Logistics of large scale commercial IVF embryo production
P. Blondin
+ Author Affiliations
- Author Affiliations
Boviteq and Semex Alliance, 19320 Grand Rang St-Francois, St-Hyacinthe, Quebec J2T 5H1, Canada. Email: pblondin@semex.com
Reproduction, Fertility and Development 29(1) 32-36 https://doi.org/10.1071/RD16317
Published: 2 January 2017
Abstract
The use of IVF in agriculture is growing worldwide. This can be explained by the development of better IVF media and techniques, development of sexed semen and the recent introduction of bovine genomics on farms. Being able to perform IVF on a large scale, with multiple on-farm experts to perform ovum pick-up and IVF laboratories capable of handling large volumes in a consistent and sustainable way, remains a huge challenge. To be successful, there has to be a partnership between veterinarians on farms, embryologists in the laboratory and animal owners. Farmers must understand the limits of what IVF can or cannot do under different conditions; veterinarians must manage expectations of farmers once strategies have been developed regarding potential donors; and embryologists must maintain fluent communication with both groups to make sure that objectives are met within predetermined budgets. The logistics of such operations can be very overwhelming, but the return can be considerable if done right. The present mini review describes how such operations can become a reality, with an emphasis on the different aspects that must be considered by all parties.
Additional keywords: agriculture, blastocyst, bovine, competence, oocyte, ovum pick-up.
References
Abdullah, R. B., Liow, S. L., Rahman, A. N., Chan, W. K., Wan-Khadijah, W. E., and Ng, S. C. (2008). Prolonging the interval from ovarian hyperstimulation to laparoscopic ovum pick-up improves oocyte yield, to embryo quality, and developmental competence in goats. Theriogenology 70, 765–771.| Prolonging the interval from ovarian hyperstimulation to laparoscopic ovum pick-up improves oocyte yield, to embryo quality, and developmental competence in goats.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhtVamt7%2FJ&md5=6e6b7891ca4cc733e083b7d4627129abCAS |
Abe, H., Yamashita, S., Satoh, T., and Hoshi, H. (2002). Accumulation of cytoplasmic lipid droplets in bovine embryos and cryotolerance of embryos developed in different culture systems using serum-free or serum-containing media. Mol. Reprod. Dev. 61, 57–66.
| Accumulation of cytoplasmic lipid droplets in bovine embryos and cryotolerance of embryos developed in different culture systems using serum-free or serum-containing media.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXptVejur4%3D&md5=7e6fee4e2032e151d586293c29e05dceCAS |
Durocher, J., Morin, N., and Blondin, P. (2006). Effect of hormonal stimulation on bovine follicular response and oocyte developmental competence in a commercial operation. Theriogenology 65, 102–115.
| Effect of hormonal stimulation on bovine follicular response and oocyte developmental competence in a commercial operation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXht1GitrzK&md5=0d4f1a2292753c1ea6bb1a85274bc542CAS |
Farin, P. W., Piedrahita, J. A., and Farin, C. E. (2006). Errors in development of fetuses and placentas from in vitro-produced bovine embryos. Theriogenology 65, 178–191.
| Errors in development of fetuses and placentas from in vitro-produced bovine embryos.Crossref | GoogleScholarGoogle Scholar |
Garner, D. L., and Seidel, G. E. (2008). History of commercializing sexed semen for cattle. Theriogenology 69, 886–895.
| History of commercializing sexed semen for cattle.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD1c3hsFertw%3D%3D&md5=32012a108078a786ed45dd0af8f385dfCAS |
Gordon, I. (2004). In vitro embryo production. In ‘Reproductive Technologies in Farm Animals’. (Eds G. J. Persley.) pp. 108–138. (CAB International.)
Hasler, J. F., McCauley, A. D., Lathrop, W. F., and Foote, R. H. (1987). Effect of donor–embryo–recipient interactions on pregnancy rate in a large-scale bovine embryo transfer program. Theriogenology 27, 139–168.
| Effect of donor–embryo–recipient interactions on pregnancy rate in a large-scale bovine embryo transfer program.Crossref | GoogleScholarGoogle Scholar |
Hussein, T. S., Thompson, J. G., and Gilchrist, R. B. (2006). Oocyte-secreted factors enhance oocyte developmental competence. Dev. Biol. 296, 514–521.
| Oocyte-secreted factors enhance oocyte developmental competence.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XotV2gsb4%3D&md5=02562f698c762d378021f5cb17dd2107CAS |
Ireland, J. J., Smith, G. W., Scheetz, D., Jimenez-Krassel, F., Folger, J. K., Ireland, J. L., Mossa, F., Lonergan, P., and Evans, A. C. (2011). Does size matter in females? An overview of the impact of the high variation in the ovarian reserve on ovarian function and fertility, utility of anti-Mullerian hormone as a diagnostic marker for fertility and causes of variation in the ovarian reserve in cattle. Reprod. Fertil. Dev. 23, 1–14.
| Does size matter in females? An overview of the impact of the high variation in the ovarian reserve on ovarian function and fertility, utility of anti-Mullerian hormone as a diagnostic marker for fertility and causes of variation in the ovarian reserve in cattle.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3M3ktFajtw%3D%3D&md5=56851b81e440214239dd103edde778f9CAS |
Labrecque, R., and Sirard, M. A. (2014). The study of mammalian oocyte competence by transcriptome analysis: progress and challenges. Mol. Hum. Reprod. 20, 103–116.
| The study of mammalian oocyte competence by transcriptome analysis: progress and challenges.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXhtVOnt70%3D&md5=398d943477169443368e85cac0cee14bCAS |
Lane, M., Mitchell, M., Cashman, K. S., Feil, D., Wakefield, S., and Zander-Fox, D. L. (2008). To QC or not to QC: the key to a consistent laboratory? Reprod. Fertil. Dev. 20, 23–32.
| To QC or not to QC: the key to a consistent laboratory?Crossref | GoogleScholarGoogle Scholar |
Lonergan, P. (2007). State-of-the-art embryo technologies in cattle. Soc. Reprod. Fertil. Suppl. 64, 315–325.
| 1:STN:280:DC%2BD2s3otlKiuw%3D%3D&md5=89cb25bf272038b15e2362353ba626b5CAS |
Merton, J. S., Vermeulen, Z. L., Otter, T., Mullaart, E., de Ruigh, L., and Hasler, J. F. (2007). Carbon-activated gas filtration during in vitro culture increased pregnancy rate following transfer of in vitro-produced bovine embryos. Theriogenology 67, 1233–1238.
| Carbon-activated gas filtration during in vitro culture increased pregnancy rate following transfer of in vitro-produced bovine embryos.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD2s7psFGnsA%3D%3D&md5=fce838ed1f39cc7854683946d94eb3c4CAS |
Morotti, F., Sanches, B. V., Pontes, J. H. F., Basso, A. C., Siqueira, E. R., Lisboa, L. A., and Seneda, M. M. (2014). Pregnancy rate and birth rate of calves from a large-scale IVF program using reverse-sorted semen in Bos indicus, Bos indicus–taurus, and Bos taurus cattle. Theriogenology 81, 696–701.
| Pregnancy rate and birth rate of calves from a large-scale IVF program using reverse-sorted semen in Bos indicus, Bos indicus–taurus, and Bos taurus cattle.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC2czksVKrsQ%3D%3D&md5=abf5bf331115c2398fa37e980676913eCAS |
Mossa, F., Walsh, S. W., Butler, S. T., Berry, D. P., Carter, F., Lonergan, P., Smith, G. W., Ireland, J. J., and Evans, A. C. (2012). Low numbers of ovarian follicles >/=3mm in diameter are associated with low fertility in dairy cows. J. Dairy Sci. 95, 2355–2361.
| Low numbers of ovarian follicles >/=3mm in diameter are associated with low fertility in dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XlvFygtLo%3D&md5=8bc24b57cd5e58c40b5690ee2fead297CAS |
Moussa, M., Shu, J., Zhang, X. H., and Zeng, F. (2015). Maternal control of oocyte quality in cattle. Anim. Reprod. Sci. 155, 11–27.
| Maternal control of oocyte quality in cattle.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC2MrpslGgtw%3D%3D&md5=49b6b94783276bab4bb46551cbc0bf2fCAS |
Nature Special Edition (2010). Can science feed the world? Nature 466, 531–660.
Perry, G. (2015). 2013 Statistics of embryo collection and transfer in domestic farm animals. Embryo Transfer Newsletter 33, 14–26.
Pontes, J. H. F., Silva, K. C. F., Basso, A. C., Rigo, A. G., Ferreira, C. R., Santos, G. M. G., Sanches, B. V., Porcionato, J. P. F., Vieira, P. H. S., Faifer, F. S., Sterza, F. A. M., Schenk, J. L., and Seneda, M. M. (2010). Large-scale in vitro embryo production and pregnancy rates from Bos taurus, Bos indicus, and indicus–taurus dairy cows using sexed sperm. Theriogenology 74, 1349–1355.
| Large-scale in vitro embryo production and pregnancy rates from Bos taurus, Bos indicus, and indicus–taurus dairy cows using sexed sperm.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3cfntlyqsA%3D%3D&md5=64a9e42ff9e822e4c132b81d93518b34CAS |
Shojaei Saadi, H. A., Vigneault, C., Sargolzaei, M., Gagné, D., Fournier, E., de Montera, B., Chesnais, J., Blondin, P., and Robert, C. (2014). Impact of whole-genome amplification on the reliability of pre-transfer cattle embryo breeding value estimates. BMC Genomics 15, 889.
| Impact of whole-genome amplification on the reliability of pre-transfer cattle embryo breeding value estimates.Crossref | GoogleScholarGoogle Scholar |
Sinclair, K. D., McEvoy, T. G., Maxfield, E. K., Maltin, C. A., Young, L. E., Wilmut, I., Broadbent, P. J., and Robinson, J. J. (1999). Aberrant fetal growth and development after in vitro culture of sheep zygotes. J. Reprod. Fertil. 116, 177–186.
| Aberrant fetal growth and development after in vitro culture of sheep zygotes.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1MXjvVemtr4%3D&md5=88e01b23b0fc2cfc055bc1d3207e39adCAS |
Sirard, M. A., Richard, F., Blondin, P., and Robert, C. (2006). Contribution of the oocyte to embryo quality. Theriogenology 65, 126–136.
| Contribution of the oocyte to embryo quality.Crossref | GoogleScholarGoogle Scholar |
Ward, F. A., Lonergan, P., Enright, B. P., and Boland, M. P. (2000). Factors affecting recovery and quality of oocytes for bovine embryo production in vitro using ovum pick-up technology. Theriogenology 54, 433–446.
| Factors affecting recovery and quality of oocytes for bovine embryo production in vitro using ovum pick-up technology.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3crgt1yrsQ%3D%3D&md5=e9b11f2e9e5c3cff7cf46dec89a076b1CAS |
Zander, D. L., Thompson, J. G., and Lane, M. (2006). Perturbations in mouse embryo development and viability caused by ammonium are more severe after exposure at the cleavage stages. Biol. Reprod. 74, 288–294.
| Perturbations in mouse embryo development and viability caused by ammonium are more severe after exposure at the cleavage stages.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28Xot1KlsA%3D%3D&md5=c0554992e191cec3452d0143f263471dCAS |
