
TY  - JOUR
A1  - Riggs, AD 
T1  - Marsupials and Mechanisms of X-Chromosome Inactivation
JF  - Australian Journal of Zoology
JO  - Aust. J. Zool.
Y1  - 1989
VL  - 37
IS  - 3
SP  - 419
EP  - 441
KW  - 
UR  - https://doi.org/10.1071/ZO9890419 
N2  - X chromosome inactivation is reviewed with molecular mechanisms in mind. Models for the various steps leading to the establishment and maintenance of X inactivation are discussed, with comparisons between eutherians and marsupials included. Late DNA replication is proposed to be an epigenetic, self-propagating mechanism aiding the somatic inheritance of determined states, and thus could be the ancestral mechanism for X inactivation. Also, a novel mechanism, Type I DNA-reeling, is proposed to maintain higher order chromosome structure and to help explain the cis-spreading of X inactivation. 
ER  -

