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Wildlife Research Wildlife Research Society
Ecology, management and conservation in natural and modified habitats
COMMENT AND RESPONSE

Efficacy of SpayVac® is excellent: a comment on Gray et al. (2010)

Mark A. Fraker A C and Robert G. Brown B
+ Author Affiliations
- Author Affiliations

A TerraMar Environmental Research Ltd, Sidney, BC, Canada.

B ImmunoVaccine, Inc., Halifax, NS, Canada.

C Corresponding author. Email: maf@terramarresearch.com

Wildlife Research 38(6) 537-538 https://doi.org/10.1071/WR11079
Submitted: 26 April 2011  Accepted: 18 August 2011   Published: 11 November 2011

Abstract

In reporting the results of a trial of contraceptive vaccines in wild horses, Gray et al. (2010) misidentified one of the vaccines as SpayVac®, a porcine zona pellucida (pZP) vaccine that owes its typically very high efficacy to a special DepoVax® liposome technology. We believe that the absence of DepoVax® liposomes ought to have been considered as a possible explanation for the unexpectedly low efficacy that was observed.

Additional keywords: fertility control, immunocontraception, pZP vaccine, SpayVac®, wild horses.


References

Brown, R. G., Bowen, W. D., Eddington, J. D., Kimmins, W. C., Mezei, M., Parsons, J. L., and Pohajdak, B. (1997). Evidence for a long-lasting, single administration contraceptive in wild grey seals. Journal of Reproductive Immunology 35, 43–51.
Evidence for a long-lasting, single administration contraceptive in wild grey seals.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2sXms1eqs74%3D&md5=25c40af347d8a1722b1ef33f0c7cf86fCAS |

Fraker, M. A., Brown, R. G., Gaunt, G. E., Kerr, J. A., and Pohajdak, B. (2002). Long-lasting, single-dose immunocontraception of feral fallow deer in British Columbia. The Journal of Wildlife Management 66, 1141–1147.
Long-lasting, single-dose immunocontraception of feral fallow deer in British Columbia.Crossref | GoogleScholarGoogle Scholar |

Gray, M. E., Thain, D. S., Cameron, E. Z., and Miller, L. A. (2010). Multi-year fertility reduction in free-roaming feral horses with single-injection immunocontraceptive formulations. Wildlife Research 37, 475–481.
Multi-year fertility reduction in free-roaming feral horses with single-injection immunocontraceptive formulations.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhsVCht7%2FI&md5=712696b709a9285e14d05b9873430d64CAS |

Gray, M. E., Thain, D. S., Cameron, E. Z., and Miller, L. A. (2011). Erratum. Wildlife Research 38, 260.
Erratum.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXoslCmsbs%3D&md5=d9e41309b336df0e067502f055817cbbCAS |

Hernandez, S. (2005). Effects of SpayVac™ on urban white-tailed deer at the Johnson Space Center. M.Sc. Thesis. Texas A&M University, College Station, TX.

Hernandez, S., Locke, S. L., Cook, M. W., Harveson, L. A., Davis, D. S., Lopez, R. R., Silvy, N. J., and Fraker, M. A. (2006). Effects of SpayVac® on urban female white-tailed deer movements. Wildlife Society Bulletin 34, 1430–1434.
Effects of SpayVac® on urban female white-tailed deer movements.Crossref | GoogleScholarGoogle Scholar |

Killian, G., Thain, D., Diehl, N. K., Rhyan, J., and Miller, L. (2008). Four-year contraceptive rates of mares treated with single-injection porcine zona pellucida and GnRH vaccines and intrauterine devices. Wildlife Research 35, 531–539.
Four-year contraceptive rates of mares treated with single-injection porcine zona pellucida and GnRH vaccines and intrauterine devices.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXht1KrtLjJ&md5=c7ac6e2e7ec61b2f2a49a238551a6235CAS |

Miller, L. A., Fagerstone, K. A., Wagner, D. C., and Killian, G. J. (2009). Factors contributing to the success of a single-shot, multiyear PZP immunocontraceptive vaccine for white-tailed deer. Human–Wildlife Conflicts 3, 103–115.