Testicular torsion is the condition whereby the testis is twisted about the spermatic cord, thus, cutting off blood supply to the testis. It is a painful condition that often leads to infertility. Therefore, in this study, we determined the protective effect of pentoxifylline against testicular damage in the condition of testicular torsion and subsequent detorsion in mouse model. The result of this study showed that pentoxifylline aids the survival of germ cells and prevent testicular apoptosis.

Ovarian quiescence in women and in animals can be due to hormonal deficiency caused by apoptosis of granulosa cells responsible for hormone synthesis. In an alternative to the classical approach with hormonal treatment, regenerative medicine by platelet rich plasma could be a new treatment available. In this study, an in vitro model represented by ovarian slices and granulosa cells treated by platelet rich plasma stimulated granulosa cell proliferation and increased hormone levels. This treatment could improve the reproductive ability of quiescent females. (a) Green apoptotic granulosa cells with membrane budding and red dead granulose cell. (b) Live granulosa cells with defined margins after platelet rich plasma treatment.