Why we should not select the faster embryo: lessons from mice and cattle
Alfonso Gutierrez-Adan A , Carlee R. White C D E , Ann Van Soom B and Mellissa R. W. Mann C D E F
+ Author Affiliations
- Author Affiliations
A Departamento de Reproducción Animal y Conservación de Recursos Zoogenéticos, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Ctra de la Coruña Km 5,9 28040 Madrid Spain.
B Department of Reproduction, Obstetrics and Herd Health, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
C Department of Obstetrics and Gynecology, University of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada.
D Department of Biochemistry, University of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada.
E Children’s Health Research Institute, 800 Commissioners Rd E, London, Ontario, N6C 2V5, Canada.
F Corresponding author. Email: mmann22@uwo.ca
Reproduction, Fertility and Development 27(5) 765-775 https://doi.org/10.1071/RD14216
Submitted: 18 June 2014 Accepted: 5 August 2014 Published: 11 September 2014
Abstract
Many studies have shown that in vitro culture can negatively impact preimplantation development. This necessitates some selection criteria for identifying the best-suited embryos for transfer. That said, embryo selection after in vitro culture remains a subjective process in most mammalian species, including cows, mice and humans. General consensus in the field is that embryos that develop in a timely manner have the highest developmental competence and viability after transfer. Herein lies the key question: what is a timely manner? With emerging data in bovine and mouse supporting increased developmental competency in embryos with moderate rates of development, it is time to question whether the fastest developing embryos are the best embryos for transfer in the human clinic. This is especially relevant to epigenetic gene regulation, including genomic imprinting, where faster developing embryos exhibit loss of imprinted methylation, as well as to sex selection bias, where faster developmental rates of male embryos may lead to biased embryo transfer and, in turn, biased sex ratios. In this review, we explore evidence surrounding the question of developmental timing as it relates to bovine embryo quality, mouse embryo quality and genomic imprint maintenance, and embryo sex.
Additional keywords: developmental kinetics, embryo culture, embryo quality, epigenetics, sex.
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