Daily prolactin pulse inhibits the corpus luteum during lactational quiescence in the marsupial, Macropus eugenii
L. A. Hinds A B D and C. H. Tyndale-Biscoe A C
+ Author Affiliations
- Author Affiliations
A CSIRO Wildlife and Ecology, Lyneham, ACT 2602, Australia.
B CSIRO Ecosystem Sciences, GPO Box 1700, Canberra, ACT 2601, Australia.
C Present address: 114 Grayson Street, Hackett, ACT 2602, Australia.
D Corresponding author. Email: lyn.hinds@csiro.au
Reproduction, Fertility and Development 25(2) 456-461 https://doi.org/10.1071/RD11228
Submitted: 7 September 2011 Accepted: 9 April 2012 Published: 24 May 2012
Abstract
The corpus luteum (CL) of the tammar wallaby is inhibited by prolactin during lactation and seasonal quiescence. In seasonal quiescence a daily transient pulse of prolactin (PRL) of less than 2 h duration is sufficient to maintain inhibition. We investigated whether the same inhibition applies in lactation and, if so, how. Our results show that inhibition of the CL during lactation is maintained by a transient pulse of prolactin once a day. They also show that the minimum time without a PRL pulse for the CL to escape inhibition is more than 48 h and less than 72 h. Nevertheless, some animals had a longer refractory period than 72 h, which was reflected in a longer interval to the progesterone peak and birth. These results support the previous conclusion that PRL exercises its effect on a rate-limiting step in progesterone synthesis and secretion rate from the CL, which precedes any increase in its mass. Therefore, we conclude that the role of PRL is to act as a luteostatic agent, an effect that is in marked contrast to its luteotrophic effect in many eutherian species, including rodents.
Additional keywords: luteal cells, luteostatic, progesterone, refractory, tammar wallaby.
References
Berger, P. J. (1970). The reproductive biology of the tammar wallaby, Macropus eugenii Desmarest (Marsupialia). PhD thesis, Tulane University.Bradshaw, F. J., and Bradshaw, D. (2011). Progesterone and reproduction in marsupials: a review. Gen. Comp. Endocrinol. 170, 18–40.
| Progesterone and reproduction in marsupials: a review.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhs1Wqu7bP&md5=5efdcebe81489790caea36b9dcaf1131CAS | 20688062PubMed |
Crawford, J. L., Mester, B., Thomson, B., Lawrence, S. B., and Eckery, D. C. (2011). Prolactin acts on the hypothalamic–pituitary axis to modulate follicle-stimulating hormone gene expression in the female brushtail possum (Trichosurus vulpecula). Gen. Comp. Endocrinol. 171, 39–45.
| Prolactin acts on the hypothalamic–pituitary axis to modulate follicle-stimulating hormone gene expression in the female brushtail possum (Trichosurus vulpecula).Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhvFKis7g%3D&md5=ffba19d4d3450408b10ab137c7ceb110CAS | 21187096PubMed |
Dobson, A. J., and Barnett, A. G. (2008). ‘An Introduction to Generalized Linear Models’. 3rd edn. (CRC Press: Boca Raton, FL.)
Gordon, K., Fletcher, T. P., and Renfree, M. B. (1988). Reactivation of the quiescent corpus luteum and diapausing embryo after temporary removal of the sucking stimulus in the tammar wallaby (Macropus eugenii). J. Reprod. Fertil. 83, 401–406.
| Reactivation of the quiescent corpus luteum and diapausing embryo after temporary removal of the sucking stimulus in the tammar wallaby (Macropus eugenii).Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaL1c3os1Ggug%3D%3D&md5=af5a1926349d7fe9aad88cbdade2ab25CAS | 3397949PubMed |
Hinds, L. A. (1983). Progesterone and prolactin in marsupial reproduction. PhD Thesis, Australian National University, Canberra.
Hinds, L. A. (1989). Morning prolactin pulse maintains seasonal quiescence in the tammar wallaby, Macropus eugenii. J. Reprod. Fertil. 87, 735–744.
| Morning prolactin pulse maintains seasonal quiescence in the tammar wallaby, Macropus eugenii.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK3cXhs1GhtQ%3D%3D&md5=e4ba5053e0a704f4e5ea8ae218e05bdaCAS | 2600921PubMed |
Hinds, L. A. (1994). Prolactin, a hormone for all seasons: endocrine regulation of seasonal breeding in the Macropodidae. Oxf. Rev. Reprod. Biol. 16, 247–299.
Hinds, L. A., and Tyndale-Biscoe, C. H. (1985). Seasonal and circadian patterns of circulating prolactin during lactation and seasonal quiescence in the tammar, Macropus eugenii. J. Reprod. Fertil. 74, 173–183.
| Seasonal and circadian patterns of circulating prolactin during lactation and seasonal quiescence in the tammar, Macropus eugenii.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL2MXks1GgtL0%3D&md5=6f655cbfdcc4a5f0a1b742ce8b5c8d0fCAS | 4020766PubMed |
Hughes, R. L., Hall, L. S., Tyndale-Biscoe, C. H., and Hinds, L. A. (1989). Evolutionary implications of macropodoid organogenesis. In ‘Kangaroos, Wallabies and Rat Kangaroos’. pp. 377–405. (Australian Mammal Society and Surrey Beatty: Sydney.)
Kojima, T., Hinds, L. A., Muller, W. J., O’Neill, C., and Tyndale-Biscoe, C. H. (1993). In vitro production and secretion of progesterone and presence of platelet activating factor (PAF) in early pregnancy of the marsupial, Macropus eugenii. Reprod. Fertil. Dev. 5, 15–25.
| In vitro production and secretion of progesterone and presence of platelet activating factor (PAF) in early pregnancy of the marsupial, Macropus eugenii.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2cXht1Ghurc%3D&md5=f07129ae11a461177dceded3d0c29cf0CAS | 8234890PubMed |
Kowalewski, M. P., Michel, E., Gram, A., Boos, A., Guscetti, F., Hoffmann, B., Aslan, S., and Reichler, I. (2011). Luteal and placental function in the bitch: spatio-temporal changes in prolactin receptor (PRLr) expression at dioestrus, pregnancy and normal and induced parturition. Reprod. Biol. Endocrinol. 9, 109–120.
| Luteal and placental function in the bitch: spatio-temporal changes in prolactin receptor (PRLr) expression at dioestrus, pregnancy and normal and induced parturition.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtFGktrzE&md5=174d64e5a5e0e721b5bb5b8a7ad0ea8eCAS | 21812980PubMed |
McConnell, S. J., Tyndale-Biscoe, C. H., and Hinds, L. A. (1986). Change in duration of elevated melatonin is the major factor in photoperiod response of the tammar, Macropus eugenii. J. Reprod. Fertil. 77, 623–632.
| Change in duration of elevated melatonin is the major factor in photoperiod response of the tammar, Macropus eugenii.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL28XltV2isL8%3D&md5=b1fee942a95efe689cb337763e943c65CAS | 3735254PubMed |
Mead, R. A. (1993). Embryonic diapause in vertebrates. J. Exp. Zool. 266, 629–641.
| Embryonic diapause in vertebrates.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK3szotFCmsg%3D%3D&md5=08ae2fbf21e33ad4ae5f46fddb4cd070CAS | 8371102PubMed |
Niswender, G. D. (2002). Molecular control of luteal secretion of progesterone. Reproduction 123, 333–339.
| Molecular control of luteal secretion of progesterone.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38Xit1Clsr8%3D&md5=0bdb043c857dc7f746163c279eb2cee6CAS | 11882010PubMed |
Poole, W. E. (1975). Reproduction in the two species of grey kangaroos, Macropus giganteus Shaw and M. fuliginosus (Desmarest). II Gestation, parturition and pouch life. Aust. J. Zool. 23, 333–353.
| Reproduction in the two species of grey kangaroos, Macropus giganteus Shaw and M. fuliginosus (Desmarest). II Gestation, parturition and pouch life.Crossref | GoogleScholarGoogle Scholar |
Rothchild, I. (1981). The regulation of the mammalian corpus luteum. Recent Prog. Horm. Res. 37, 183–298.
| 1:CAS:528:DyaL3MXlvVCntrw%3D&md5=34deaede4e6592063424ec6abcbf3a8aCAS | 7025133PubMed |
Sernia, C., Hinds, L. A., and Tyndale-Biscoe, C. H. (1980). Progesterone metabolism during embryonic diapause in the tammar wallaby, Macropus eugenii. J. Reprod. Fertil. 60, 139–147.
| Progesterone metabolism during embryonic diapause in the tammar wallaby, Macropus eugenii.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL3cXlvVeltbc%3D&md5=deb793b483944db686811cc77dc9e195CAS | 7431315PubMed |
Stewart, F., and Tyndale-Biscoe, C. H. (1982). Prolactin and luteinizing hormone receptors in marsupial corpora lutea: relationship to control of luteal function. J. Endocrinol. 92, 63–72.
| Prolactin and luteinizing hormone receptors in marsupial corpora lutea: relationship to control of luteal function.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL38Xhs1Sisbk%3D&md5=74a9b534ad2cd44a1cf0f209421845c3CAS | 6276490PubMed |
Stocco, C., Telleria, C., and Gibori, G. (2007). The molecular control of corpus luteum formation function and regression. Endocr. Rev. 28, 117–149.
| The molecular control of corpus luteum formation function and regression.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXjtFCgsrc%3D&md5=8e1a123bdd1c6e80e7ec5a5b70f7fcd9CAS | 17077191PubMed |
Tyndale-Biscoe, C. H., and Hinds, L. A. (1984). Seasonal patterns of circulating progesterone and prolactin and response to bromocriptine in the female tammar, Macropus eugenii. Gen. Comp. Endocrinol. 53, 58–68.
| Seasonal patterns of circulating progesterone and prolactin and response to bromocriptine in the female tammar, Macropus eugenii.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL2cXivF2msA%3D%3D&md5=1e2243c1a35ce8fe62dad6dfd58e075bCAS | 6714652PubMed |
Tyndale-Biscoe, C. H., Hinds, L. A., and McConnell, S. J. (1986). Seasonal breeding in a marsupial: opportunities of a new species for an old problem. Recent Prog. Horm. Res. 42, 471–512.
| 1:CAS:528:DyaL28XmtFyqsbg%3D&md5=9cf927dca75323e8a86a1c96fe20fe79CAS | 3526455PubMed |
Tyndale-Biscoe, C. H., Hinds, L. A., and Horn, C. A. (1988). Fetal role in the control of parturition in the tammar, Macropus eugenii. J. Reprod. Fertil. 82, 419–428.
| Fetal role in the control of parturition in the tammar, Macropus eugenii.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL1cXhs1Wrsro%3D&md5=cbbe0e0c9a9855be3a67a3be8855d579CAS | 3361479PubMed |
