Latest

These articles are the latest published in the journal. Reproduction, Fertility and Development has moved to a continuous publication model. More information is available on our Continuous Publication page.

Published online 11 July 2024

RD23190Characterisation of germline progenitor cells in the testes of phylostomid bats: Artibeus jamaicensis and Sturnira lilium

Norma Moreno-Mendoza , Iván Cabrera-Campos, Noe Zacaula-Juárez and Tania J. Porras-Gómez

 

A population of sperm progenitor cells, known as Asingle spermatogonia, has been described in mammalian testes, but these cells have not been studied in bat testes. Bats are a good model due to their human-like reproductive characteristics. The results show the existence of spermatogonial stem cells that constantly renew spermatogenesis in these chiropterans, similar to that described in other mammals such as humans. Image by Tania Porras-Gómez and Norma Moreno-Mendoza.

RD23190 Abstract  | PDF (10.3 MB) - $35.00 

Published online 08 July 2024

RD23230The role of placental kisspeptin in trophoblast invasion and migration: an assessment in Kiss1r knockout mice, BeWo cell lines and human term placenta

E. N. Panting, J. H. Weight, J. A. Sartori , D. A. Coall and J. T. Smith

 

There is mounting evidence implicating kisspeptin signalling in placental development and function. We sought to elucidate kisspeptin’s role in the placenta using three experimental models: a mouse kisspeptin receptor knockout model, culture of human BeWo trophoblast cells, and a human placenta punch biopsy. Our results indicate that kisspeptin may inhibit trophoblast invasion, although further investigation is required to clarify specific regulatory mechanisms. Image by https://www.clker.com/clipart-white-mouse-1.html and adapted from M. Arvola and R. Mattsson (https://doi.org/10.1038/npg.els.0001438).

RD23230 Abstract  |  RD23230 Full Text  | RD23230PDF (1.2 MB)  | RD23230Supplementary Material (1.1 MB)   Open Access Article

Published online 08 July 2024

RD14398_COCorrigendum to: Interaction of the transforming growth factor-β and Notch signaling pathways in the regulation of granulosa cell proliferation

Xiao-Feng Sun, Xing-Hong Sun, Shun-Feng Cheng, Jun-Jie Wang, Yan-Ni Feng, Yong Zhao, Shen Yin, Zhu-Mei Hou, Wei Shen and Xi-Feng Zhang

 

RD14398_CO Full Text  | RD14398_COPDF (1 MB)

Published online 05 July 2024

RD24008The short-term effect of COVID-19 infection history on semen parameters in men referred to infertility centres

Negar Osatd-Rahim, Fatemeh Ghorbani, Mahsa Jalali, Fatemeh Karimi, Alireza Ebrahimzade-bideskan and Sareh Karimi

 

In recent years, the COVID-19 pandemic has been considered a threat to human health. The SARS-CoV-2 virus has caused various disorders in the body’s systems and the reproductive system is no exception. Based on the result of present study, COVID-19 infection increases the oxidative stress and reduces the semen quality, thus reducing the fertility potential. Illustration by Sareh Karimi.

RD24008 Abstract  | PDF (805 KB) - $35.00 

Published online 27 June 2024

RD23216The limitations of testicular organoids: are they truly as promising as we believe?

R. Mecca , S. Tang, C. Jones and K. Coward

 

Testicular organoids (TOs) represent a groundbreaking avenue captivating researchers seeking to understand and restore fertility. While TOs hold remarkable potential, their journey to replicate human spermatogenesis within a laboratory environment remains elusive. This review navigates the landscape of TOs, unveiling their unparalleled potential while dissecting the challenges hindering their success, helping refine these models for transformative clinical applications. Photograph by K. Coward..

This article belongs to the Collection Dedication to Jim Cummins.

RD23216 Abstract  | PDF (2.4 MB) - $35.00 

Published online 21 June 2024

RD23233Differential effect of melatonin on ram spermatozoa depending on the allelic variant of the RsaI polymorphism of the MTR1A gene, incubation medium and season

Victoria Peña-Delgado , Agustí Noya , Melissa Carvajal-Serna , José A Abecia , Rosaura Pérez-Pe and Adriana Casao

 

Melatonin regulates seasonal reproduction in ovine species. This study explores the influence of the melatonin receptor gene and its variants on the response of ram spermatozoa to melatonin in different seasons and media. Results revealed that having specific variants of the gene affects how sperm cells react to melatonin. Understanding these genetic variations could aid in enhancing reproductive techniques in ovine species. Image by Victoria Peña-Delgado.

This article belongs to the Collection Non-photoperiodic Actions of Melatonin.

RD23233 Abstract  |  RD23233 Full Text  | RD23233PDF (1.6 MB)  | RD23233Supplementary Material (1.3 MB)   Open Access Article

Published online 20 June 2024

RD24047A brief history of technical developments in intracytoplasmic sperm injection (ICSI). Dedicated to the memory of J.M. Cummins

J. G. Thompson , H. J. McLennan , S. L. Heinrich , M. P. Inge , D. K. Gardner and A. J. Harvey

 

Intracytoplasmic sperm injection, better known by its acronym ‘ICSI’, is a technique that enables the injection of a single sperm into an egg. Since first practiced in 1992 with human sperm and eggs, it has revolutionised the treatment of male infertility, and an estimated 6 million children have since been born. However, it is not without controversy, especially concerning the long-term health of children conceived through ICSI, as well as the recent push towards automation of sperm selection and injection. Image by M. Inge.

This article belongs to the Collection Dedication to Jim Cummins.

RD24047 Abstract  |  RD24047 Full Text  | RD24047PDF (398 KB)   Open Access Article

Published online 20 June 2024

RD24018Efficiency of embryo complementation and pluripotency maintenance following multiple passaging of in vitro-derived bovine embryos

Maura S. McGraw, Jordan A. Bishman and Bradford W. Daigneault

 

Reproductive technologies that advance in vitro embryo production while directing cell lineage specification are beneficial for both agriculture and biomedical applications. Multiple passaging of bovine embryos subjected to blastomere complementation allows for the production of genetically identical embryos from a single fertilised egg while shifting cell lineage pluripotency towards trophectoderm lineage specification. These findings may be further developed as alternative strategies for producing genetically identical cattle with desirable traits and trophoblast stem cell models for embryo technologies and placental biology. Diagram by Bradford W. Daigneault and Maura S. McGraw.

RD24018 Abstract  | PDF (2.2 MB) - $35.00   | RD24018Supplementary Material (736 KB)

Published online 17 June 2024

RD23174Expression of transforming growth factor β signalling molecules and their correlations with genes in loci linked to polycystic ovary syndrome in human foetal and adult tissues

Rafiatu Azumah, Katja Hummitzsch, Richard A. Anderson and Raymond J. Rodgers

 

Polycystic ovary syndrome (PCOS) is a complex disorder with an unknown aetiology; although foetal and genetic origins have been implicated. Ovaries of PCOS women are more fibrous, suggesting involvement of transforming growth factor beta (TGFβ) signalling molecules. We identified strong correlations between TGFβ signalling molecules and PCOS candidate genes in multiple human foetal tissues associated with reproduction, metabolism, and neurology. Thus, alteration in TGFβ signalling during foetal development could affectdevelopment of multiple organs leading to the numerous symptoms of PCOS observed in adult life. Image by Katja Hummitzsch.

RD23174 Abstract  |  RD23174 Full Text  | RD23174PDF (1.4 MB)  | RD23174Supplementary Material (2.1 MB)   Open Access Article

Published online 13 June 2024

RD23133Protective effect of curcumin on testicular damage caused by carbon tetrachloride exposure in rats

Aysel Bayramova , Mete Keçeci , Meryem Akpolat and Osman Cengil

 

Carbon tetrachloride (CCl₄) is a chemical widely used in industry. Although CCl₄ exposure has significant toxicity on the liver, there are also experimental studies showing that it causes testicular damage through oxidative stress. Curcumin is a powerful antioxidant nutraceutical. Our study showed that curcumin can prevent CCl₄-mediated testicular injury with its antioxidant, anti-inflammatory and antiapoptotic properties. Illustration by Mete Keçeci.

RD23133 Abstract  | PDF (17.8 MB) - $35.00 

Published online 13 June 2024

RD23227Influence of extracellular ATP on mammalian sperm physiology

I. López-González , I. Oseguera-López , R. Castillo and A. Darszon

 

Reproductive systems express different ion channels and transporters that release ATP into their lumens, which may regulate sperm physiology. Epididymal ATP has been suggested to influence basal sperm motility. Oviductal ATP triggers a head sperm volume increase which contributes to acrosome reaction. Image by López-González, I.

This article belongs to the Collection Dedication to Jim Cummins.

RD23227 Abstract  | PDF (893 KB) - $35.00 

Published online 03 June 2024

RD24065From cardiovascular protection to cardiovascular risk: the metamorphosis of menopausal hormone therapy

Bronwyn G. A. Stuckey

 

The metamorphosis from perceived cardiovascular protection to perceived cardiovascular risk, a perception largely led by the Women’s Health Initiative study, has shifted the clinician’s risk/benefit decision-making away from prescribing menopausal hormone therapy (MHT) for menopausal symptoms. A more nuanced view of the literature and the greater availability of different modes of delivery and formulations of MHT should give the clinician the knowledge and confidence to prescribe appropriate MHT for the greater benefit of midlife health and cardiovascular safety. Image by Bronwyn G. A. Stuckey.

RD24065 Abstract  |  RD24065 Full Text  | RD24065PDF (263 KB)   Open Access Article

Published online 28 May 2024

RD24001Protocol for the controlled reproduction of the edible frog Aubria subsigillata in aquaculture hatcheries in the Republic of Benin

Houénafa A. C. Gansa , Geraud D. Akélé and Hyppolite Agadjihouèdé

 

The frog Aubria subsigillata is an edible species that is highly valued in the human diet in Benin. However, a strong rarefaction of the species due to its uncontrolled exploitation is observed in the wild. The 0.2 IU/g of Ovulin hormone administered intrafemorally enabled collection of gametes at 13 h in males and 27 h in females, and 172 eggs of 1 mg were incubated after 167 h. A. subsigillata reproduction goes through five phases: (1) selection of mature broodstock; (2) hormonal injection; (3) gamete collection; (4) in vitro fertilisation; and (5) incubation. Photograph by Houénafa A. C. Gansa.

RD24001 Abstract  | PDF (659 KB) - $35.00 

Published online 20 May 2024

RD23132Clustering of spermatozoa examined through flow cytometry provides more information than the conventional assessment: a resilience to osmotic stress example

Julian Valencia , Sebastián Bonilla-Correal, Elisabeth Pinart, Sergi Bonet and Marc Yeste

 

Evaluation of sperm quality in farm animals and humans is crucial to predict reproductive efficiency, yet conventional tests are not sufficient to predict fertility. Clustering sperm using individual data from flow cytometry analysis provides more information than typical dot plots, which could better predict sperm fertility and cryotolerance. Herein, combining cluster analysis with flow cytometry led to the identification of five sperm subpopulations with differences in cell volume and membrane integrity, whereas typical dot plots just allowed for the identification of three. Image by the authors.

This article belongs to the Collection Dedication to Jim Cummins.

RD23132 Abstract  | PDF (4.9 MB) - $35.00   | RD23132Supplementary Material (930 KB)

Published online 16 May 2024

RD23235Genotyping of rams based on melatonin receptor 1A gene polymorphisms: a tool in sire selection?

Victoria Peña-Delgado , Agustí Noya , Melissa Carvajal-Serna , Francisco Canto , María Carmen Sánchez, Eva Letosa, Antonio Vicente, Ignacio Morato, Ángel Macías, José Alfonso Abecia , Adriana Casao and Rosaura Pérez-Pe

 

Some variants of the melatonin receptor gene affect seasonal reproduction in sheep, but it is not clear how they affect males and their spermatozoa. This study explores the impact of two genetic variants of the melatonin receptor gene on ram seminal quality throughout the year. Results revealed that there is a detrimental effect on seminal quality, more pronounced during the reproductive season, depending on the variant carried, which highlights the potential of genotyping for optimal sire selection in breeding programs. Image by Victoria Peña-Delgado.

This article belongs to the Collection Dedication to Jim Cummins.

RD23235 Abstract  |  RD23235 Full Text  | RD23235PDF (1.8 MB)  | RD23235Supplementary Material (729 KB)   Open Access Article

More content

Just Accepted

These articles have been peer reviewed and accepted for publication. They are still in production and have not been edited, so may differ from the final published form.

RD23214, Accepted 15 July 2024

Pathogenetic role of a number of factors in the development and progression of preeclampsia with varying severity in pregnant women

Irina Ismailova , Yulia Zame, Moldir Akhmedzhanova, Kuanysh Sultanov and Galiya Tanzharykova

 

RD23214Abstract

RD24079, Accepted 11 July 2024

ShinySperm: Navigating the Sperm Proteome Landscape

David Skerrett-Byrne , Raffaele Teperino and Brett Nixon

 

RD24079Abstract

RD24027, Accepted 04 July 2024

The role of asprosin in regulating ovarian granulosa and theca cell steroidogenesis: A review with comparisons to other adipokines

Excel Maylem, Luis Schutz and Leon Spicer

 

RD24027Abstract

RD24060, Accepted 27 June 2024

Leptin in reproduction and hypertension in pregnancy

Harbindar Singh, Fayez Almabhouh , Hisham Al-shaikhli , Maryam Hassan, Suzanna Daud, Rosfayati Othman and Muhd Fakh Md Salleh

 

RD24060Abstract

RD23217, Accepted 27 June 2024

Asian elephant (Elephas maximus) seminal plasma: Establishing the proteome and effect on spermatozoa when added to cryomedium

Cameron Negus, Anuchai Pinyopummin, Sittidet Mahasawangkul, Rebecca Hobbs and Roslyn Bathgate

 

RD23217Abstract

RD20302, Accepted 03 February 2021

RAF1 mediates the FSH signaling pathway as a downstream molecule to stimulate estradiol synthesis and secretion in mouse ovarian granulosa cells

Xuan Luo, Hui Liu, Hongzhou Guo, Longjie Sun, Kemian Gou and Sheng Cui

 

RD20302Abstract

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1. The perils of poly- and perfluorinated chemicals on the reproductive health of humans, livestock, and wildlife

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10. Differential effect of melatonin on ram spermatozoa depending on the allelic variant of the RsaI polymorphism of the MTR1A gene, incubation medium and season

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