Optineurin suppression activates the mediators involved in the terminal effector pathways of human labour and delivery
Ratana Lim A B , Gillian Barker A B and Martha Lappas A B C
+ Author Affiliations
- Author Affiliations
A Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, The University of Melbourne, Vic. 3084, Australia.
B Mercy Perinatal Research Centre, Mercy Hospital for Women, 4th Floor, 163 Studley Rd, Heidelberg, Vic. 3084, Australia.
C Corresponding author. Email: mlappas@unimelb.edu.au
Reproduction, Fertility and Development 29(6) 1074-1084 https://doi.org/10.1071/RD15494
Submitted: 25 November 2015 Accepted: 19 February 2016 Published: 2 May 2016
Abstract
Spontaneous preterm birth remains the major cause of neonatal death and morbidity. Studies in non-gestational tissues report that optineurin (OPTN) is critical in the termination of NFKB1 activity and control of inflammation, central features of spontaneous preterm birth. The aims of the present study were to determine: (1) OPTN expression in fetal membranes and the myometrium during labour; (2) the effects of IL1B on OPTN expression in primary myometrial cells; and (3) the effects of OPTN short interference (si) RNA on IL1B-stimulated proinflammatory and prolabour mediators. OPTN mRNA and protein expression was significantly decreased with spontaneous term labour in fetal membranes and the myometrium. Although there was no effect of spontaneous preterm labour on OPTN expression in fetal membranes, there was decreased OPTN expression in membranes with chorioamnionitis and myometrial cells treated with 1ng mL–1 IL1B for 1 or 6 h. In cells transfected with OPTN siRNA, significant increases were seen in IL1B-stimulated IL6, tumour necrosis factor, CXCL8 and monocyte chemoattractant protein-1 mRNA expression and release, cyclo-oxygenase-2 and prostanoid PTGFR receptor mRNA expression and the release of prostaglandin F2α. There was no change in IL1B-stimulated NFKBIA expression; however, there was increased NFKB1 p65 DNA-binding activity. The results of the present study suggest that OPTN is a negative regulator of inflammation-induced prolabour mediators.
Additional keywords: infection, inflammation, myometrium, preterm birth.
References
Akizuki, M., Yamashita, H., Uemura, K., Maruyama, H., Kawakami, H., Ito, H., and Takahashi, R. (2013). Optineurin suppression causes neuronal cell death via NF-kappaB pathway. J. Neurochem. 126, 699–704.| Optineurin suppression causes neuronal cell death via NF-kappaB pathway.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXhtl2lt7zI&md5=79aa7833333dd2965afa67fa550a5e53CAS | 23721573PubMed |
Albagha, O. M. E., Visconti, M. R., Alonso, N., Langston, A. L., Cundy, T., Dargie, R., Dunlop, M. G., Fraser, W. D., Hooper, M. J., Isaia, G., Nicholson, G. C., Montes, J. D., Gonzalez-Sarmiento, R., di Stefano, M., Tenesa, A., Walsh, J. P., and Ralston, S. H. (2010). Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget’s disease of bone. Nat. Genet. 42, 520–524.
| Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget’s disease of bone.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXlsVyitbg%3D&md5=71ed13f0ec01ec7bec3f914377fc1491CAS |
Baergen, R., Benirschke, K., and Ulich, T. R. (1994). Cytokine expression in the placenta. The role of interleukin 1 and interleukin 1 receptor antagonist expression in chorioamnionitis and parturition. Arch. Pathol. Lab. Med. 118, 52–55.
| 1:STN:280:DyaK2c7htlyrtA%3D%3D&md5=30ca702bf5e0a9e35414216c834971d2CAS | 7506905PubMed |
March of Dimes, PMNCH, Save the Children, WHO (2013). ‘Born Too Soon: The Global Action Report on Preterm Birth.’ (Eds CP Howson, MV Kinney, JE Lawn) (World Health Organization: Geneva)
Brodt-Eppley, J., and Myatt, L. (1999). Prostaglandin receptors in lower segment myometrium during gestation and labor. Obstet. Gynecol. 93, 89–93.
| Prostaglandin receptors in lower segment myometrium during gestation and labor.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1MXmsVamsg%3D%3D&md5=4efea60bd3463ff9cfd43a7204c9c5a5CAS | 9916963PubMed |
Buhimschi, C. S., Schatz, F., Krikun, G., Buhimschi, I. A., and Lockwood, C. J. (2010). Novel insights into molecular mechanisms of abruption-induced preterm birth. Expert Rev. Mol. Med. 12, e35.
| Novel insights into molecular mechanisms of abruption-induced preterm birth.Crossref | GoogleScholarGoogle Scholar | 21040617PubMed |
Chalasani, M. L., Swarup, G., and Balasubramanian, D. (2009). Optineurin and its mutants: molecules associated with some forms of glaucoma. Ophthalmic Res. 42, 176–184.
| Optineurin and its mutants: molecules associated with some forms of glaucoma.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhsFWrsrzM&md5=e6fb96328cd09f1f8aff9efbe83bb7efCAS | 19672125PubMed |
Chan, Y. W., van den Berg, H. A., Moore, J. D., Quenby, S., and Blanks, A. M. (2014). Assessment of myometrial transcriptome changes associated with spontaneous human labour by high-throughput RNA-seq. Exp. Physiol. 99, 510–524.
| Assessment of myometrial transcriptome changes associated with spontaneous human labour by high-throughput RNA-seq.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXjvVyhsLY%3D&md5=2ab5a4cadc036f0b95917fceac93f064CAS | 24273302PubMed |
Chevillard, G., Derjuga, A., Devost, D., Zingg, H. H., and Blank, V. (2007). Identification of interleukin-1beta regulated genes in uterine smooth muscle cells. Reproduction 134, 811–822.
| Identification of interleukin-1beta regulated genes in uterine smooth muscle cells.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXmt1ehug%3D%3D&md5=a85cf00a29c876587e93e87ea319dd3cCAS | 18042638PubMed |
Chew, T. S., O’Shea, N. R., Sewell, G. W., Oehlers, S. H., Mulvey, C. M., Crosier, P. S., Godovac-Zimmermann, J., Bloom, S. L., Smith, A. M., and Segal, A. W. (2015). Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis. Dis. Model. Mech. 8, 817–829.
| Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis.Crossref | GoogleScholarGoogle Scholar | 26044960PubMed |
Christiaens, I., Zaragoza, D. B., Guilbert, L., Robertson, S. A., Mitchell, B. F., and Olson, D. M. (2008). Inflammatory processes in preterm and term parturition. J. Reprod. Immunol. 79, 50–57.
| Inflammatory processes in preterm and term parturition.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXht1eju7rE&md5=5098797a3ccbaf11b6862b80ebd83e71CAS | 18550178PubMed |
Cogswell, J. P., Godlevski, M. M., Wisely, G. B., Clay, W. C., Leesnitzer, L. M., Ways, J. P., and Gray, J. G. (1994). NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site. J. Immunol. 153, 712–723.
| 1:CAS:528:DyaK2MXjtVOhtg%3D%3D&md5=0be5a8413472ef336949d1f7acab57cdCAS | 8021507PubMed |
Døllner, H., Vatten, L., Halgunset, J., Rahimipoor, S., and Austgulen, R. (2002). Histologic chorioamnionitis and umbilical serum levels of pro-inflammatory cytokines and cytokine inhibitors. BJOG 109, 534–539.
| Histologic chorioamnionitis and umbilical serum levels of pro-inflammatory cytokines and cytokine inhibitors.Crossref | GoogleScholarGoogle Scholar | 12066943PubMed |
Esplin, M. S., Peltier, M. R., Hamblin, S., Smith, S., Fausett, M. B., Dildy, G. A., Branch, D. W., Silver, R. M., and Adashi, E. Y. (2005). Monocyte chemotactic protein-1 expression is increased in human gestational tissues during term and preterm labor. Placenta 26, 661–671.
| Monocyte chemotactic protein-1 expression is increased in human gestational tissues during term and preterm labor.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXns1Wgsb0%3D&md5=e468ee7eae385786333ba41d19c51afbCAS | 16085045PubMed |
Flores-Herrera, H., Garcia-Lopez, G., Diaz, N. F., Molina-Hernandez, A., Osorio-Caballero, M., Soriano-Becerril, D., and Zaga-Clavellina, V. (2012). An experimental mixed bacterial infection induced differential secretion of proinflammatory cytokines (IL-1beta, TNFalpha) and proMMP-9 in human fetal membranes. Placenta 33, 271–277.
| An experimental mixed bacterial infection induced differential secretion of proinflammatory cytokines (IL-1beta, TNFalpha) and proMMP-9 in human fetal membranes.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XivV2hsrw%3D&md5=c3ef6ea1263ca88fc0105f7a0621ab4aCAS | 22280559PubMed |
Fortier, M. A., Krishnaswamy, K., Danyod, G., Boucher-Kovalik, S., and Chapdalaine, P. (2008). A postgenomic integrated view of prostaglandins in reproduction: implications for other body systems. J. Physiol. Pharmacol. 59, 65–89.
| 18802217PubMed |
Goldenberg, R. L., Culhane, J. F., Iams, J. D., and Romero, R. (2008). Epidemiology and causes of preterm birth. Lancet 371, 75–84.
| Epidemiology and causes of preterm birth.Crossref | GoogleScholarGoogle Scholar | 18177778PubMed |
Holdsworth-Carson, S. J., Permezel, M., Rice, G. E., and Lappas, M. (2009). Preterm and infection-driven preterm labor: the role of peroxisome proliferator-activated receptors and retinoid X receptor. Reproduction 137, 1007–1015.
| Preterm and infection-driven preterm labor: the role of peroxisome proliferator-activated receptors and retinoid X receptor.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXovVKgtrs%3D&md5=f3a2fb3901e8407e50dd7ab9ba5e76a0CAS | 19279199PubMed |
Houben, M. L., Nikkels, P. G., van Bleek, G. M., Visser, G. H., Rovers, M. M., Kessel, H., de Waal, W. J., Schuijff, L., Evers, A., Kimpen, J. L., and Bont, L. (2009). The association between intrauterine inflammation and spontaneous vaginal delivery at term: a cross-sectional study. PLoS One 4, e6572.
| The association between intrauterine inflammation and spontaneous vaginal delivery at term: a cross-sectional study.Crossref | GoogleScholarGoogle Scholar | 19668329PubMed |
Kim, C. J., Romero, R., Chaemsaithong, P., Chaiyasit, N., Yoon, B. H., and Kim, Y. M. (2015). Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance. Am. J. Obstet. Gynecol. 213, S29–S52.
| Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance.Crossref | GoogleScholarGoogle Scholar | 26428501PubMed |
Lappas, M. (2015). KLF5 regulates infection- and inflammation-induced pro-labour mediators in human myometrium. Reproduction 149, 413–424.
| KLF5 regulates infection- and inflammation-induced pro-labour mediators in human myometrium.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2MXhtVCkurvO&md5=9a05c8d9984250335f7062408b9f5f7eCAS | 25687411PubMed |
Lappas, M., and Rice, G. E. (2007). The role and regulation of the nuclear factor kappa B signalling pathway in human labour. Placenta 28, 543–556.
| The role and regulation of the nuclear factor kappa B signalling pathway in human labour.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXksV2mtrk%3D&md5=6681cb84c2f1a62aa5fdfb214c0dafebCAS | 16843526PubMed |
Lappas, M., and Rice, G.E. (2009). Transcriptional regulation of the processes of human labour and delivery. Placenta 30, S90–S95.
| Transcriptional regulation of the processes of human labour and delivery.Crossref | GoogleScholarGoogle Scholar | 19010537PubMed |
Lappas, M., Mitton, A., Lim, R., Barker, G., Riley, C., and Permezel, M. (2011). SIRT1 is a novel regulator of key pathways of human labor. Biol. Reprod. 84, 167–178.
| SIRT1 is a novel regulator of key pathways of human labor.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXlvVegu78%3D&md5=f419b44dd8ccb86ed0073988c11cc63cCAS | 20844277PubMed |
Lim, R., and Lappas, M. (2014). Differential expression of AP-1 proteins in human myometrium after spontaneous term labour onset. Eur. J. Obstet. Gynecol. Reprod. Biol. 177, 100–105.
| Differential expression of AP-1 proteins in human myometrium after spontaneous term labour onset.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXnt1egs7s%3D&md5=9fc7fd58d2cf522e0fb95e7b217afc89CAS | 24784710PubMed |
Lim, R., Barker, G., and Lappas, M. (2014). TREM-1 expression is increased in human placentas from severe early-onset preeclamptic pregnancies where it may be involved in syncytialization. Reprod. Sci. 21, 562–572.
| TREM-1 expression is increased in human placentas from severe early-onset preeclamptic pregnancies where it may be involved in syncytialization.Crossref | GoogleScholarGoogle Scholar | 24026310PubMed |
Lindström, T. M., and Bennett, P. R. (2005). The role of nuclear factor kappa B in human labour. Reproduction 130, 569–581.
| The role of nuclear factor kappa B in human labour.Crossref | GoogleScholarGoogle Scholar | 16264088PubMed |
Liong, S., and Lappas, M. (2014). Endoplasmic reticulum stress is increased after spontaneous labor in human fetal membranes and myometrium where it regulates the expression of prolabor mediators. Biol. Reprod. 91, 70.
| Endoplasmic reticulum stress is increased after spontaneous labor in human fetal membranes and myometrium where it regulates the expression of prolabor mediators.Crossref | GoogleScholarGoogle Scholar | 25100709PubMed |
Liu, L., Johnson, H. L., Cousens, S., Perin, J., Scott, S., Lawn, J. E., Rudan, I., Campbell, H., Cibulskis, R., Li, M., Mathers, C., Black, R. E., for the Child Health Epidemiology Reference Group of WHO and UNICEF (2012). Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet 379, 2151–2161.
| Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000.Crossref | GoogleScholarGoogle Scholar | 22579125PubMed |
Maruyama, H., Morino, H., Ito, H., Izumi, Y., Kato, H., Watanabe, Y., Kinoshita, Y., Kamada, M., Nodera, H., Suzuki, H., Komure, O., Matsuura, S., Kobatake, K., Morimoto, N., Abe, K., Suzuki, N., Aoki, M., Kawata, A., Hirai, T., Kato, T., Ogasawara, K., Hirano, A., Takumi, T., Kusaka, H., Hagiwara, K., Kaji, R., and Kawakami, H. (2010). Mutations of OPTN in amyotrophic lateral sclerosis. Nature 465, 223–226.
| Mutations of OPTN in amyotrophic lateral sclerosis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXltlWmtr8%3D&md5=29eebe53fa947881917046f8c0c210c6CAS | 20428114PubMed |
Molnár, M., Romero, R., and Hertelendy, F. (1993). Interleukin-1 and tumor necrosis factor stimulate arachidonic acid release and phospholipid metabolism in human myometrial cells. Am. J. Obstet. Gynecol. 169, 825–829.
| Interleukin-1 and tumor necrosis factor stimulate arachidonic acid release and phospholipid metabolism in human myometrial cells.Crossref | GoogleScholarGoogle Scholar | 8238136PubMed |
Mosher, A. A., Rainey, K. J., Bolstad, S. S., Lye, S. J., Mitchell, B. F., Olson, D. M., Wood, S. L., and Slater, D. M. (2013). Development and validation of primary human myometrial cell culture models to study pregnancy and labour. BMC Pregnancy Childbirth 13, S1–S7.
| Development and validation of primary human myometrial cell culture models to study pregnancy and labour.Crossref | GoogleScholarGoogle Scholar |
Nagabhushana, A., Chalasani, M. L., Jain, N., Radha, V., Rangaraj, N., Balasubramanian, D., and Swarup, G. (2010). Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant. BMC Cell Biol. 11, 4.
| Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant.Crossref | GoogleScholarGoogle Scholar | 20085643PubMed |
Nagabhushana, A., Bansal, M., and Swarup, G. (2011). Optineurin is required for CYLD-dependent inhibition of TNFalpha-induced NF-kappaB activation. PLoS One 6, e17477.
| Optineurin is required for CYLD-dependent inhibition of TNFalpha-induced NF-kappaB activation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXjsFShs7Y%3D&md5=850547101e31f3e39a43d383a5420900CAS | 21408173PubMed |
O’Brien, W. F. (1995). The role of prostaglandins in labor and delivery. Clin. Perinatol. 22, 973–984.
| 1:STN:280:DyaK283it1Gltg%3D%3D&md5=f861b4dde024a7aeb83ee617166e4fb6CAS | 8665768PubMed |
Olson, D. M., Zaragoza, D. B., Shallow, M. C., Cook, J. L., Mitchell, B. F., Grigsby, P., and Hirst, J. (2003). Myometrial activation and preterm labour: evidence supporting a role for the prostaglandin F receptor. A review. Placenta 24, S47–S54.
| Myometrial activation and preterm labour: evidence supporting a role for the prostaglandin F receptor. A review.Crossref | GoogleScholarGoogle Scholar | 12842413PubMed |
Osman, I., Young, A., Ledingham, M. A., Thomson, A. J., Jordan, F., Greer, I. A., and Norman, J. E. (2003). Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term. Mol. Hum. Reprod. 9, 41–45.
| Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXislSkt74%3D&md5=652f164921e70a7d5010ad0479c01a8cCAS | 12529419PubMed |
Petrou, S., Eddama, O., and Mangham, L. (2011). A structured review of the recent literature on the economic consequences of preterm birth. Arch. Dis. Child. Fetal Neonatal Ed. 96, F225–F232.
| A structured review of the recent literature on the economic consequences of preterm birth.Crossref | GoogleScholarGoogle Scholar | 20488863PubMed |
Romero, R., Espinoza, J., Goncalves, L. F., Kusanovic, J. P., Friel, L. A., and Nien, J. K. (2006a). Inflammation in preterm and term labour and delivery. Semin. Fetal Neonatal Med. 11, 317–326.
| Inflammation in preterm and term labour and delivery.Crossref | GoogleScholarGoogle Scholar | 16839830PubMed |
Romero, R., Espinoza, J., Goncalves, L. F., Kusanovic, J. P., Friel, L. A., and Nien, J. K. (2006b). Inflammation in preterm and term labour and delivery. Semin. Fetal Neonatal Med. 11, 317–326.
| Inflammation in preterm and term labour and delivery.Crossref | GoogleScholarGoogle Scholar | 16839830PubMed |
Romero, R., Espinoza, J., Goncalves, L. F., Kusanovic, J. P., Friel, L., and Hassan, S. (2007). The role of inflammation and infection in preterm birth. Semin. Reprod. Med. 25, 21–39.
| The role of inflammation and infection in preterm birth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhvFynur0%3D&md5=ae7f5c4cd9508d31114f0b08389ba5bcCAS | 17205421PubMed |
Romero, R., Chaiworapongsa, T., Alpay Savasan, Z., Xu, Y., Hussein, Y., Dong, Z., Kusanovic, J. P., Kim, C. J., and Hassan, S. S. (2011). Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1. J. Matern. Fetal Neonatal Med. 24, 1444–1455.
| Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhsVGrt7%2FM&md5=d5b17d10f3b77cd906300299011e24f6CAS | 21958433PubMed |
Romero, R., Miranda, J., Chaiworapongsa, T., Korzeniewski, S. J., Chaemsaithong, P., Gotsch, F., Dong, Z., Ahmed, A. I., Yoon, B. H., Hassan, S. S., Kim, C. J., and Yeo, L. (2014). Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes. Am. J. Reprod. Immunol. 72, 458–474.
| Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXhslSrs73O&md5=12b3414beff88f10209ecacaef5a3d6fCAS | 25078709PubMed |
Saccani, S., Marazzi, I., Beg, A. A., and Natoli, G. (2004). Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response. J. Exp. Med. 200, 107–113.
| Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXlslWmsrk%3D&md5=eca1c47a58daf0138aff564775174133CAS | 15226358PubMed |
Sadowsky, D. W., Adams, K. M., Gravett, M. G., Witkin, S. S., and Novy, M. J. (2006). Preterm labor is induced by intraamniotic infusions of interleukin-1beta and tumor necrosis factor-alpha but not by interleukin-6 or interleukin-8 in a nonhuman primate model. Am. J. Obstet. Gynecol. 195, 1578–1589.
| Preterm labor is induced by intraamniotic infusions of interleukin-1beta and tumor necrosis factor-alpha but not by interleukin-6 or interleukin-8 in a nonhuman primate model.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28Xht1eksr7E&md5=e081360b934bcbf65cf7c84c99ac40adCAS | 17132473PubMed |
Saigal, S., and Doyle, L. W. (2008). An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet 371, 261–269.
| An overview of mortality and sequelae of preterm birth from infancy to adulthood.Crossref | GoogleScholarGoogle Scholar | 18207020PubMed |
Salafia, C. M., Weigl, C., and Silberman, L. (1989). The prevalence and distribution of acute placental inflammation in uncomplicated term pregnancies. Obstet. Gynecol. 73, 383–389.
| 1:STN:280:DyaL1M7ivVSitw%3D%3D&md5=8fafcb5e3722f1d6d9fbf00a371cf5f8CAS | 2915862PubMed |
Schwamborn, K., Weil, R., Courtois, G., Whiteside, S. T., and Israel, A. (2000). Phorbol esters and cytokines regulate the expression of the NEMO-related protein, a molecule involved in a NF-kappa B-independent pathway. J. Biol. Chem. 275, 22780–22789.
| Phorbol esters and cytokines regulate the expression of the NEMO-related protein, a molecule involved in a NF-kappa B-independent pathway.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXltlGru78%3D&md5=2f1665be08a62e6c43e0424e7075131bCAS | 10807909PubMed |
Shynlova, O., Tsui, P., Dorogin, A., and Lye, S. J. (2008). Monocyte chemoattractant protein-1 (CCL-2) integrates mechanical and endocrine signals that mediate term and preterm labor. J. Immunol. 181, 1470–1479.
| Monocyte chemoattractant protein-1 (CCL-2) integrates mechanical and endocrine signals that mediate term and preterm labor.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXotF2rtLw%3D&md5=71f7b8ad1c223ce69a16229f9156d842CAS | 18606702PubMed |
Smith, A. M., Sewell, G. W., Levine, A. P., Chew, T. S., Dunne, J., O’Shea, N. R., Smith, P. J., Harrison, P. J., Macdonald, C. M., Bloom, S. L., and Segal, A. W. (2015). Disruption of macrophage pro-inflammatory cytokine release in Crohn’s disease is associated with reduced optineurin expression in a subset of patients. Immunology 144, 45–55.
| Disruption of macrophage pro-inflammatory cytokine release in Crohn’s disease is associated with reduced optineurin expression in a subset of patients.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXitVegurvO&md5=7996a8ba43afa01022e5d219df714bc9CAS | 24943399PubMed |
Sudhakar, C., Nagabhushana, A., Jain, N., and Swarup, G. (2009). NF-kappaB mediates tumor necrosis factor alpha-induced expression of OPTN, a negative regulator of NF-kappaB. PLoS One 4, e5114.
| NF-kappaB mediates tumor necrosis factor alpha-induced expression of OPTN, a negative regulator of NF-kappaB.Crossref | GoogleScholarGoogle Scholar | 19340308PubMed |
Tita, A. T., and Andrews, W. W. (2010). Diagnosis and management of clinical chorioamnionitis. Clin. Perinatol. 37, 339–354.
| Diagnosis and management of clinical chorioamnionitis.Crossref | GoogleScholarGoogle Scholar | 20569811PubMed |
Tribe, R. M., Moriarty, P., Dalrymple, A., Hassoni, A. A., and Poston, L. (2003). Interleukin-1beta induces calcium transients and enhances basal and store operated calcium entry in human myometrial smooth muscle. Biol. Reprod. 68, 1842–1849.
| Interleukin-1beta induces calcium transients and enhances basal and store operated calcium entry in human myometrial smooth muscle.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXjt12ltLc%3D&md5=da8b7e24bdfb9ed6e91b4e60fb9e2b39CAS | 12606352PubMed |
Uchide, N., Ohyama, K., Bessho, T., Takeichi, M., and Toyoda, H. (2012). Possible roles of proinflammatory and chemoattractive cytokines produced by human fetal membrane cells in the pathology of adverse pregnancy outcomes associated with influenza virus infection. Mediators Inflamm. 2012, Article ID 270670.
| Possible roles of proinflammatory and chemoattractive cytokines produced by human fetal membrane cells in the pathology of adverse pregnancy outcomes associated with influenza virus infection.Crossref | GoogleScholarGoogle Scholar |
Vittitow, J., and Borras, T. (2002). Expression of optineurin, a glaucoma-linked gene, is influenced by elevated intraocular pressure. Biochem. Biophys. Res. Commun. 298, 67–74.
| Expression of optineurin, a glaucoma-linked gene, is influenced by elevated intraocular pressure.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38Xns1Gmtb4%3D&md5=c3b3b1db5e5ab9256a978b35638ccc3cCAS | 12379221PubMed |
Ying, H., and Yue, B. Y. (2012). Cellular and molecular biology of optineurin. Int. Rev. Cell Mol. Biol. 294, 223–258.
| Cellular and molecular biology of optineurin.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhsFKgsLrP&md5=bec8fe3482eb4129687514ca6a99edbdCAS | 22364875PubMed |
Zhu, G., Wu, C. J., Zhao, Y., and Ashwell, J. D. (2007). Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP. Curr. Biol. 17, 1438–1443.
| Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXpt1Kns74%3D&md5=e15450fecca2ac50c117519f0efb806bCAS | 17702576PubMed |
