Thyroid function and autoimmunity during ovarian stimulation for intracytoplasmic sperm injection
Gesthimani Mintziori A , Dimitrios G. Goulis A C , Efstratios M. Kolibianakis A , Aristidis Slavakis B , Julia Bosdou A , Grigorios Grimbizis A and Basil C. Tarlatzis A
+ Author Affiliations
- Author Affiliations
A Unit of Reproductive Endocrinology and Unit of Human Reproduction, First Department of Obstetrics and Gynecology, School of Medicine, Aristotle University of Thessaloniki, Greece.
B Department of Biochemistry, Hormone Assay Laboratory, Hippokration Hospital, Thessaloniki, Greece.
C Corresponding author. Email: dimitrios.goulis@otenet.gr
Reproduction, Fertility and Development 29(3) 603-608 https://doi.org/10.1071/RD15172
Submitted: 3 May 2015 Accepted: 31 August 2015 Published: 8 October 2015
Abstract
The aim of the present study was to assess changes in thyroid function and thyroid autoimmunity (TAI) throughout ovarian stimulation (OS) for intracytoplasmic sperm injection (ICSI) and the association of these changes with ICSI outcome. A flexible gonadotrophin-releasing hormone (GnRH) antagonist protocol was used in 42 women and their thyroid function and TAI were assessed at baseline and five times during OS (Days 3 and 5 of the menstrual cycle, the day of hCG administration, the day of ovum pick-up and the day of the pregnancy test). The primary outcome measure was the change in thyroid function throughout OS. No overall change was recorded in thyrotropin-stimulating hormone (TSH) concentrations throughout OS (P = 0.066). In women who became pregnant (n = 8), an increase in TSH concentrations was noted on the day of the pregnancy test compared with Day 3 of the menstrual cycle (3.410 ± 1.200 vs 2.014 ± 0.950 μIU mL–1, respectively; P = 0.001; mean ± s.d.). TAI was present in 11 of 42 women. Biochemical pregnancy was negatively correlated with changes in TSH (r = –0.7, P = 0.004). No such association was noted regarding the live birth rate. The present study provides evidence that TSH concentrations could increase during OS, especially in women who become pregnant.
Additional keywords: assisted reproduction, ovary.
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