol markedly reduces HDL phospholipids and elevated prebeta1-HDL without delayed conversion into alpha-migrating HDL: putative role of angiopoietin-like protein 3 in probucol-induced HDL remodeling.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhtFyltrfE&md5=35f2f8639de78e5fbe905132e52120cdCAS |
Moon HS, Chung C, Lee HG, Kim TG, Choi YJ, Cho CS (2007) Inhibitory effect of (–)-epigallocatechin-3-gallate on lipid accumulation of 3T3–L1 cells. Obesity (Silver Spring, Md.) 15, 2571–2582.
| Inhibitory effect of (–)-epigallocatechin-3-gallate on lipid accumulation of 3T3–L1 cells.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXkvVGqtw%3D%3D&md5=8b5e958394ecb7af48be440906710b57CAS |
Mourot J, Hermier D (2001) Lipids in monogastric animal meat. Reproduction, Nutrition, Development 41, 109–118.
| Lipids in monogastric animal meat.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXltFWhs7s%3D&md5=9080ade6229559152a5223b245196cb7CAS |
NPPC (1991) ‘Procedures to evaluate market hogs.’ 3rd edn. (National Pork Producers Council; Des Moines, IA)
Oshida T, Sakata R, Yamada S, Horiguchi K, Itoh S, Matsumura H (2002) Effects of apple polyphenol on pig production and meat quality. Bulletin of Hygiene 7, 77–83.
Oyedeji JO, Atteh JO (2005) Response of broilers to feeding manipulations. International Journal of Poultry Science 4, 91–95.
| Response of broilers to feeding manipulations.Crossref | GoogleScholarGoogle Scholar |
Pal S, Ho N, Santos C, Dubois P, Mamo J, Croft K, Allister E (2003) Red wine polyphenolics increase LDL receptor expression and activity and suppress the secretion of ApoB100 from human HepG2 cells. The Journal of Nutrition 133, 700–706.
Payne RL, Bidner TD, Southern LL, Geaghan JP (2001) Effects of dietary soy isoflavones on growth, carcass traits, and meat quality in growing-finishing pigs. Journal of Animal Science 79, 1230–1239.
Rehfeldt C, Adamovic I, Kuhn G (2007) Effects of dietary daidzein supplementation of pregnant sows on carcass and meat quality and skeletal muscle cellularity of the progeny. Meat Science 75, 103–111.
| Effects of dietary daidzein supplementation of pregnant sows on carcass and meat quality and skeletal muscle cellularity of the progeny.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XhtVyit7fL&md5=20b641a46fbf43554721ca8e9df5a34eCAS |
Robciuc MR, Tahvanainen E, Jauhiainen M, Ehnholm C (2010) Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample. Journal of Lipid Research 51, 824–831.
| Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXjslenu74%3D&md5=7a128b1c1e4627ef779ecaf5faa970a1CAS |
Rush JW, Laughlin MH, Woodman CR, Price EM (2000) SOD-1 expression in pig coronary arterioles is increased by exercise training. American Journal of Physiology. Heart and Circulatory Physiology 279, H2068–H2076.
Wang CZ, Maier UH, Keil M, Zenk MH, Bacher A, Rohdich F, Eisenreich W (2003) Phenylalanine-independent biosynthesis of 1,3,5,8-tetrahydroxyxanthone. A retrobiosynthetic NMR study with root cultures of Swertia chirata. European Journal of Biochemistry 270, 2950–2958.
| Phenylalanine-independent biosynthesis of 1,3,5,8-tetrahydroxyxanthone. A retrobiosynthetic NMR study with root cultures of Swertia chirata.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXlvVChurw%3D&md5=071f33446959ba19a480c3f19514e416CAS |
Xiao HB, Sun ZL, Lu XY, Li DZ, Xu JP, Hu YP (2008) Beneficial effect of 3,4,5,6-tetrahydroxyxanthone on dyslipidemia in apolipoprotein E deficient mice. Canadian Journal of Physiology and Pharmacology 86, 815–826.
| Beneficial effect of 3,4,5,6-tetrahydroxyxanthone on dyslipidemia in apolipoprotein E deficient mice.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhsFSmtbnK&md5=7874b23bb9b42ba9fd58624b08762a9cCAS |
Yin W, Liao D, Kusunoki M, Xi S, Tsutsumi K, Wang Z, Lian X, Koike T, Fan J, Yang Y, Tang C (2004) NO-1886 decreases ectopic lipid deposition and protects pancreatic beta cells in diet-induced diabetic swine. The Journal of Endocrinology 180, 399–408.
| NO-1886 decreases ectopic lipid deposition and protects pancreatic beta cells in diet-induced diabetic swine.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXivVyksb0%3D&md5=929c83549b3fc56faf2f11beeda850e6CAS |
Zhang W, Xiao S, Lee EJ, Ahn DU (2011) Consumption of oxidized oil increases oxidative stress in broilers and affects the quality of breast meat. Journal of Agricultural and Food Chemistry 59, 969–974.
| Consumption of oxidized oil increases oxidative stress in broilers and affects the quality of breast meat.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXmsVSq&md5=bb8b987c8618f08c9ba79cf783941d67CAS |
Zhao S, Wang J, Song X, Zhang X, Ge C, Gao S (2010) Impact of dietary protein on lipid metabolism-related gene expression in porcine adipose tissue. Nutrition & Metabolism 7, 6
| Impact of dietary protein on lipid metabolism-related gene expression in porcine adipose tissue.Crossref | GoogleScholarGoogle Scholar |
Zhu XY, Bentley MD, Chade AR, Ritman EL, Lerman A, Lerman LO (2007) Early changes in coronary artery wall structure detected by microcomputed tomography in experimental hypercholesterolemia. American Journal of Physiology. Heart and Circulatory Physiology 293, H1997–H2003.
| Early changes in coronary artery wall structure detected by microcomputed tomography in experimental hypercholesterolemia.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhtVOqtrbP&md5=fe22e471a2594efbcfd952d3a704586eCAS |
