Endothelin as a local regulating factor in the bovine oviduct
Yuki Yamamoto A , Misa Kohka A , Yoshihiko Kobayashi A , Izabela Woclawek-Potocka B and Kiyoshi Okuda A C
+ Author Affiliations
- Author Affiliations
A Laboratory of Reproductive Physiology, Graduate School of Environmental and Life Science, Okayama University, 1-1-1 Tsushimanaka, Kita-ku, Okayama, Okayama, 700-8530, Japan.
B Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10–747 Olsztyn, Poland.
C Corresponding author. Email: kokuda@okayama-u.ac.jp
Reproduction, Fertility and Development 28(6) 673-681 https://doi.org/10.1071/RD14076
Submitted: 24 February 2014 Accepted: 8 September 2014 Published: 5 November 2014
Abstract
Endothelin (EDN) is a possible regulating factor of oviductal motility, which is important for the transport of gametes and embryo. To clarify the factors that control the secretion of EDN in the bovine oviduct, the expression of EDNs, EDN-converting enzymes (ECEs) and EDN receptors (EDNRs) were investigated. All isoforms of EDN (EDN1–3), ECE (ECE1 and ECE2) and EDNR (EDNRA and EDNRB) were immunolocalised in the epithelial cells of the ampulla and the isthmus. EDNRs were also immunolocalised in smooth-muscle cells. The mRNA expression of EDN2 and ECE2 was higher in cultured ampullary oviductal epithelial cells than in isthmic cells. The expression of EDN1, EDN2 and ECE2 in the ampullary tissue was highest on the day of ovulation. Oestradiol-17β increased EDN2 and ECE1 expression, while progesterone increased only ECE1 expression in cultured ampullary epithelial cells. These results indicate that EDNs are produced by epithelial cells and their target site is smooth-muscle and epithelial cells, and suggest that ovarian steroids are regulators of endothelin synthesis in ampullary oviductal epithelial cells.
Additional keywords: endothelin converting enzyme, endothelin receptor, epithelial cell, ovarian steroids, oviductal contraction and relaxation.
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