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RESEARCH ARTICLE
Contents Vol 34(7)

Prospects for fertility control in the European rabbit (Oryctolagus cuniculus) using myxoma virus-vectored immunocontraception

B. H. van Leeuwen A and P. J. Kerr A B
+ Author Affiliations
- Author Affiliations

A School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT, Australia.

B Corresponding author. CSIRO Entomology, GPO Box 1700, Canberra, ACT 2601, Australia. Email: peter.kerr@csiro.au

Wildlife Research 34(7) 511-522 https://doi.org/10.1071/WR06167
Submitted: 1 December 2006  Accepted: 26 July 2007   Published: 13 December 2007

Abstract

Research over the last 15 years has examined whether fertility control can reduce overabundant rabbit populations and whether an effective immunocontraceptive agent can be developed and delivered. The results of this research indicate that for fertility control to have an environmental impact at least 80% of females will need to be infertile and that this infertility will need to be permanent. Epidemiological studies suggest that this level of infertility may be very difficult to obtain with a recombinant myxoma virus because of competition with field strains of virus. Research with laboratory rabbits using recombinant myxoma virus to deliver an immunocontraceptive antigen demonstrated that it was possible to obtain the required level of infertility using rabbit zona pellucida C as an antigen. However, only ~50% of animals remained infertile in the medium term. Further research on delivery vector and antigen selection would be needed to produce a practical immunocontraceptive virus for laboratory testing. Such a virus would then need to be optimised for transmissibility before it would be suitable for field testing.


Acknowledgements

We thank our colleagues A. J. Robinson, E. A. McLaughlin, M. K. Holland, H. D. Perkins, A. Wijeratne, B. Inglis, L. E. Perrin and N. French, who contributed to the experimental studies and the unpublished data described in this review.


References

Anderson, R. M. , and May, R. M. (1982). Coevolution of hosts and parasites. Parasitology 85, 411–426.
| PubMed | Burnet M. (1968). ‘Changing Patterns.’ (Heinemann: Melbourne.)

Cameron, C. , Hota-Mitchell, S. , Chen, L. , Barrett, J. , Cao, J.-X. , Macaulay, C. , Willer, D. , Evans, D. , and McFadden, G. (1999). The complete DNA sequence of myxoma virus. Virology 264, 298–318.
| Crossref | GoogleScholarGoogle Scholar | PubMed | Fenner F., and Fantini B. (1999). ‘Biological Control of Vertebrate Pests. The History of Myxomatosis – an Experiment in Evolution.’ (CAB International: New York.)

Fenner, F. , and Marshall, I. D. (1957). A comparison of the virulence for European rabbits (Oryctolagus cuniculus) of strains of myxoma virus recovered in the field in Australia, Europe and America. Journal of Hygiene (Cambridge) 55, 149–151.
Fenner F., and Ratcliffe F. N. (1965). ‘Myxomatosis.’ (Cambridge University Press: Cambridge.)

Flux J. E. C. (1994). World distribution. In ‘The European Rabbit. The History and Biology of a Successful Colonizer’. (Eds H. V. Thompson and C. M. King.) pp. 8–21. (Oxford University Press: Oxford.)

Fountain, S. , Holland, M. K. , Hinds, L. A. , Janssens, P. A. , and Kerr, P. J. (1997). Interstitial orchitis with impaired steroidogenesis and spermatogenesis in the testes of rabbits infected with an attenuated strain of myxoma virus. Journal of Reproduction and Fertility 110, 161–169.
| PubMed | Kerr P., van Leeuwen B., Perkins H., Holland M., Gu W., Jackson R., Williams C., and Robinson A. (2001). Development of fertility control for wild rabbits in Australia using a virally-vectored immunocontraceptive. In ‘Enhancing Biocontrol Agents and Handling Risks’. (Eds M. Vurro and J. Gressel.) pp. 14–27. (IOS Press: Amsterdam.)

Kerr, P. J. , and McFadden, G. (2002). Immune responses to myxoma virus. Viral Immunology 15, 229–246.
| Crossref | GoogleScholarGoogle Scholar | PubMed | Martin C. J. (1936). Observations on Myxomatosis cuniculi (Sanarelli) made with a view to the use of the virus in the control of rabbit plagues. Council for Scientific and Industrial Research Australia Research Bulletin No. 96.

McCabe, V. J. , Tarpey, I. , and Spibey, N. (2002). Vaccination of cats with an attenuated recombinant myxoma virus expressing feline calicivirus capsid protein. Vaccine 20, 2454–2462.
| Crossref | GoogleScholarGoogle Scholar | PubMed | Myers K., Parer I., Wood D., and Cooke B. D. (1994). The rabbit in Australia. In ‘The European Rabbit. The History and Biology of a Successful Colonizer’. (Eds H. V. Thompson and C. M. King.) pp. 108–157. (Oxford University Press: Oxford.)

Mykytowycz, R. (1953). An attenuated strain of the myxomatosis virus recovered from the field. Nature 172, 448–449.
| Crossref | GoogleScholarGoogle Scholar | PubMed | Rolls E. C. (1969). ‘They All Ran Wild.’ (Angus and Robertson: Melbourne.)

Russell, R. J. , and Robbins, S. J. (1989). Cloning and molecular characterization of the myxoma virus genome. Virology 170, 147–159.
| Crossref | GoogleScholarGoogle Scholar | PubMed | Williams K., Parer I., Coman B., Burley J., and Braysher M. (1995). ‘Managing Vertebrate Pests: Rabbits.’ (Australian Government Publishing Services: Canberra.)