Altered pregnancy outcomes in mice following treatment with the hyperglycaemia mimetic, glucosamine, during the periconception period
Cheryl J. Schelbach A , Rebecca L. Robker A , Brenton D. Bennett A , Ashley D. Gauld A , Jeremy G. Thompson A and Karen L. Kind B C
+ Author Affiliations
- Author Affiliations
A The Robinson Institute, The Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide, SA 5005, Australia.
B The Robinson Institute, The Research Centre for Reproductive Health, School of Animal and Veterinary Sciences, The University of Adelaide, Adelaide, SA 5005, Australia.
C Corresponding author. Email: karen.kind@adelaide.edu.au
Reproduction, Fertility and Development 25(2) 405-416 https://doi.org/10.1071/RD11313
Submitted: 16 December 2011 Accepted: 31 March 2012 Published: 21 May 2012
Abstract
Exposure of cumulus–oocyte complexes to the hyperglycaemia mimetic, glucosamine, during in vitro maturation impairs embryo development, potentially through upregulation of the hexosamine biosynthesis pathway. This study examined the effects of in vivo periconception glucosamine exposure on reproductive outcomes in young healthy mice, and further assessed the effects in overweight mice fed a high-fat diet. Eight-week-old mice received daily glucosamine injections (20 or 400 mg kg–1) for 3–6 days before and 1 day after mating (periconception). Outcomes were assessed at Day 18 of gestation. Glucosamine treatment reduced litter size independent of dose. A high-fat diet (21% fat) for 11 weeks before and during pregnancy reduced fetal size. No additional effects of periconception glucosamine (20 mg kg–1) on pregnancy outcomes were observed in fat-fed mice. In 16-week-old mice fed the control diet, glucosamine treatment reduced fetal weight and increased congenital abnormalities, but did not alter litter size. As differing effects of glucosamine were observed in 8-week-old and 16-week-old mice, maternal age effects were assessed. Periconception glucosamine at 8 weeks reduced litter size, whereas glucosamine at 16 weeks reduced fetal size. Thus, in vivo periconception glucosamine exposure perturbs reproductive outcomes in mice, with the nature of the outcomes dependent upon maternal age.
Additional keywords: fetal development, hexosamine biosynthesis pathway.
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