Transforming growth factor-β superfamily and interferon-τ in ovarian function and embryo development in female cattle: review of biology and application
Michael J. D’Occhio A , Giuseppe Campanile B and Pietro S. Baruselli C DA School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, 410 Werombi Road, Camden, NSW 2006, Australia.
B Department of Veterinary Medicine and Animal Production, University of Naples Federico II, V. F. Delpino, 1 80137 Naples, Italy.
C Department of Animal Reproduction, Faculty of Veterinary Medicine and Zootecnia, University of Sao Paulo, Sao Paulo, CEP 05508-270 Brazil.
D Corresponding author. Email: barusell@usp.br
Reproduction, Fertility and Development 32(6) 539-552 https://doi.org/10.1071/RD19123
Submitted: 1 April 2019 Accepted: 16 September 2019 Published: 6 February 2020
Abstract
Survival of the embryo and establishment of a pregnancy is a critical period in the reproductive function of female cattle. This review examines how the transforming growth factor-β (TGFB) superfamily (i.e. bone morphogenetic protein (BMP) 15, growth differentiation factor (GDF) 9, anti-Müllerian hormone (AMH)) and interferon-τ (IFNT) affect ovarian function and embryo development. The oocyte in a primary follicle secretes BMP15 and GDF9, which, together, organise the surrounding granulosa and theca cells into the oocyte–cumulus–follicle complex. At the same time, the granulosa secretes AMH, which affects the oocyte. This autocrine–paracrine dialogue between the oocyte and somatic cells continues throughout follicle development and is fundamental in establishing the fertilisation potential and embryo developmental competency of oocytes. The early bovine embryo secretes IFNT, which acts at the uterine endometrium, corpus luteum and blood leucocytes. IFNT is involved in the maternal recognition of pregnancy and immunomodulation to prevent rejection of the embryo, and supports progesterone secretion. Manipulation of BMP15, GDF9, AMH and IFNT in both in vivo and in vitro studies has confirmed their importance in reproductive function in female cattle. This review makes the case that a deeper understanding of the biology of BMP15, GDF9, AMH and IFNT will lead to new strategies to increase embryo survival and improve fertility in cattle. The enhancement of oocyte quality, early embryo development and implantation is considered necessary for the next step change in the efficiency of natural and assisted reproduction in cattle.
Additional keywords: anti-Müllerian hormone, bone morphogenetic protein 15, embryo survival, growth differentiation factor 9.
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